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GlossaryCardiotoxicity

damage to heart muscle from certain drugs or toxins

Cardiotoxicity refers to the damage that certain substances, such as chemotherapy drugs or toxins, can cause to the heart muscle. This damage can lead to a range of heart problems, including arrhythmias (irregular heartbeats), heart failure, and reduced heart function. For professionals, monitoring for cardiotoxicity is crucial when administering treatments known to have potential cardiac side effects, as early detection can help mitigate long-term damage.

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Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

research Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer

1461 citations , March 2004 in “Annals of oncology”

Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.

research Cardiac Morphologic Alterations in Acute Minoxidil Cardiotoxicity in Miniature Swine

27 citations , August 1984 in “Experimental and Molecular Pathology”

research Hypertrichosis Due to Minoxidil

45 citations , November 1979 in “British Journal of Dermatology”

Minoxidil causes excessive hair growth in almost all patients.

research Cardioprotective Effect of Royal Jelly on Paclitaxel-Induced Cardiotoxicity in Rats

24 citations , February 2016 in “PubMed”

Royal jelly can protect the heart from damage caused by paclitaxel.

research Thyroid Receptor Agonists for the Treatment of Androgenetic Alopecia

19 citations , October 2009 in “Bioorganic & Medicinal Chemistry Letters”

Thyroid receptor agonists may treat male pattern baldness without harmful side effects.

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community P-1075: a BETTER version of Minoxidil

in Research/Science 4 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community drinking topical minoxidil – extreme hair growth everywhere

in Minoxidil 396 upvotes 3 years ago

At this point. In this conversation, users discussed the risks of drinking topical minoxidil and suggested alternative treatments such as obtaining a prescription for oral minoxidil or finasteride.

community Please help! Continuously thinning while on Fin 1 mg

in Finasteride/Dutasteride 8 upvotes 4 days ago

The user is experiencing continued hair thinning despite taking Finasteride 1 mg daily for over a year and is hesitant to try Minoxidil due to potential side effects and inconsistency. Suggestions include trying topical Minoxidil once a day, considering oral Minoxidil, and possibly getting a skin biopsy to determine the type of hair loss.