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Spironolactone reduces the number of androgen receptor sites in rat skin by blocking them with its metabolite.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

Ganoderma lucidum may help treat prostate cancer by blocking male hormones and slowing cancer cell growth.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

Using two drugs together, Flutamide and 4-MA, is more effective for blocking male hormones than using each one alone.

Testosterone affects blood pressure control and inflammation in male rats with endotoxic shock, and blocking certain hormones may help treat it.

Testosterone changes reduce thyroxin levels in rats.

PF-05314882 selectively activates androgen receptors without much effect on prostate and may help in prostate cancer treatment and hair loss prevention.

17b-Estradiol in skin affects hair growth and tumor promotion.

Male pattern baldness is mainly caused by a hormone called dihydrotestosterone (DHT), and drugs that can block this hormone might help prevent hair loss.

Finasteride significantly reduced sperm production and caused testicular atrophy in hamsters.

Estradiol and castration reduced prostate cancer development in rats when applied at early stages, but were ineffective after cancer was established.

The dog's fertility was restored with antibiotics and finasteride treatment.

DHT is crucial for urethral formation, and its disruption can affect masculinization and lead to hypospadias.

Finasteride reduces prostate size and DHT in male mastomys but not in females.

Castration significantly reduces prostate size and BPH symptoms.

Prenatal antiandrogen treatment altered hormone levels in adult spotted hyenas, affecting males and females differently.

Surgical and chemical castration have varied effects on heart and brain inflammation and artery function in sick rats.

Blocking androgens at birth reduces sexual motivation in male rats.

Blocking a specific enzyme in male rat fetuses leads to the development of nipples and feminized genitalia.

Androgen, especially DHT, is crucial for erectile function in rats by affecting specific brain neurons.

5alpha-reductase 2 is crucial for proper male brain development and sexual differentiation.

Hypospadiac rats showed abnormal genital development, useful for studying human hypospadias.

5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.

Removing a testicular tumor in a dog reduced its aggressive behavior and skin problems.

Finasteride causes sperm production decrease in Mesocricetus auratus.