research CRISPR–Cas9: A History of Its Discovery and Ethical Considerations of Its Use in Genome Editing
CRISPR-Cas9 allows precise DNA editing but raises ethical concerns about modifying human embryos.
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810-840 / 1000+ resultsresearch Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter
The system allows precise control of gene expression in mouse skin, useful for studying skin biology.
research PROTACs: A novel strategy for cancer drug discovery and development
PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.
research Conditional expression of the ErbB2 oncogene elicits reversible hyperplasia in stratified epithelia and up-regulation of TGFα expression in transgenic mice
research Tissue‐engineering approaches to enhance nerve regeneration during wound healing
Two methods improved nerve regeneration and touch recovery in skin grafts for burn patients.
research Regenerative medicine of the skin: Quantitative and qualitative analyses
Current skin substitutes don't fully replicate natural skin, and better understanding of molecular mechanisms is needed for improvement.
research Development of a Chitosan Nanofibrillar Scaffold for Skin Repair and Regeneration
Chitosan nanofiber scaffolds improve skin healing and are promising for wound treatment.
research Development of Pneumatic Dual-Cell Stacking Implanter
The new device can implant cell mixtures more effectively for hair loss treatment and is easier for operators to use.
research Smart hydrogel dressings for advanced wound healing: from biomaterial design to microenvironment modulation
Smart hydrogel dressings can improve healing for severe wounds by mimicking natural tissue and delivering treatments.
research A Cu@ZIF-8 encapsulated antibacterial and angiogenic microneedle array for promoting wound healing
The microneedle arrays effectively promote wound healing and have potential for clinical use.
research Injection/Application of Micrografts
Micrografts are useful for healing wounds, regenerating bone and periodontal tissues, and improving hair transplantation outcomes.
research 564 Subpopulations of dermal fibroblasts produce distinct extracellular matrices
Different types of skin cells create unique support structures that can affect skin cell growth and could help in skin repair.
research Leveraging Crosslinker Diffusion to Template Stiffness Gradients in Alginate Hydrogels
Stiffness gradients in alginate gels can guide cancer cell invasion and study cellular behaviors.
research EFFECTS OF HUMAN HAIR KERATIN ALKYLATION ON GROWTH FACTOR DELIVERY AND CELLULAR RESPONSE: IMPLICATIONS IN BONE REGENERATION
Alkylated keratin from human hair can help deliver growth factors for bone healing.
research “Bioprinting of Hair: How Far We Proceeded and What Needs to be Done”
3D bioprinting shows promise for hair regeneration but faces challenges in clinical application.
research An injectable photo-crosslinking silk hydrogel system with biphasic release of BTXA and 5-Fu promotes scarless wound healing
The hydrogel helps heal wounds without scars by releasing two drugs gradually.
research Engineered TGF-β-Enriched Exosomes Delivered by Dissolving Microneedles for Androgenetic Alopecia Therapy
research From Piezoelectric Nanogenerator to Non-Invasive Medical Sensor: A Review
Piezoelectric Nanogenerators are promising for non-invasive health monitoring but need efficiency and durability improvements.
research Stiffness-Controlled Thermoresponsive Hydrogels for Cell Harvesting with Sustained Mechanical Memory
The hydrogels help harvest cells while preserving their mechanical memory, which could improve wound healing.
research Development, Characterization, and Use of a Fetal Skin Cell Bank for Tissue Engineering in Wound Healing
Fetal skin cells from a cell bank heal wounds faster and with less scarring than adult cells.
research Corrigendum to ‘3D bioprinting of a gelatin-alginate hydrogel for tissue-engineered hair follicle regeneration’ [Acta Biomaterialia (2022)]
Corrections were made to a previous work on 3D printing a gel-alginate mix for creating hair follicles, but the main finding - that this method can help grow hair - remains the same.
research Differentiation Potential Analysis of Bone Marrow Mesenchymal Stem Cells from Guizhou Miniature Pigs
Bone marrow stem cells from Guizhou miniature pigs can grow well and become different cell types, useful for tissue engineering.
research Genetic targeting of lymphatic endothelial cells in mice: current strategies and future perspectives
Mouse models help target specific genes in lymphatic cells for research.
research Reconstitution of human skin in vitro using readily available sources: Novel studies of tumour promotion
A lab model of human skin was created to study skin tumor promoters without using actual human skin.
research The Promise of 3D Biomaterial Bioprinting for Wound-Healing and Skin Tissue Restoration
3D bioprinting shows great promise for improving wound healing and skin restoration.
research Cultured human skin fibroblasts: a model for the study of androgen action
research PEO-b-PCL grafted niosomes: The cooperativilty of amphiphilic components and their properties in vitro and in vivo
The new drug delivery systems made with surfactants and block polymers are stable and not toxic.
research Extracellular Vesicles in Osteogenesis: A Comprehensive Review of Mechanisms and Therapeutic Potential for Bone Regeneration
Extracellular vesicles can help regenerate bones but need more research for safe clinical use.
research CRISPR/Cas9-Mediated Generation of COL7A1-Deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa.
Scientists created a cell model to study and find treatments for a skin disease called RDEB.
research Nanotechnological Interventions and Mechanistic Insights into Wound-Healing Events
Nanotechnology can improve wound healing by enhancing treatments and dressings.