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Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Epristeride's metabolism involves key metabolites and proteins, affecting its use in doping tests.

Baricitinib works better than methotrexate for severe alopecia areata.

Disitamab vedotin and gemcitabine effectively treated bladder cancer without major side effects.

The combination treatment showed a higher response rate but no significant survival benefits.

The combination of high-dose toremifene and capecitabine was effective for advanced recurrent breast cancer.

PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.

N-acetylcysteine was more effective and had fewer side effects than metformin for improving insulin resistance in women with PCOS.

Retinoids can help treat skin pigmentation disorders by affecting melanin production.

Using CDK inhibitors on rats showed a reduction in chemotherapy-caused hair loss, but later experiments could not repeat these results.

New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Tyrosine kinase inhibitors effectively treat cancers but often cause skin and other side effects.

Metformin is effective for treating excessive hair growth in women with PCOS and may work better than the standard treatment in some ways.

Hit15 shows promise as a COVID-19 treatment by reducing virus infection and inflammation.

Methimazole can cause severe low platelet count in Graves' disease patients, so monitoring and alternative treatments are important.

Azithromycin and Roxithromycin can remove aging cells and may help with anti-aging.

Stilbamidine and hydroxystilbamidine inhibit enzyme release from lysosomes and have effects similar to cortisol and chloroquine.

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

A new treatment using nanoparticles can effectively prevent and reduce hair loss caused by chemotherapy.

Combining metformin with amoxicillin/clavulanate lowers blood sugar in diabetic female rats.

New isatin-gallate hybrids show promise as antioxidants, cancer treatments, and coronavirus inhibitors.

Chemicals called 4-(alkylthio)- and 4-(arylthio)-benzonitrile derivatives can potentially reduce oil production on skin, which could help treat conditions like acne and hair loss.

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.