12 citations
,
January 2016 in “Skin appendage disorders” Repeated botulinum toxin injections for forehead wrinkles may cause hairline recession in some women.
December 2025 in “GeroScience” Genetics, epigenetics, and lifestyle all influence facial skin aging.
4 citations
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July 2024 in “Cureus” The treatment improved neck wrinkles and skin laxity.
November 2025 in “BMC Genomics” Wrinkled skin in Xiang pigs is linked to gene changes related to oxidative stress and the extracellular matrix.
66 citations
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June 1997 in “The Laryngoscope” Tailored treatments for aging brows and foreheads improve results.
3 citations
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January 2020 in “Plastic and Aesthetic Research” Non-surgical procedures can help reduce wrinkles and stimulate skin repair by understanding skin aging at the molecular level.
27 citations
,
May 2016 in “Dermatologic Surgery” Male faces age with more wrinkles and hair loss, influenced by both body changes and environmental factors.
April 2015 in “Experimental Dermatology” Melanoma risk tools need improvement, certain gene mutations cause skin diseases and could be treated by targeting those mutations, skin wrinkling may relate to lung aging due to genetic factors, and oxidative stress affects hair loss but can be reduced in low oxygen.
22 citations
,
September 2018 in “Medical Clinics of North America” Facial aging is caused by natural processes and external factors, and can be managed with preventative measures and a variety of treatments tailored to individual needs.
122 citations
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April 2020 in “American Journal Of Pathology” Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.
3 citations
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May 2011 in “Practice nursing” As skin ages, it gets thinner, paler, and more wrinkled, and protection and care like sunblock and moisturizers are important.
1 citations
,
July 2025 in “Journal of Cosmetic Dermatology” Lip aging differs from facial aging, needing specific care for barrier, wrinkles, and pigment changes.
9 citations
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June 2013 in “Journal of Cosmetic Dermatology” Lateral oblique forehead lines are caused by muscle movement, not sleep positions, and can be treated with botulinum toxin A.
14 citations
,
October 2021 in “Dermatology and Therapy” UV exposure accelerates skin aging by altering elastin, leading to wrinkles.
3 citations
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February 2025 in “Journal of PHYSIOLOGICAL ANTHROPOLOGY” Certain genes are linked to skin aging, like wrinkles and pigmentation changes.
20 citations
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June 2014 in “Pharmaceutical research” Using both hyaluronic acid compounds together improves skin hydration and reduces wrinkles better than using one alone.
5 citations
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April 2024 in “bioRxiv (Cold Spring Harbor Laboratory)” Aging skin shows thinner layers, fewer hair follicles, and new biomarkers like increased space between cells and smaller sebaceous glands.
5 citations
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July 2022 in “Frontiers in Medicine” Combining microneedle-delivered ECM and radiofrequency improves skin elasticity and thickness more than ECM alone.
March 2026 in “IP Indian Journal of Clinical and Experimental Dermatology” Wrinkles, dry skin, and hair changes are common in elderly skin, while infections and eczema are also prevalent.
4 citations
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November 2023 in “Journal of Cosmetic Dermatology” Negative pressure fractional microneedle radiofrequency effectively and safely reduces periorbital aging signs.
1 citations
,
May 2017 in “Journal of The American Academy of Dermatology” The moisturizer with phytol improved skin texture and reduced fine wrinkles better than the moisturizer without it.
18 citations
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February 2005 in “Facial plastic surgery” New cosmetic procedures effectively rejuvenate the lower face with minimal recovery time.
30 citations
,
August 2016 in “Skin research and technology” 3D imaging shows clearer details of skin structure changes with age.
July 2025 in “Journal of Investigative Dermatology” The new anti-aging ingredient improves skin hydration, elasticity, and reduces wrinkles.
3 citations
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January 1967 Testosterone slightly improved aging skin, while corticosteroids worsened it.
6 citations
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April 2018 in “Facial Plastic Surgery” Treating the temple area carefully with combined methods improves facial youthfulness.
9 citations
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February 2021 in “Frontiers in Cell and Developmental Biology” Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.
18 citations
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August 2017 in “PLOS ONE” Skin and its underlying fat layer act together to resist mechanical stress, and reinforcing this composite structure may help more with anti-aging than just strengthening the skin alone.
June 1996 in “Journal of Dermatological Science” Vitamin D3 applied to mouse skin caused more wrinkles and sagging due to changes in the skin's outer layer.
Skin ages and changes due to sun, wind, and aging, causing dryness, thinning, and hair loss.