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GlossaryCardiac Function

ability of the heart to pump blood throughout the body

Cardiac function, also known as heart function or cardiac performance, refers to the ability of the heart to pump blood effectively throughout the body. It encompasses various parameters such as heart rate, stroke volume (the amount of blood pumped per beat), and cardiac output (the total volume of blood pumped per minute). Proper cardiac function is crucial for delivering oxygen and nutrients to tissues and removing waste products, ensuring overall bodily health and function.

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Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice

research Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice

13 citations , August 2018 in “Journal of Molecular and Cellular Cardiology”

Finasteride improves heart function and repairs damage after heart attack in mice.

Finasteride Effectively Attenuates the Impairments of Left Ventricular Function and Cardiac Sympathovagal Balance in Both Aging and Obese Male Rats via Reducing Systemic Oxidative Stress

research Finasteride effectively attenuates the impairments of left ventricular function and cardiac sympathovagal balance in both aging and obese male rats via reducing systemic oxidative stress

November 2023 in “European heart journal”

Finasteride improves heart function and balance in aging and obese male rats by reducing oxidative stress.

research Loss‐of‐function of Endothelin receptor type A results in Oro‐Oto‐Cardiac syndrome

11 citations , March 2020 in “American Journal of Medical Genetics Part A”

A mutation in the EDNRA gene causes Oro-Oto-Cardiac syndrome, affecting face and heart development.

research Ion Sequential Therapy Aligned With Pathological Changes Enhances Cardiac Function After Myocardial Infarction

September 2024

Ion sequential therapy improves heart function after a heart attack.

research Influence of tamsulosin and finasteride on circadian rhythm and cardiac function in male elderly patients with chronic heart failure

January 2014 in “Shiyong laonian yixue”

Tamsulosin and finasteride improve heart function and circadian rhythm in elderly men with heart failure and prostate issues.

Corrigendum to 'Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling and Reverts Pathologic Gene-Expression After Myocardial Infarction in Mice'

research Corrigendum to “Anti-androgenic therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice” Journal of Molecular and Cellular Cardiology 122 (2018) 114–124

November 2018 in “Journal of Molecular and Cellular Cardiology”

Finasteride improves heart function and repairs damage after heart attack in mice.

research Metoprolol-spironolactone combination for coronary heart disease with concurrent heart failure: impact on cardiac function

January 2026 in “American Journal of Translational Research”

The metoprolol-spironolactone combination improves heart function in patients with coronary heart disease and heart failure.

research Abstract 153: Inhibition of the 5-a-reductase Reduces Cardiac Hypertrophy and Improves Cardiac Function

August 2013 in “Circulation Research”

Finasteride reduces heart enlargement and improves heart function.

research Exploring pericyte and cardiac stem cell secretome unveils new tactics for drug discovery

26 citations , December 2016 in “Pharmacology & Therapeutics”

New drugs for heart disease may be developed from molecules secreted by stem cells.

Cardiac Flow Parameters with Conventional and Pulsed Tissue Doppler Echocardiography Imaging in Patients with Polycystic Ovary Syndrome

research Cardiac flow parameters with conventional and pulsed tissue Doppler echocardiography imaging in patients with polycystic ovary syndrome

9 citations , May 2010 in “Gynecological Endocrinology”

Young women with PCOS and no other heart risk factors have normal heart function.

research The Multifaceted Functions of TRPV4 and Calcium Oscillations in Tissue Repair

1 citations , January 2024 in “International journal of molecular sciences”

TRPV4 helps cells repair tissue and reduce scarring by controlling calcium levels.

research Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart

56 citations , October 2007 in “Journal of Biological Chemistry”

Cathepsin L is essential for heart health and its absence causes heart problems and hair loss.

research PD49-03 IS TADALAFIL ASSOCIATED WITH DECREASED RISK OF MAJOR ADVERSE CARDIAC EVENTS OR VENOUS THROMBOEMBOLISM IN MEN WITH LOWER URINARY TRACT SYMPTOMS?

April 2022

Tadalafil may reduce the risk of major heart events and blood clots in men with urinary symptoms.

research Anabolic-Androgenic Steroids and Cardiometabolic Derangements

2 citations , January 2021 in “Cureus”

Long-term anabolic steroid use can lead to heart and metabolic health issues.

research How Should You Use the Lab to Monitor Patients Taking a Mood Stabilizer

1 citations , July 2014 in “Current psychiatry”

Patients on mood stabilizers need regular health checks, but many aren't monitored properly.

research Antiandrogenic Therapy With Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction

56 citations , January 2015 in “Circulation”

Finasteride helps reduce heart issues and improves heart function.

research Male sex hormone and reduced plakoglobin jointly impair atrial conduction and cardiac sodium currents

June 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Male hormones and reduced plakoglobin can impair heart electrical function and increase arrhythmia risk in males.

research Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring

21 citations , July 2019 in “Cardiovascular Research”

High levels of male hormones in pregnant mice cause heart enlargement and poor heart function in their female babies.

research Inhibition of 5-Alpha Reductase Attenuates Cardiac Oxidative Damage in Obese and Aging Male Rats via the Enhancement of Antioxidants and the p53 Protein Suppression

September 2024 in “Chemico-Biological Interactions”

Finasteride improves heart function in obese and aging male rats by reducing oxidative stress and p53 protein levels.

Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

research Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart

44 citations , March 2015 in “PLOS ONE”

Fibroblast Growth Factor-9 (FGF-9) can help improve heart function in diabetic mice after a heart attack by reducing inflammation and harmful changes to the heart's structure.

Inconsistent Effects of Surgical and Chemical Castration on Arterial Baroreceptor Dysfunction and Cardiac and Brainstem Inflammation in Endotoxic Rats

research Inconsistent effects of surgical and chemical castration on arterial baroreceptor dysfunction and cardiac and brainstem inflammation in endotoxic rats

April 2020 in “The FASEB Journal”

Surgical and chemical castration have varied effects on heart and brain inflammation and artery function in sick rats.

research Exploring in vitro markers of potency of extracellular vesicles from cardiosphere-derived cells in the treatment of cardiac ageing

October 2022 in “European Heart Journal”

Potent extracellular vesicles from cardiosphere-derived cells can improve heart health and other functions in aging.

research Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

248 citations , November 2011 in “The EMBO Journal”

Wnt1/βcatenin signaling is crucial for heart repair after injury.

research Left Ventricular Function in Patients with Polycystic Ovary Syndrome: A Doppler Echocardiographic Study

13 citations , September 2008 in “Experimental and Clinical Endocrinology & Diabetes”

Young women with PCOS without additional risk factors may have normal heart function.

Cthrc1 Deficiency Aggravates Wound Healing and Promotes Cardiac Rupture After Myocardial Infarction via Non-Canonical WNT5A Signaling Pathway

research Cthrc1 deficiency aggravates wound healing and promotes cardiac rupture after myocardial infarction via non-canonical WNT5A signaling pathway

9 citations , January 2023 in “International Journal of Biological Sciences”

CTHRC1 is essential for healing and preventing heart rupture after a heart attack.

Maternal Androgen Excess Inhibits Fetal Cardiomyocyte Proliferation Through RB-Mediated Cell Cycle Arrest and Induces Cardiac Hypertrophy in Adulthood

research Maternal androgen excess inhibits fetal cardiomyocytes proliferation through RB-mediated cell cycle arrest and induces cardiac hypertrophy in adulthood

2 citations , August 2023 in “Journal of Endocrinological Investigation”

Excess maternal androgens can cause heart problems in offspring.