research Biomaterials Functionalized with MSC Secreted Extracellular Vesicles and Soluble Factors for Tissue Regeneration
Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.
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research A matter of life and death: self‐renewal in stem cells
Stem cell self-renewal is complex and needs more research for full understanding.
research Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men
Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.
research Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair
Fat cells in the skin help start healing and form important repair cells after injury.
research Microenvironmental reprogramming of thymic epithelial cells to skin multipotent stem cells
Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
research Development and homeostasis of the sebaceous gland
The document concludes that understanding the sebaceous gland's development and function is key to addressing related skin diseases and aging effects.
research Fullerene nanoparticle in dermatological and cosmetic applications
Fullerenes show potential in skin care but need more safety research.
research 9 Role of 5α-reductase in health and disease
5α-reductase is essential for male sexual development and its inhibitors have potential in treating various conditions related to hormone action.
research Wnt/β‐catenin pathway in tissue injury: roles in pathology and therapeutic opportunities for regeneration
The Wnt/β-catenin pathway helps tissue regeneration but can also cause fibrosis, and drugs that inhibit this pathway may aid in healing skin and heart tissues.
research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression (Catagen) by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla
All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.
research Histopathologic Evaluation of Alopecias
The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.
research Epidemiology of skin cancer in the mature patient
Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.
research Learning from nudity: lessons from the nude phenotype
The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
research Epidermal stem cells and skin tissue engineering in hair follicle regeneration
Hair follicle regeneration needs special conditions and young cells.
research Trichoblastic Carcinoma (“Malignant Trichoblastoma”) with Lymphatic and Hematogenous Metastases
Long-standing benign tumors can become cancerous, especially in people with weakened immune systems.
research Review of Hair Follicle Dermal Papilla cells as in vitro screening model for hair growth
Dermal Papilla cells are a promising tool for evaluating hair growth treatments.
research Exosomes and Their Bioengineering Strategies in the Cutaneous Wound Healing and Related Complications: Current Knowledge and Future Perspectives
Engineered exosomes show promise for improving wound healing but face challenges in clinical use.
research Potential adverse effects of long-term testosterone therapy
Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.
research From neural crest cells to melanocytes: cellular plasticity during development and beyond
Melanocyte development from neural crest cells is complex and influenced by many factors, and better understanding could help treat skin disorders.
research Mechanical forces in skin disorders
Skin problems can be caused or worsened by physical forces and pressure on the skin.
research Current applications of high-frequency ultrasonography in dermatology
High-frequency ultrasonography is a useful but underused tool in dermatology for assessing skin cancers, monitoring diseases, and evaluating treatments.
research Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation
Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.
research Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
research The Paradox of p53: What, How, and Why?
The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.
research Acute diffuse and total alopecia: A new subtype of alopecia areata with a favorable prognosis
A new type of rapid hair loss called ADTA usually gets better on its own within 6 months.
research Apoptosis and cutaneous biology
Apoptosis is crucial for healthy skin and treating skin diseases.
research Unmet Medical Needs in Chronic, Non-communicable Inflammatory Skin Diseases
There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.
research Choreographing Immunity in the Skin Epithelial Barrier
The document concludes that the skin's immune system is complex, involving interactions with hair follicles, nerves, and microbes, and can protect or cause disease, offering targets for new treatments.
research The therapeutic use of androgens in women
Testosterone replacement may improve sexual desire and bone health in women with low androgen levels, but more research is needed on its long-term safety.
research JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin
JunB is crucial for maintaining healthy skin and hair follicles.