The gene Endothelin 3 makes mice's fur darker by increasing pigment cells and pigment levels.
2 citations
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May 2019 in “International Journal of Molecular Sciences” Tranexamic acid turns white hair brown in certain mice by affecting specific proteins.
March 2013 in “Pigment Cell & Melanoma Research” A gene called Taqpep affects cat coat patterns like stripes and blotches.
3 citations
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October 2020 in “Journal of Investigative Dermatology” Removing β-catenin in certain stem cells causes hair whitening and pigmentation issues.
Marine macroalgae contain compounds that can improve skin health and have cosmetic benefits.
7 citations
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April 1996 in “Archives of dermatological research” Topical tacalcitol can treat psoriasis by acting directly on skin cells.
2 citations
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March 2017 in “Asian Journal of Beauty and Cosmetology” Caffeic acid protects human scalp cells from UV damage.
3 citations
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January 2016 in “Recent Advances in Biology and Medicine” Smeathxanthone A improves wound healing and lowers blood sugar in diabetic mice.
January 2024 in “Journal of Pharmacognosy and Phytochemistry” Catharanthus roseus and Schwenckia americana extracts are generally safe but may cause kidney and liver tissue damage.
37 citations
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January 2015 in “Evidence-based Complementary and Alternative Medicine” An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Activating β-catenin increases melanocytes and decreases Schwann cells.
TBX3 gene affects horse coat color, with higher expression in darker areas.
19 citations
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January 2016 in “Biological & Pharmaceutical Bulletin” Sargassum muticum extract and its component apo-9'-fucoxanthinone may help hair growth and treat hair loss.
21 citations
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September 2013 in “Current medicinal chemistry” HAC and BAC improve skin targeting and reduce diffusion without causing irritation.
27 citations
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August 2006 in “Laboratory Investigation” SCF and ET-1 together significantly increase skin pigmentation and melanin production.
June 2025 in “BMJ Case Reports” Axitinib treatment turned a man's grey hair back to black.
15 citations
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January 2022 in “Journal of Oleo Science” Phytosomal nanocarriers can significantly increase the bioavailability of Cuscuta reflexa extract.
March 2026 in “Molecules” Camellia sinensis seed flavonoids can reduce skin inflammation and damage from UV rays.
December 2025 in “Sustainable Chemistry One World” Mangosteen waste can be used as an eco-friendly natural hair dye, producing a lasting reddish color and strengthening hair.
5 citations
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September 2022 in “Antioxidants” A substance from Caulerpa racemosa seaweed may protect against skin damage caused by air pollution by reducing oxidative stress and cell death.
2 citations
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January 2002 Melanin and melanocytes contribute to the brown pigmentation in stasis dermatitis.
3 citations
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May 2021 in “Genetics and Biodiversity Journal” Citrullus colocynthis fruit extract has strong antioxidant and cancer-fighting potential.
ACA from Alpinia galanga may prevent testosterone-related hair loss.
42 citations
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June 2019 in “Aging” 3,4,5-tri-O-caffeoylquinic acid promotes hair growth by activating the β-catenin pathway.
1 citations
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May 2025 in “Discover Chemistry.” Improving mangiferin's solubility and delivery can enhance its health benefits.
December 2025 in “Biomedicine & Pharmacotherapy” Melamax® protects skin from UV damage and reduces inflammation and oxidative stress.
12 citations
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December 1981 in “Journal of Endocrinology” α-MSH increases melanin production in moulting hair follicles, while AVT inhibits it.
19 citations
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January 2009 in “OpenSIUC (Southern Illinois University Carbondale)” Calotropis gigantea and Tridax procumbens extracts reduce inflammation more effectively than low-dose Ibuprofen.
6 citations
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September 2022 in “Frontiers in pharmacology” Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.