21 citations
,
January 2017 in “Skin Pharmacology and Physiology” Caffeine-based liquid 0.2% is as effective as minoxidil 5% for treating male hair loss.
1 citations
,
February 2025 in “Supportive Care in Cancer” Safe treatments like minoxidil and spironolactone can help manage hair loss in breast cancer patients without increasing cancer risk.
December 2024 in “Skin Appendage Disorders” Non-prescription products can help manage androgenic alopecia.
January 2022 in “DOAJ (DOAJ: Directory of Open Access Journals)” Argan oil-based nano carriers could potentially deliver caffeine to hair follicles to treat hair loss.
1 citations
,
July 2023 in “Cureus” Some treatments for hereditary hair loss are effective but vary in results and side effects; new therapies show promise but need more research.
31 citations
,
February 2019 in “International Journal of Cosmetic Science” Caffeine applied to the scalp can protect hair follicles from UV damage.
5 citations
,
January 2020 in “Journal of Dermatology and Dermatologic Surgery” Caffeine may benefit skin and hair health but more research is needed to confirm its effectiveness in dermatology.
September 2025 in “medRxiv (Cold Spring Harbor Laboratory)” Using Centella asiatica EV and growth factors improves scalp health and hair growth.
September 2014 in “Hair transplant forum international” Caffeine, niacinamide, and panthenol may improve hair growth, fullness, and healing when applied to the scalp.
14 citations
,
October 2020 in “Natural Products and Bioprospecting” Various treatments, including FDA-approved drugs, natural products, and oral supplements, can help with hair loss, but a patient's medical history and potential allergies should be considered when choosing a treatment.
40 citations
,
August 2018 in “Skin appendage disorders” Some alternative treatments for hair loss might work, but more research is needed.
1 citations
,
July 2017 in “Journal der Deutschen Dermatologischen Gesellschaft” Topical caffeine improves hair loss intensity, speed, and shedding, and works better with minoxidil/azelaic acid.
82 citations
,
May 2009 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Caffeine penetrates human skin in lab tests similarly to real-life conditions, but actual skin use is still essential for accurate results.
35 citations
,
January 2018 in “Skin pharmacology and physiology” Nanoemulsion creams with certain enhancers can greatly increase caffeine delivery through skin.
January 2026 in “Frontiers in Medicine” PP-PTKL may help treat hair greying, but more testing is needed.
7 citations
,
October 2024 in “AAPS PharmSciTech” CA-SLN-Ngel significantly reduces cellulite more effectively than regular caffeine gel.
December 2022 in “Clinical and experimental dermatology and therapies” Adding the topical gel improved hair growth more than using minoxidil or finasteride alone.
8 citations
,
January 2020 in “Skin Pharmacology and Physiology” Caffeine improves hair growth, thickness, and reduces shedding.
November 2023 in “Journal of Cosmetic Dermatology” The topical treatment with caffeine and Procapil 3% improved male pattern hair loss and was well tolerated after 12 weeks.
182 citations
,
December 2007 in “BJCP. British journal of clinical pharmacology/British journal of clinical pharmacology” Hair follicles significantly increase the speed and amount of caffeine absorbed through the skin.
10 citations
,
July 2021 in “European journal of pharmaceutics and biopharmaceutics” Nanoparticles sized between 470 and 750 nm are best for delivering substances like caffeine into hair follicles for absorption.
1 citations
,
February 2020 in “PubMed” The topical solution improved hair density and appearance in men with androgenetic alopecia.
March 2026 in “Journal of the American Academy of Dermatology” A holistic approach, including diet and stress management, may improve androgenetic alopecia treatment outcomes.
August 2025 in “Journal of Cosmetic Dermatology” The shampoo with DMG-Na and caffeine effectively reduces hair loss and improves hair density in men.
145 citations
,
November 2017 in “Journal of The European Academy of Dermatology and Venereology” Use minoxidil for hair loss treatment; assess results after 6 months.
39 citations
,
April 2011 in “Recent Patents on Drug Delivery & Formulation” Nanoemulsion-based drug delivery systems are versatile and have potential for treating various medical conditions and improving vaccines.
15 citations
,
October 2020 in “European journal of pharmaceutics and biopharmaceutics” Caffeine penetrates skin quickly through open hair follicles, but less through closed ones, with levels becoming equal after 22 hours.
Removing follicular plugging is crucial for effective alopecia treatment.
November 2013 in “Journal of Mazandaran University of Medical Sciences” Minoxidil with caffeine works better for hair loss than minoxidil alone.
December 2023 in “Azerbaijan Pharmaceutical and Pharmacotherapy J” The minoxidil gel could be a better treatment for hair loss than traditional forms.