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GlossaryBreast Cancer

malignancy originating in breast tissue cells

Breast cancer, also known as breast carcinoma, is a type of malignancy that originates in the cells of the breast tissue. It can develop in the ducts (ductal carcinoma) or lobules (lobular carcinoma) and may spread to other parts of the body if not detected and treated early. Early detection through screening methods like mammograms significantly improves the prognosis.

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Matriptase Activation and Shedding with HAI-1 Induced by Steroid Sex Hormones in Human Prostate Cancer Cells, but Not in Breast Cancer Cells

research Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells

56 citations , February 2006 in “American journal of physiology. Cell physiology”

Steroid sex hormones activate matriptase in prostate cancer cells but not in breast cancer cells.

research Polyamine Oxidase Expression Is Downregulated by 17β-Estradiol via Estrogen Receptor 2 in Human MCF-7 Breast Cancer Cells

8 citations , July 2022 in “International Journal of Molecular Sciences”

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

research 202 Activation of breast cancer cell proliferation by ROR-alpha through aromatase promoter

March 2010 in “Ejc Supplements”

ROR-alpha may increase the growth of certain breast cancer cells by boosting aromatase, which could affect breast cancer prognosis.

research Glibenclamide inhibits cell growth by inducing G0/G1 arrest in the human breast cancer cell line MDA-MB-231

68 citations , January 2013 in “BMC Pharmacology and Toxicology”

Glibenclamide slows breast cancer cell growth by stopping cell division.

research Invasion and increased expression of S100A4 and CYR61 in mesenchymal transformed breast cancer cells is downregulated by GnRH

21 citations , April 2016 in “International Journal of Oncology”

GnRH treatment can reduce breast cancer cell invasion.

research Anti-invasive effects of minoxidil on human breast cancer cells: combination with ranolazine

5 citations , May 2022 in “Clinical & Experimental Metastasis”

Minoxidil and ranolazine together can reduce the spread of certain breast cancer cells.

research Combinatorial Therapy of Letrozole- and Quercetin-Loaded Spanlastics for Enhanced Cytotoxicity against MCF-7 Breast Cancer Cells

39 citations , August 2022 in “Pharmaceutics”

Combining letrozole and quercetin in spanlastics may improve breast cancer treatment.

Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma

research Fibroblast heterogeneity and functions: insights from single-cell sequencing in wound healing, breast cancer, ovarian cancer and melanoma

March 2024 in “Frontiers in genetics”

Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.

research Transcription Regulation and Protein Subcellular Localization of the Truncated Basic Hair Keratin hHb1-ΔN in Human Breast Cancer Cells

8 citations , June 2001 in “Journal of Biological Chemistry”

A truncated protein linked to breast cancer may change cell adhesion.

research Cosmos caudatus Kunth. Leaf Extract Herbal Nanosuspension Formulations, Characterization, and Cytotoxicity Approach Against MCF-7 Breast Cancer Cells

2 citations , October 2023 in “JURNAL ILMU KEFARMASIAN INDONESIA”

Kenikir leaf extract nanosuspension may help inhibit breast cancer cell growth.

In Vitro Anti-Proliferative and Antioxidant Activities of Chloroform Extract of Christia Vespertilionis on MCF-7 and MDA-MB-231 Breast Cancer Cells

research In vitro anti-proliferative and antioxidant activites of chloroform extract of christia vespertilionis on mcf 7 and mda-mb-231 breast cancer cells

January 2025 in “UiTM Institutional Repositories (Universiti Teknologi MARA)”

Christia vespertilionis extract may help fight breast cancer cells.

research An Approach to Identify Targets of Breast Cancer Stem Cells

September 2007 in “MacSphere (McMaster University)”

New biomarkers and targets for breast cancer treatment were identified to help prevent relapse and metastasis.

Nutraceuticals Known to Promote Hair Growth Do Not Interfere with the Inhibitory Action of Tamoxifen in MCF7, T47D, and BT483 Breast Cancer Cell Lines

research Nutraceuticals Known To Promote Hair Growth Do Not Interfere With The Inhibitory Action of Tamoxifen In MCF7, T47D And BT483 Breast Cancer Cell Lines

February 2022 in “Research Square (Research Square)”

Certain nutraceuticals may enhance hair growth without affecting the cancer-fighting properties of tamoxifen.

Polymeric Nanocapsular Baicalin: Chemometric Optimization, Physicochemical Characterization, and Mechanistic Anticancer Approaches on Breast Cancer Cell Lines

research Polymeric nanocapsular baicalin: Chemometric optimization, physicochemical characterization and mechanistic anticancer approaches on breast cancer cell lines

76 citations , July 2019 in “Scientific Reports”

Baicalin nanocapsules greatly enhance its anticancer effects on breast cancer cells.

research Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness

24 citations , April 2017 in “Oncology Reports”

The hair keratin gene KRT81 is found in both normal and breast cancer cells and helps them invade surrounding tissues.

research Nutraceuticals known to promote hair growth do not interfere with the inhibitory action of tamoxifen in MCF7, T47D and BT483 breast cancer cell lines

February 2024 in “PloS one”

Nutraceuticals that promote hair growth do not reduce tamoxifen's effectiveness in breast cancer treatment.

research Selective Androgen Receptor Modulators (SARMs) Negatively Regulate Triple-Negative Breast Cancer Growth and Epithelial:Mesenchymal Stem Cell Signaling

56 citations , July 2014 in “PloS one”

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

research LB822 Nutraceuticals known to promote hair growth do not interfere with the inhibitory action of tamoxifen in breast cancer cells

August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Hair growth supplements do not reduce the effectiveness of the breast cancer treatment tamoxifen.

research Nutraceuticals Known to Promote Hair Growth Do not Interfere with the Inhibitory Action of Tamoxifen in MCF7, T47D and BT483 Breast Cancer Cell Lines

December 2021 in “Research Square (Research Square)”

Hair growth-promoting nutraceuticals do not block the cancer-fighting effects of tamoxifen and may enhance its action.

A Discrete Transition Zone Between Cuticle and Cortex Layers of a Human Hair Fiber: Changes Observed in the Presence of Breast Cancer

research A discrete transition zone between cuticle and cortex layers of a human hair fibre: changes observed in the presence of breast cancer

1 citations , October 2017 in “ecancermedicalscience”

Breast cancer alters specific molecular structures in hair, which revert after cancer removal.

research Vitamin D and androgen receptor-targeted therapy for triple-negative breast cancer

59 citations , April 2016 in “Breast Cancer Research and Treatment”

Targeting vitamin D and androgen receptors may effectively treat triple-negative breast cancer, especially with chemotherapy.

Permanent Alopecia in Patients with Breast Cancer After Taxane Chemotherapy and Adjuvant Hormonal Therapy: Clinicopathologic Findings in a Cohort of 10 Patients

research Permanent alopecia in patients with breast cancer after taxane chemotherapy and adjuvant hormonal therapy: Clinicopathologic findings in a cohort of 10 patients

31 citations , March 2017 in “Journal of The American Academy of Dermatology”

Some breast cancer patients developed permanent hair loss after chemotherapy and hormonal therapy, showing patterns similar to common baldness and alopecia areata.

research Abstract P5-09-21: Selective androgen receptor modulators (SARMs): Enobosarm as targeted therapy for the treatment of androgen receptor-positive breast cancer

2 citations , December 2013 in “Cancer research”

Enobosarm may effectively treat androgen receptor-positive breast cancer with fewer side effects.

research SAT-724 Persistently Elevated Alkaline Phosphatase in an Older Woman with a History of Breast Cancer

October 2025 in “Journal of the Endocrine Society”

Stopping Viviscal, a hair loss product, normalized the woman's elevated alkaline phosphatase levels.

Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

research Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity

November 2023 in “Advanced Science”

A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.

research 200 The relationship between the expression of cytokeratin 5/6 and clinicopathologic factors in invasive breast carcinoma