November 2022 in “Journal of Investigative Dermatology” Skin aging and cancer development are influenced by the competition between stem cells.
85 citations
,
July 2002 in “Pigment Cell Research” The article concludes that while we understand a lot about how melanocytes age and how this can prevent cancer, there are still unanswered questions about certain pathways and genes involved.
1 citations
,
June 2022 in “Experimental dermatology” The SHJH hr mice with a mutated Hr gene show signs of faster skin aging due to poor antioxidative protection.
240 citations
,
April 2011 in “Pigment Cell & Melanoma Research” Melanocyte stem cells in hair follicles are key for hair color and could help treat greying and pigment disorders.
73 citations
,
July 2016 in “Cosmetics” Mushrooms have beneficial properties for skin and hair care products and have great potential for future cosmetic use.
58 citations
,
February 2018 in “Journal of cosmetic dermatology” Estrogen helps keep skin healthy and may make women look younger and more attractive.
45 citations
,
August 2023 in “Trends in Cell Biology” Controlling cellular changes can enable safe rejuvenation without cancer risk.
21 citations
,
November 2023 in “International Journal of Molecular Sciences” Melatonin helps reduce aging signs in human eyelid skin.
20 citations
,
February 2019 in “Genes” The study concludes that mutations in the AEBP1 gene can cause a form of Ehlers-Danlos syndrome and should be considered in diagnosis.
4 citations
,
June 2023 in “Frontiers in Aging” Improving blood flow and oxygen levels in middle age may help prevent age-related diseases.
3 citations
,
October 2023 in “Cosmetics” Healthy lifestyle changes can significantly improve skin health as you age.
1 citations
,
November 2025 in “Aging Cell” EDA2R is a key gene linked to ageing and diseases, and targeting it may help treat conditions like hair loss and chronic diseases.
October 2025 in “JURNAL BIOLOGI TROPIS” Androgenetic alopecia is common hair loss due to genetics and hormones, manageable with early treatment.
April 2024 in “BMB Reports” Lack of Cisd2 disrupts calcium balance in cells, leading to poorly functioning neutrophils.
May 2013 in “Springer eBooks” Skin problems in the elderly are unique and may indicate other diseases, involving changes in skin, hair, nails, and increased cancer risk.
506 citations
,
January 2012 in “Molecular and Cellular Endocrinology” Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
158 citations
,
June 2017 in “Maturitas” Estrogen helps improve skin aging and healing, especially in post-menopausal women.
133 citations
,
September 2013 in “Nature Reviews Molecular Cell Biology” Different types of stem cells and their environments are key to skin repair and maintenance.
80 citations
,
April 2006 in “Clinical Interventions in Aging” Minoxidil and Finasteride are effective for male baldness; more research is needed for hair aging treatments.
77 citations
,
March 2014 in “Cold Spring Harbor Perspectives in Medicine” Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.
67 citations
,
June 2018 in “Engineering in Life Sciences” Plant cell culture is a promising method for creating sustainable and high-quality cosmetic ingredients.
55 citations
,
March 2010 in “Aging” Circadian clock genes are important for hair growth and may affect aging-related hair loss and graying.
41 citations
,
June 2018 in “Medicine Health Care and Philosophy” The article suggests using four questions to tell apart necessary medicalization from excessive medicalization, focusing on problem significance, social expectations, medical understanding, and effective resolution.
37 citations
,
March 2012 in “International Journal of Radiation Biology” Mobile phone radiation can cause DNA damage in human hair root cells.
29 citations
,
October 2019 in “Journal of dermatological science” Studying premature aging syndromes helps understand human aging and suggests potential treatments.
23 citations
,
July 2020 in “Aging Cell” Aging changes sugar molecules on skin stem cells, which may affect their ability to repair skin.
13 citations
,
January 2021 in “RSC chemical biology” Wnt activation shows promise for regenerative medicine but requires selective targeting to minimize risks like cancer.
12 citations
,
August 2022 in “Stem cell reviews and reports” Increasing PBX1 reduces aging and cell death in hair follicle stem cells by boosting SIRT1 and lowering PARP1 activity.
7 citations
,
October 2024 in “Cells” PRP therapy shows promise for anti-aging but lacks consistent evidence and standardization.
7 citations
,
November 2022 in “International Journal of Molecular Sciences” As Japanese males age, their hair darkens due to increased melanin, with males generally having darker hair than females.