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Anti-Basal Cell Carcinoma Efficacy of a Topical Hedgehog Inhibitor Without Adverse Effects in Gorlin Syndrome Patients in a Phase 2 Randomized Controlled Trial

research 139 Anti-BCC efficacy of a topical hedgehog inhibitor without adverse effects in BCNS patients in a phase 2 randomized controlled trial

1 citations , April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical patidegib gel effectively treats basal cell carcinoma in Gorlin syndrome patients without causing the side effects seen with oral treatments.

research A Review of Coumarin Derivatives in Pharmacotherapy of Breast Cancer

431 citations , October 2008 in “Current Medicinal Chemistry”

Coumarin derivatives show promise as anti-estrogenic agents for treating breast cancer, with some in clinical trials.

research Ritlecitinib in Alopecia Areata: A 24‐Week Real‐World Experience Contrasting JAK Inhibitor‐Naïve and JAK Inhibitor‐Experienced Patients

December 2025 in “The Journal of Dermatology”

Ritlecitinib effectively reduces hair loss in JAK inhibitor-naïve alopecia areata patients.

research Understanding the formation mechanism of drug-polymer inclusion complex by structure elucidation and theoretical calculation

October 2023

The research found how certain drugs and polymers form stable complexes, which could help develop new pharmaceutical forms.

research Transcriptome-guided development of a fibrosis-reversal compound reduces skin scarring and allows regeneration via mitochondrial uncoupling

May 2026 in “Cell Reports Medicine”

FR-1 reduces skin scarring and promotes healing without harmful effects.

research Patent Evaluation: Hexahydrobenzo[f]quinolines as 5α-reductase inhibitors

June 1993 in “Current opinion in therapeutic patents”

Hexahydrobenzo[f]quinolines are effective at blocking the enzyme 5α-reductase.

research Baricitinib for alopecia areata

April 2023 in “Journal of Pakistan Medical Association”

Baricitinib is effective in promoting hair growth in severe alopecia areata.

research 061 Selective inhibition of tyrosine kinase 2 prevents and restores interleukin-12-induced hair follicle immune privilege collapse: a novel approach to alopecia areata therapy?

October 2021 in “Journal of Investigative Dermatology”

Blocking IL-12 can help treat alopecia areata by preventing hair follicle immune issues.

research Hormone Blocking Anticancer Drugs

March 2015

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.

Synthesis of Phenanthridin-3-One Derivatives: Non-Steroidal Inhibitors of Steroid 5-Alpha-Reductase

research Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

20 citations , June 1995 in “Tetrahedron Letters”

New chemicals were made that can block an enzyme linked to hair loss, prostate growth, and acne.

research Recent Advances in the Use of Cubosomes as Drug Carriers with Special Emphasis on Topical Applications

25 citations , January 2024 in “Journal of Lipids”

Cubosomes improve drug delivery for skin and eye diseases by enhancing adhesion, retention, and release.

research Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata

23 citations , October 2024 in “British Journal of Dermatology”

Ritlecitinib effectively treats alopecia areata and is safe for long-term use in people 12 and older.

research LB789 Novel IFNγ aptamer TAGX-0003 protected hair follicles from immune privilege collapse and reversed Alopecia Areata like phenotype in humanized mouse model

August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

TAGX-0003 protected hair follicles and reversed alopecia areata in a mouse model.

Imaging Prostate Cancer With Technetium-99m Tricarbonyl Finasteride Dithiocarbamate

research Imaging prostate cancer (PCa) with [^99m Tc(CO)₃ ]finasteride dithiocarbamate

4 citations , March 2018 in “Journal of labelled compounds & radiopharmaceuticals”

A new compound was effective for imaging prostate cancer in rats.

research 43018 Safety Analysis of Baricitinib in Adult Patients with Severe Alopecia Areata From 2 Randomized Clinical Trials over a Median of 1.6 years and up to 3.6 Years of Exposure

2 citations , September 2023 in “Journal of the American Academy of Dermatology”

Baricitinib is a safe and effective treatment for severe alopecia areata.

research Differential plasma proteome analysis reveals key proteins associated with insulin resistance in acne vulgaris patients

August 2025 in “Scientific Reports”

C4BPA protein may link acne severity and insulin resistance.

research Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects

25 citations , June 2017 in “Neuropharmacology”

Increasing TSPO in the brain reduces anxiety and depression.

research Potassium channel openers: pharmacological and clinical aspects

119 citations , October 1992 in “Fundamental & Clinical Pharmacology”

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

research Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

36 citations , March 2014 in “Annals of the Rheumatic Diseases”

Activating liver X receptors can reduce fibrosis by stopping certain immune cells from releasing harmful proteins.

research Insulin Resistance, Acanthosis Nigricans, and Polycystic Ovaries Associated with a Circulating Inhibitor of Postbinding Insulin Action

24 citations , May 1985 in “The Journal of Clinical Endocrinology & Metabolism”

A circulating inhibitor caused insulin resistance, but clomiphene improved symptoms.

research RU 58841, a new specific topical antiandrogen: A candidate of choice for the treatment of acne, androgenetic alopecia and hirsutism

49 citations , January 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

RU 58841 may treat acne, hair loss, and excessive hair growth.

research Synthesis and 5α-reductase inhibitory activity of 8-substituted benzo[ƒ]quinolinones derived from palladium mediated coupling reactions

14 citations , February 1998 in “Bioorganic & Medicinal Chemistry Letters”

Some newly made compounds can block an enzyme linked to hair loss and prostate growth, with one in particular being very selective.

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