research Peptide-Based PROTACs: Transitioning from Static Paradigm to a Dynamic Landscape within Targeted Protein Degradation
Peptide-based PROTACs show promise in targeting hard-to-treat proteins, especially for cancer therapy.
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research Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration after Extensive Liver Resection in Rats
Using a drug to activate bone marrow stem cells can help the liver regenerate and function better after major surgery in rats.
research Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, p2y5/LPA6
p2y5, now called LPA6, is a receptor important for human hair growth.
research Weathering the Storm: Harnessing the Resolution of Inflammation to Limit COVID-19 Pathogenesis
Reprogramming macrophages to resolve inflammation can help reduce severe COVID-19 complications.
research Protein degradation: expanding the toolbox to restrain cancer drug resistance
Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.
research Melatonin regulates the periodic growth of secondary hair follicles through the nuclear receptor RORα
Melatonin helps hair grow by activating the RORα receptor in goats.
research Pigmentary mosaicism: An update
Pigmentary mosaicism causes skin color changes and can affect multiple body systems, but has no cure.
research Membranous nephropathy and lupus-like syndrome after hematopoietic cell transplantation: a case report
A man developed autoimmune issues after a transplant, improved with treatment, but died from leukemia relapse.
research Enhancing Permeation of Drug Molecules Across the Skin via Delivery in Nanocarriers: Novel Strategies for Effective Transdermal Applications
Nanocarriers can improve drug delivery through the skin by overcoming barriers.
research Targeted Inactivation of Gh/Tissue Transglutaminase II
Tgm2 helps stabilize dying cells and aids fibroblast attachment to the extracellular matrix.
research Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases
More precise, personalized therapies are needed for autoimmune diseases.
research Nanotechnology Approaches in Chronic Wound Healing
Nanotechnology shows promise for better chronic wound healing but needs more research.
research The RpoS Gatekeeper in Borrelia burgdorferi: An Invariant Regulatory Scheme That Promotes Spirochete Persistence in Reservoir Hosts and Niche Diversity
RpoS helps Borrelia burgdorferi survive in hosts and adapt to different environments.
research Targeting integrin pathways: mechanisms and advances in therapy
New therapies are being developed that target integrin pathways to treat various diseases.
research Loss of epidermal Evi/Wls results in a phenotype resembling psoriasiform dermatitis
Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
research Topical drug delivery strategies for enhancing drug effectiveness by skin barriers, drug delivery systems and individualized dosing
Improving topical drug delivery involves overcoming skin barriers and using personalized dosing to enhance effectiveness.
research Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut
Gut bacteria can lower androgen levels in male mice.
research Catalytic Antibodies in Norm and Systemic Lupus Erythematosus
Catalytic antibodies are early indicators and active participants in the development of systemic lupus erythematosus.
research Diverse origins of fibrinolytic enzymes: A comprehensive review
Exploring fermented foods from various regions can lead to discovering new fibrinolytic enzymes.
research Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches
New treatments like nanotechnology show promise in improving skin cancer therapy.
research Inflammatory bowel disease: pathogenesis, diagnosis and current therapeutic approach
IBD treatment is complex and requires personalized approaches due to varying patient responses.
research Native and engineered extracellular vesicles for wound healing
Extracellular vesicles show promise for wound healing, but more research is needed to improve their stability and production.
research Oral Lichen Planus
Oral lichen planus is a chronic disease causing mouth discomfort and sometimes needs immunosuppressive treatment.
research Eyes open on stem cells
Stem cells in the cornea show unexpected flexibility and have important implications for medicine.
research A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling
Certain immune cells worsen post-surgery gut paralysis by activating a specific immune response.
research Folate receptor β performs an immune checkpoint function in activated macrophages
Folate receptor β helps suppress the immune system in macrophages and affects cancer growth and hair health.
research Causes and therapeutic limitations of clinical alopecia and the advent of human pluripotent stem cell follicular transplantation
Stem cell technology may improve hair loss treatments by providing more effective and personalized options.
research Morphologic Markers of Acute and Chronic Stress in Child Abuse
The conclusion is that certain physical signs in the body can indicate past acute and chronic stress, which may help in child abuse investigations.
research Progress in the Expression, Purification, and Characterization of Recombinant Collagen
Recombinant collagen is promising for biomaterials, pharmaceuticals, and skincare due to its benefits and potential improvements.
research Microneedle-Mediated Transdermal Drug Delivery for the Treatment of Multiple Skin Diseases
Microneedles improve drug delivery for skin diseases, enhancing treatment effectiveness and patient compliance.