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Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives

research Focused Review on Metal Nanoparticles in Hair Regeneration and Alopecia: Insights into Mechanisms, Assessment Techniques, Toxicity, Regulatory and Intellectual Property Perspectives

June 2025 in “Journal of Cluster Science”

Metal nanoparticles show promise for treating hair loss but need more research to ensure safety.

research scMC learns biological variation through the alignment of multiple single-cell genomics datasets

822 citations , January 2021 in “Genome biology”

scMC effectively separates biological signals from technical noise in single-cell genomics data.

research An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin

173 citations , August 2015 in “Developmental cell”

The study identified unique genes in hair follicle cells and their environment, suggesting these genes help organize cells for hair growth.

research LPA-producing enzyme PA-PLA₁α regulates hair follicle development by modulating EGFR signalling

151 citations , August 2011 in “The EMBO Journal”

The enzyme PA-PLA1α is important for proper hair follicle development.

research The Auxin-Regulated CrRLK1L Kinase ERULUS Controls Cell Wall Composition during Root Hair Tip Growth

109 citations , February 2018 in “CB/Current biology”

ERULUS controls root hair growth by regulating cell wall composition and pectin activity.

research In Human Skin, UVB Initiates Early Induction of IL-10 Over IL-12 Preferentially in the Expanding Dermal Monocytic/Macrophagic Population

101 citations , July 1998 in “Journal of Investigative Dermatology”

UVB exposure in human skin causes macrophages to produce more IL-10 and less IL-12, leading to immunosuppression.

research Wool Keratin-Associated Protein Genes in Sheep—A Review

98 citations , May 2016 in “Genes”

Understanding wool keratin-associated proteins in sheep can help improve wool quality through selective breeding.

research Challenges in the Physical Characterization of Lipid Nanoparticles

92 citations , April 2021 in “Pharmaceutics”

Characterizing lipid nanoparticles is challenging due to issues with sensitivity, reproducibility, and reliability.

research Hormone replacement therapy in morphine-induced hypogonadic male chronic pain patients

74 citations , January 2011 in “Reproductive Biology and Endocrinology”

Testosterone therapy can improve hormone levels and quality of life in men with morphine-induced hormone issues.

research Significance of stress keratin expression in normal and diseased epithelia

47 citations , January 2024 in “iScience”

Stress keratins are expressed less in diseased skin and are linked to differentiation, inflammation, and immunity.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells

39 citations , August 2022 in “Pharmaceutics”

Combining letrozole and quercetin in spanlastics may improve breast cancer treatment.

research Topical delivery of nanoemulsions for skin cancer treatment

34 citations , November 2023 in “Applied Materials Today”

Nanoemulsions can effectively treat skin cancer with fewer side effects.

research Progress in Topical and Transdermal Drug Delivery Research—Focus on Nanoformulations

32 citations , June 2024 in “Pharmaceutics”

Nanoformulations improve drug delivery through the skin, reducing side effects and enhancing effectiveness.

research Exploring the Antioxidant Potential of Blackberry and Raspberry Leaves: Phytochemical Analysis, Scavenging Activity, and In Vitro Polyphenol Bioaccessibility

12 citations , December 2023 in “Antioxidants”

Blackberry leaves have stronger antioxidant properties than raspberry leaves.

research Crystallin Fusion Proteins Improve the Thermal Properties of Hair

7 citations , October 2019 in “Frontiers in bioengineering and biotechnology”

Fusion proteins can protect hair from heat damage.

research The Effects of Lower vs Higher Cell Number of Platelet-Rich Plasma (PRP) on Hair Density and Diameter in Androgenetic Alopecia (AGA): A Randomized, Double-Blinded, Placebo, Parallel-Group Half-Scalp IRB-Approved Study.

6 citations , May 2021 in “Aesthetic Surgery Journal”

Higher cell number PRP improves hair density and diameter more than lower cell number PRP.

Exhaustive Analysis of Scalp Hair Regression: Subjective and Objective Perception from Initial Hair Loss to Severe Miniaturization and Drug-Induced Regrowth

research Exhaustive analysis of scalp hair regression: subjective and objective perception from initial hair loss to severe miniaturisation and drug-induced regrowth

3 citations , January 2021 in “Plastic and Aesthetic Research”

Hair loss reduces hair thickness and coverage, but drug treatments mainly revive dormant hairs rather than reverse thinning; patients often undervalue their hair loss severity.

research Finasteride interferes with prostaglandin-induced CatSper signalling in human sperm

2 citations , March 2021 in “Reproduction”

Finasteride may affect male fertility by interfering with specific sperm signaling.

research The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

1 citations , June 2022 in “Pharmaceutics”

Minoxidil's absorption is too variable for it to be a reliable reference drug.

Comparing Regenerative and Rehabilitative Strategies for Female Stress Urinary Incontinence: Platelet-Rich Plasma vs. Pelvic Floor Muscle Training—A Prospective Study Evaluating Quality of Life

research Comparing Regenerative and Rehabilitative Strategies for Female Stress Urinary Incontinence: Platelet-Rich Plasma vs. Pelvic Floor Muscle Training—A Prospective Study Evaluating Quality of Life

February 2026 in “Bioengineering”

Platelet-rich plasma treatment is more effective than pelvic floor muscle training for improving quality of life in women with stress urinary incontinence.

research Who Am I? Eyebrow Follicles Minimize Donor-Derived DNA for Germline Testing After Hematopoietic Stem Cell Transplantation

January 2026 in “International Journal of Molecular Sciences”

Eyebrow follicles are best for accurate genetic testing after stem cell transplants.

research Formulation and characterisation of resveratrol-loaded nanostructured lipid carriers for use in combination with scalp cooling therapy to mitigate chemotherapy-induced follicular cytotoxicity and hair loss

October 2025 in “Journal of Drug Delivery Science and Technology”

Resveratrol-loaded carriers may help reduce hair loss from chemotherapy when used with scalp cooling.

Exploring the Efficacy and Potential Mechanisms of Topical Periplaneta Americana Extract in Treating Androgenetic Alopecia in a Mouse Model: A Systems Pharmacology and Skin Microbiome Analysis

research Exploring the Efficacy and Potential Mechanisms of Topical Periplaneta americana (L.) Extract in Treating Androgenetic Alopecia in a Mouse Model: A Systems Pharmacology and Skin Microbiome Analysis

July 2025 in “Biology”

Periplaneta americana extract promotes hair growth and is safe for treating hair loss.

research Is autologous platelet-rich plasma capable of increasing hair density in patients with androgenic alopecia? A systematic review and meta-analysis of randomized clinical trials

July 2024 in “Anais Brasileiros de Dermatologia”

PRP injections can increase hair density in people with androgenic alopecia.

Carbon, Nitrogen, And Sulfur Elemental And Isotopic Variations In Mouse Hair And Bone Collagen During Short-Term Graded Calorie Restriction

research Carbon, nitrogen, and sulfur elemental and isotopic variations in mouse hair and bone collagen during short-term graded calorie restriction

May 2024 in “iScience”

Calorie restriction changes the elemental and isotopic makeup of mouse hair and bone.

Efficacy and Mechanism of Topical Shen Bai Hair Growing Decoction Against Androgenetic Alopecia

research Study on the Efficacy and Potential Mechanism of Topical Shen Bai Hair Growing Decoction against Androgenetic Alopecia Based on Ultrahigh Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and RNA-seq

February 2024 in “ACS Omega”

The Shen Bai Hair Growing Decoction may help treat hair loss by promoting hair growth and reducing inflammation.

research An mTurq2-Col4a1 mouse model allows for live visualization of mammalian basement membrane development

December 2023 in “The journal of cell biology/The Journal of cell biology”

The mTurq2-Col4a1 mouse model shows how the basement membrane develops in live mammals.

research Cross-kingdom delivery and putative gene modulation of androgen pathways by plant-derived exosome-like nanoparticles from polygoni multiflori radix promotes hair growth via miRNA cargo

November 2025 in “Pharmacological Research”

Plant-derived nanoparticles from Polygoni Multiflori Radix promote hair growth better than Minoxidil by affecting androgen pathways.

The Extract of Periplaneta Americana Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

research The Extract of Periplaneta americana (L.) Promotes Hair Regrowth in Mice with Alopecia by Regulating the FOXO/PI3K/AKT Signaling Pathway and Skin Microbiota

August 2025 in “Current Issues in Molecular Biology”

Periplaneta americana extract helps hair regrowth in mice with alopecia.

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