August 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.
June 2026 in “The Journal of Sexual Medicine” Rare seminoma found in a 33-year-old woman with atypical genitalia and no Y chromosome.
7 citations
,
April 2015 in “General and Comparative Endocrinology” Finasteride negatively affects fish reproduction and gonadal development.
June 2026 in “British Journal of Dermatology” Finasteride mildly affects semen but is reversible; dutasteride has stronger effects with incomplete recovery.
2 citations
,
December 2017 in “Theriogenology” Testosterone increases acidification in the vas deferens by up-regulating V-ATPase.
1 citations
,
August 2012 in “Archives of Gynecology and Obstetrics” Finasteride can help induce ovulation and lead to a healthy birth in some women.
7 citations
,
January 2009 in “DOAJ (DOAJ: Directory of Open Access Journals)” D-004 did not harm sperm cells in mice.
2 citations
,
March 2022 in “Laboratory Animal Research” A mild botulinum toxin injection improved sperm production and movement in aging mice.
34 citations
,
January 2004 in “Revista do Hospital das Clínicas” Finasteride may worsen infertility in men with existing issues, but stopping it can improve sperm health.
April 2026 in “The Journal of Urology” Finasteride and dutasteride reduce semen quality, with dutasteride having a stronger negative effect.
July 2007 in “Journal of Reproduction & Infertility” Short-term finasteride use likely doesn't harm male fertility.
6 citations
,
April 2009 in “Fertility and Sterility” Finasteride helps induce ovulation in nonresponder PCOS women.
35 citations
,
October 2004 in “Biology of Reproduction” PNU157706 reduced rat sperm movement and fertility without affecting offspring health.
23 citations
,
March 1998 in “BMJ” Haemochromatosis can cause infertility by affecting hormone glands.
31 citations
,
January 2001 in “PubMed” The combined treatment of Finasteride and Doxazosin affects prostate tissue by reducing cell growth and altering hormone levels.
2 citations
,
December 2016 in “Clinical and Experimental Obstetrics & Gynecology” Certain health factors can worsen fertility treatment results in women with PCOS.
1 citations
,
January 2023 in “International journal of urology” Low zinc levels are linked to low testosterone but not to sexual problems.
2 citations
,
December 2001 in “PubMed”
10 citations
,
December 2019 in “in Vivo” Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.
2 citations
,
September 2008 in “Fertility and Sterility” Adult offspring of sperm donation generally feel positive about their conception and view the donor as their biological father.
40 citations
,
January 1973 in “Journal of Dairy Science” Zinc deficiency in male goats leads to poor hair growth, smaller testicles, reduced libido, and is hard to reverse.
March 2013 in “Reactions Weekly” A man's fertility improved after he stopped taking finasteride but worsened again when he restarted the medication.
2 citations
,
October 1999 in “The Journal of Urology” 26 citations
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March 2001 in “PubMed” Men's fertility and sexual health decline with age, with reduced testosterone and virility, and many lose fertility by their eighties.
1 citations
,
January 2022 in “IntechOpen eBooks” Different PCOS types respond uniquely to infertility treatments, with some having lower pregnancy rates and higher risks of complications.
4 citations
,
December 2017 in “Journal of zoo and wildlife medicine” Hormonal changes during the reproductive cycle may cause seasonal skin problems in captive female fossas.
April 2019 in “Journal of the Endocrine Society” A 12-year-old boy with PAIS successfully developed male characteristics using high-dose testosterone and anastrozole.
Some drugs can reduce male semen quality.
Minoxidil may harm male reproductive health by causing testicular damage and hormonal disruption.