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The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

Androgens and androgen receptors are important for metabolic health, affecting how the body uses glucose and fats through mitochondrial function.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Depressed teens have different steroid levels in urine, which may help identify and treat them.

Taking 5α-reductase inhibitors with prednisolone can worsen its negative effects on metabolism.

Human skin produces sex hormones like estrogen and testosterone, influenced by ARO and StAR, which may affect skin elasticity and hair growth.

The study created a new method to test drugs that affect hormone processing in skin.

Epristeride's metabolism in zebrafish helps improve doping detection methods.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

Testosterone conversion to 5α-DHT may not be essential for its effects on the skin.

Human adrenals and gonads have a unique enzyme for steroid hormone production.

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

Androgens may increase arrhythmias in Brugada Syndrome, while Finasteride could reduce them.

The inhibitor affects androgen metabolism but not ovarian function.

Human skin can produce steroids from cholesterol.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Cortisol increases a specific protein in bone cells, which may help explain its negative effects on bone.

Beta-sitosterol has potential health benefits but needs more research to fully understand its effects and improve its use in treatments.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Mutations in certain receptors can cause diseases and offer new treatment options.

Croton membranaceus root extract can change how drugs are processed in the body.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.