research Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration
Dying cells can help with faster healing and new hair growth by releasing a growth-promoting molecule.
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research Conditioned media obtained from human outer root sheath follicular keratinocyte culture activates signalling pathways that contribute to maintenance of hair-inducing capacity and increases trichogenicity of cultured dermal cells
The substance from human hair root cells can help maintain hair growth and make skin cells more capable of growing hair.
research Differentiation Potential Analysis of Bone Marrow Mesenchymal Stem Cells from Guizhou Miniature Pigs
Bone marrow stem cells from Guizhou miniature pigs can grow well and become different cell types, useful for tissue engineering.
research 1393 Lower proximal cup cells but not bulge stem cells regenerate hair follicles after chemotherapy injury
Lower proximal cup cells, not bulge stem cells, regenerate hair follicles after chemotherapy.
research One-step generation of core–shell biomimetic microspheres encapsulating double-layer cells using microfluidics for hair regeneration
A new method efficiently creates cell spheres that help regenerate hair.
research 3D skin bioprinting: future potential for skin regeneration
research Abstract 3372: Mouse keratinocyte side-population plays an important role during malignant progression to skin squamous cell carcinomas
Mouse skin cancer progression involves a unique group of cells marked by ABCG2 and MTS24.
research 924 Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in iPS cells for recessive dystrophic epidermolysis bullosa
Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.
research Next generation human skin constructs as advanced tools for drug development
Advanced human skin models improve drug development and could replace animal testing.
research 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling
The study identifies a unique type of skeletal cell called lipochondrocytes (LCs) in facial cartilages, which resemble adipocytes but have stable lipid vacuoles crucial for tissue morphology and biomechanics. LCs, found near hair follicles, engage in signaling that affects hair growth. In mice, ear hair follicles enter a prolonged rest phase due to high levels of BMP5 and WNT antagonist WIF1 expressed by LCs. By altering BMP and WNT signaling, researchers were able to stimulate hair cycle re-entry in these follicles. This research highlights the role of skin-associated cartilage in modulating hair growth through specific signaling pathways.
research 567 Skin aging and carcinogenesis mechanisms by focusing on the stem cell competitive dynamics
Skin aging and cancer development are influenced by the competition between stem cells.
research DERMAL-EPIDERMAL INTERACTIONS
Hair loss is mainly caused by hormones, autoimmune issues, and chemotherapy, and needs more research for treatments.
research OCT4 maintains self-renewal and reverses senescence in human hair follicle mesenchymal stem cells through the downregulation of p21 by DNA methyltransferases
OCT4 helps hair stem cells renew and fight aging, potentially aiding hair regrowth.
research First symposium on natural gene therapy of the skin
Natural gene therapy shows promise for treating skin disorders like epidermolysis bullosa.
research Future Directions: The Known and Unknown Roles of Hair-Follicle Stem Cell Types
research Integrin α3β1 in hair bulge stem cells modulates CCN2 expression and promotes skin tumorigenesis
Removing integrin α3β1 from hair stem cells lowers skin tumor growth by affecting CCN2 protein levels.
research Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapies
New treatments targeting skin stem cells show promise for skin repair, anti-aging, and cancer therapy.
research Peer Review #1 of "Establishment of an immortalized mouse dermal papilla cell strain with optimized culture strategy (v0.1)"
Scientists improved how to grow mouse skin cells in the lab and created a long-lasting cell line, but didn't fully explain its advantages or compare it to normal cells.
research Molecular and spatial design of early skin development
The research reveals how early embryonic mouse skin develops from simple to complex structures, identifying various cell types and their roles in this process.
research 881 Ionizing radiation triggers dedifferentiation of outer root sheath cells into stem cell-like progenitors for hair follicle regeneration
research Transdifferentiation of corneal epithelium into epidermis occurs by means of a multistep process triggered by dermal developmental signals
Corneal cells can transform into skin and hair cells through specific signals.
research Vital roles of stem cells and biomaterials in skin tissue engineering
Stem cells and biomaterials are key to improving skin substitutes for medical use.
research Canine Epidermal Neural Crest Stem Cells: Characterization and Potential as Therapy Candidate for a Large Animal Model of Spinal Cord Injury
Canine epidermal neural crest stem cells could be a promising treatment for spinal cord injuries in dogs.
research 905 Dysfunction of hair follicle mesenchymal progenitors is associated with age-related hair loss
Age-related hair loss is linked to the decline and dysfunction of hair follicle stem cells.
research GDNF promotes hair formation and cutaneous wound healing by targeting bulge stem cells
GDNF helps grow hair and heal skin wounds by acting on hair stem cells.
research Recreation of a hair follicle regenerative microenvironment: Successes and pitfalls
Hair growth environment recreated with challenges; stem cells make successful skin organoids.
research Relation between dermal papilla cells and androgenetic alopecia
Dermal papilla cells play a key role in hair loss by responding to androgens.
research Regulation of melanocyte stem cells in the pigmentation of skin and its appendages: Biological patterning and therapeutic potentials
Understanding how melanocyte stem cells work could lead to new treatments for hair graying and skin pigmentation disorders.
research 655 In vitro cultivation of dermal-epidermal composites in a single medium supports human hair follicle neogenesis in xenografts
A single medium, PRIME AIRLIFT, supports better human hair follicle formation in grafts.
research HB-EGF Improves the Hair Regenerative Potential of Adipose-Derived Stem Cells via ROS Generation and Hck Phosphorylation
HB-EGF boosts the hair growth ability of stem cells, making it a potential hair loss treatment.