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PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.

p2y5, now called LPA6, is a receptor important for human hair growth.

*Acorus calamus* has many medicinal benefits but needs more safety research.

Alkaline ceramidase 1 is crucial for healthy skin and energy balance.

Canine hair follicle cells convert progesterone into various metabolites, mainly cortisol.

Activating cannabinoid receptor 1 may help manage psoriasis by reducing certain keratins.

Finasteride reduces DHT levels and affects gene expression in fish, similar to its effects in humans.

Chewing betel nut may increase the risk of type 2 diabetes, and saw palmetto can improve urinary symptoms in BPH with fewer side effects but may cause bleeding and allergic reactions.

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

A woman's rare scalp condition worsened after using a specific arthritis medication, suggesting such medications can sometimes trigger or aggravate psoriasis.

A new treatment for hair loss shows promise with fewer side effects.

Valproic acid is effective but often causes side effects like weight gain and hair loss, so personalized treatment is needed.

Anabolic-androgenic steroids harm male hormone levels, sperm, metabolism, and can cause acne, hair loss, and breast growth.

A specific gene change is linked to severe hair loss.

A special diet can fix hair problems in argininosuccinase deficiency.

Baricitinib for severe alopecia areata is generally safe, with common side effects like infections and acne, and low rates of serious complications.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Avacopan may cause unexpected side effects, so early monitoring is important.

Too much vitamin A can cause liver damage and skin issues.

Dihydroxyacetone in self-tanning lotion helped reduce sun-related skin issues in a woman with variegate porphyria.

The document concludes that various findings in rheumatology offer insights into disease severity, treatment responses, and potential risks in medication, with some limitations due to unspecified participant numbers.

Ruxolitinib reduced inflammation and improved symptoms in APECED patients but may cause anemia and weight gain.

PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.

Affected males are born with ambiguous genitalia, raised as females, but develop male traits at puberty due to enzyme deficiency.

Abrocitinib effectively treats severe alopecia areata with significant improvement and no side effects.

Targeting lipid metabolism can help treat advanced, resistant cancers.

Test liver enzymes and triglycerides every 5-6 months, and cholesterol levels in the first two months for acne patients on isotretinoin.

Male hormones can decrease the ability of immune cells to fight bacteria.