Genetic Determinants of Skin Ageing: A Systematic Review and Meta-Analysis of Genome-Wide Association Studies and Candidate Genes

This systematic review and meta-analysis examined 48 studies to identify genetic loci associated with skin ageing phenotypes, such as wrinkling and pigmentation changes. It confirmed 30 loci linked to skin ageing, with some loci associated with specific phenotypic categories, indicating shared biological pathways. Despite heterogeneity and subjective phenotype assessments, the review underscores the importance of fundamental biological processes like development and cellular organization in skin ageing. Future research focusing on the same SNP across diverse populations could enhance the understanding of genetic contributions to skin ageing.