129 citations
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May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” A new staining method shows a special area in the hair's skin layer with lots of proteoglycans.
2 citations
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April 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The skin's basement membrane is specially designed to support different types of connections between skin layers and hair follicles.
72 citations
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November 2017 in “Journal of developmental biology” The Hedgehog signaling pathway is important for skin and hair growth and can lead to cancer if it doesn't work right.
March 2026 in “Preprints.org” Plerixafor may help treat pigmentation disorders by promoting skin repigmentation.
35 citations
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December 2008 in “PubMed” Trichilemmoma, BCC, and SCC tumors have different stem cell marker expressions.
152 citations
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December 2003 in “Micron” As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
110 citations
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August 2011 in “Journal of Visualized Experiments” 3D skin models better mimic human skin and melanoma progression than older methods.
March 2026 in “Frontiers in Cell and Developmental Biology” Understanding how certain proteins and genetic changes control skin stem cells is key to treating skin diseases.
1 citations
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July 2014 in “The journal of investigative dermatology/Journal of investigative dermatology” Light affects skin health, aging, and cancer risk, and new light-based treatments and imaging are promising for skin care.
5 citations
,
January 2021 in “Frontiers in cell and developmental biology” Skin cysts might help advance stem cell treatments to repair skin.
53 citations
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October 2003 in “Developmental Biology” Too much Sonic Hedgehog protein stops hair growth in embryos.
1 citations
,
December 2023 in “Life” PRP helps skin heal, possibly through special cells called telocytes.
1 citations
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December 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” Choosing the right method to separate skin layers is key for good skin cell research.
28 citations
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March 2010 in “Histochemistry and Cell Biology” Different markers are found in stem cells of the scalp's hair follicle bulge and the surrounding skin.
8 citations
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July 2015 in “European journal of histochemistry” Sox9 is present in most canine skin tumors and may help understand stem cells' role in these cancers.
December 2019 in “Medicina estética” Dermoscopy is underused in aesthetic medicine, but it increases diagnosis confidence; more training is needed.
December 2019 in “Medicina estética” Dermoscopy is underused in aesthetic medicine, but it increases diagnostic confidence, and professionals need more training.
198 citations
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March 1999 in “Journal of Investigative Dermatology” Keratin 15 helps maintain tissue integrity and is reduced in activated keratinocytes.
49 citations
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May 2021 in “Medicine” Understanding skin, hair, and nails is crucial due to their complexity and impact on health.
9 citations
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July 2022 in “Cell reports” Sox2 controls hair color by affecting pigment production in hair follicles.
August 2025 in “Annals of Medicine” Mycophenolate mofetil may safely help restore skin color in depigmentation conditions.
1 citations
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August 2024 in “Cosmetics” Melasma treatment is difficult, but combination therapies and personalized plans show promise.
August 2025 in “Journal of Cosmetic Dermatology” Topical treatments and lasers can improve axillary hyperpigmentation, but no best method is established yet.
21 citations
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December 2023 in “Journal of Investigative Dermatology” Hair graying is caused by damage and cell depletion but might be temporarily reversible with drugs and hormones.
20 citations
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November 2004 in “Archives of Pathology & Laboratory Medicine” A rare benign skin growth called melanocytic matricoma was identified in a 69-year-old man.
7 citations
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March 2017 in “Experimental and Therapeutic Medicine” Hair follicle cells can help keep embryonic stem cells undifferentiated.
June 2024 in “Stem cell research & therapy” Regenerative medicine shows promise for treating skin disorders like hair loss and vitiligo.
May 2024 in “International journal of molecular sciences” Platelet-derived products help regenerate tissue and are used in various skin and hair treatments.
April 2021 in “Indian Journal of Animal Research” Goat skin has collagen, elastic, and reticular fibers, with hair follicles increasing in depth as goats age.