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H3K9me3 Methyltransferase SETDB1 Controls Retrotransposon Silencing, DNA Methylation, Constitutive Heterochromatin Maintenance and 3D-Chromatin Structure in Epidermal Keratinocytes

research 766 H3K9me3 methyltransferase SETDB1 controls retrotransposon silencing, DNA methylation, constitutive heterochromatin maintenance and 3D-chromatin structure in epidermal keratinocytes

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

research Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

28 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

research Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11*1

1 citations , May 2004 in “Biochemical and Biophysical Research Communications”

Two new gene clusters important for hair formation were found on human chromosome 11.

research A Novel Type II Cytokeratin, mK6irs, is Expressed in the Huxley and Henle Layers of the Mouse Inner Root Sheath

45 citations , March 2001 in “Journal of Investigative Dermatology”

A new protein, mK6irs, is found in specific hair layers and may help understand hair growth and diseases.

research Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

37 citations , January 2006 in “Carcinogenesis”

Antizyme slows skin tumor growth by reducing cell growth in mice.

Regulatory Effect of Beta-Catenin on Proliferation of Hair Follicle Stem Cells Involves PI3K/Akt Pathway

research Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway

11 citations , March 2013 in “Journal of Applied Biomedicine”

β-catenin helps hair follicle stem cells grow by activating a specific cell pathway.

research Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11

27 citations , April 2004 in “Biochemical and Biophysical Research Communications”

Two new gene clusters important for hair formation were found on human chromosome 11.

Temporary Cell Cycle Arrest by ALRN-6924: A Novel P53-Targeting Strategy to Protect Human Scalp Hair Follicles Against Cyclophosphamide-Induced Alopecia

research 1409 Temporary cell cycle arrest by ALRN-6924: A novel, p53-targeting strategy to protect human scalp hair follicles against cyclophosphamide-induced alopecia

April 2023 in “Journal of Investigative Dermatology”

ALRN-6924 can protect hair follicles from chemotherapy damage by temporarily stopping cell division.

research Sgk3 links growth factor signaling to maintenance of progenitor cells in the hair follicle

53 citations , August 2005 in “The Journal of Cell Biology”

Sgk3 is essential for normal hair follicle growth and maintenance.

research Connexin 26 (GJB2) mutations in keratitis–ichthyosis–deafness syndrome presenting with squamous cell carcinoma

11 citations , November 2011 in “The Journal of Dermatology”

Connexin-26 gene mutations may increase cancer risk in KID syndrome patients.

Characteristics of KRT80 and Its Roles in Neoplastic Diseases

research Characters of KRT80 and its roles in neoplasms diseases

2 citations , May 2023 in “Cancer medicine”

KRT80 may worsen cancer by increasing growth and spread, but its full effects on treatment and outcomes need more research.

research KRASG12D mutant cells are outcompeted by wild type neighbours in adult pancreas in an EPHA2-dependent manner

August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Normal cells outcompete and remove mutant cells in the pancreas with the help of the EphA2 receptor.

research A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3

34 citations , January 2004 in “Genomics”

A cluster of 21 keratin-associated protein genes important for hair growth was found on human chromosome 21.

research Understanding The Molecular Mechanisms Of Hair Follicle Stem Cell Quiescence And Genome Plasticity

August 2013 in “eCommons (Cornell University)”

Runx1 and CDK inhibitors help keep hair follicle stem cells inactive, affecting their future roles.

research Keratin-6 driven ODC expression to hair follicle keratinocytes enhances stemness and tumorigenesis by negatively regulating Notch

8 citations , August 2014 in “Biochemical and Biophysical Research Communications”

ODC overexpression in hair cells increases tumor growth by reducing Notch signaling.

research K6/ODC transgenic mice as a sensitive model for carcinogen identification

57 citations , July 2000 in “Toxicology Letters”

K6/ODC transgenic mice are effective for quickly identifying cancer-causing chemicals.

Chromatin Architectural Protein CTCF Controls Epidermal Barrier Formation, Hair Follicle Fate Maintenance, and Suppresses Inflammatory Responses in the Skin Epithelium

research 874 Chromatin architectural protein CTCF controls epidermal barrier formation, hair follicle fate maintenance and suppresses inflammatory responses in the skin epithelium

April 2017 in “Journal of Investigative Dermatology”

The protein CTCF is essential for skin development, maintaining hair follicles, and preventing inflammation.

research Planar Cell Polarity Cadherin Celsr1 Regulates Skin Hair Patterning in the Mouse

92 citations , April 2009 in “Journal of Investigative Dermatology”

The Celsr1 gene is crucial for normal hair patterning in mice.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.

research Expression patterns of programmed cell death 4 protein in normal human skin and some representative skin lesions

37 citations , February 2007 in “Experimental Dermatology”

Increasing PDCD4 protein may help prevent or treat some skin cancers.

research PRC 2 preserves intestinal progenitors and restricts secretory lineage commitment

75 citations , September 2016 in “EMBO journal”

PRC2 is essential for maintaining intestinal cell balance and aiding regeneration after damage.

research Morphologic and molecular characterization of two novel Krt71 (Krt2-6g) mutations: Krt71 rco12 and Krt71 rco13

51 citations , December 2006 in “Mammalian Genome”

research Activated Kras Alters Epidermal Homeostasis of Mouse Skin, Resulting in Redundant Skin and Defective Hair Cycling

29 citations , October 2010 in “Journal of Investigative Dermatology”

Activating Kras in mouse skin causes excess skin and hair loss.

research Dedicator of Cytokinesis 5 Regulates Keratinocyte Function and Promotes Diabetic Wound Healing

25 citations , February 2021 in “Diabetes”

Dock5 is important for skin healing and could help treat diabetic wounds.

Novel Adenosine Triphosphate-Binding Cassette, Subfamily A, Member 12 Mutations Associated with Congenital Ichthyosiform Erythroderma

research Novel adenosine triphosphate (ATP)-binding cassette, subfamily A, member 12 (ABCA12) mutations associated with congenital ichthyosiform erythroderma

11 citations , September 2011 in “British Journal of Dermatology”

New ABCA12 gene mutations were linked to a skin condition with scaling and hair loss, and a treatment helped with hair loss in a related case.

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