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GlossaryCell Aggregates

groups of cells that adhere together forming a mass

Cell aggregates, also known as cell clusters, are groups of cells that adhere to each other, forming a mass. These aggregates can occur naturally in the body, such as in the formation of tissues and organs, or can be created in a laboratory setting for research purposes. In the context of hair and alopecia, cell aggregates might be studied to understand how hair follicles develop and how they can be regenerated or repaired.

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The Enhancement of Dermal Papilla Cell Aggregation by Extracellular Matrix Proteins Through Effects on Cell–Substratum Adhesivity and Cell Motility

research The enhancement of dermal papilla cell aggregation by extracellular matrix proteins through effects on cell–substratum adhesivity and cell motility

44 citations , June 2009 in “Biomaterials”

Skin cell clumping for hair growth is improved by a protein called fibronectin, which helps cells stick and move better.

research Human iPS Cell-Derived Cell Aggregates Exhibited Dermal Papilla Cell Properties in in vitro Three-Dimensional Assemblage Mimicking Hair Follicle Structures

10 citations , August 2021 in “Frontiers in cell and developmental biology”

Scientists made structures that look like human hair follicles using stem cells, which could help grow hair without using actual human tissue.

research Rapid Formation of Cell Aggregates and Spheroids Induced by a “Smart” Boronic Acid Copolymer

26 citations , August 2016 in “ACS Applied Materials & Interfaces”

A boronic acid copolymer quickly forms cell clusters, useful for tissue and tumor modeling.

research Canine Adipose-Derived Stem Cell Aggregates as a Viable Substitute to Actual Canine Dermal Papillae

4 citations , May 2015 in “Macedonian Veterinary Review”

Canine stem cell aggregates can effectively replace natural dermal papillae for hair research.

research The effect of ovine secreted soluble factors on human dermal papilla cell aggregation

3 citations , January 2016 in “International Journal of Trichology”

Sheep-derived factors improve human hair cell clustering, which may help hair growth.

research Author response: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

1 citations , July 2018

Fgf20 helps form hair follicle structures by stopping cell division and increasing cell movement.

research Decision letter: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation

April 2018

Fgf20 is crucial for hair follicle formation by influencing cell movement and growth.

research Ultrastructural Resemblance of Basal Cell Epithelioma to Primary Epithelial Germ

47 citations , April 1978 in “Journal of Cutaneous Pathology”

Basal cell epithelioma resembles fetal hair follicles, not adult or fetal skin.

research Familial aggregation of alopecia areata

295 citations , May 2016 in “Journal of the American Academy of Dermatology”

Alopecia areata, a common autoimmune hair loss condition, often runs in families.

research Impact of substrate stiffness on dermal papilla aggregates in microgels

12 citations , January 2018 in “Biomaterials Science”

Softer hydrogel surfaces help maintain hair growth-related functions in skin cells.

research Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective

December 2023 in “Aggregate”

Scientists are using clumps of special stem cells to improve organ repair.

research Cell-repellent polyampholyte for conformal coating on microstructures

June 2022 in “Scientific Reports”

Prevelex, a polyampholyte, can create a cell-repellent coating on microdevices, which can be useful in biomedical applications like hair follicle regeneration.

research Knockout of p16INK4a promotes aggregative growth of dermal papilla cells

2 citations , October 2017 in “Revista Da Associacao Medica Brasileira”

Removing p16INK4a from skin cells can lead to faster and more clumped growth, which might help with hair growth.

research The in vitro properties of dermal papilla cell lines established from human hair follicles

106 citations , April 1986 in “British Journal of Dermatology”

Dermal papilla cells from human hair follicles form unique structures and don't live as long as other skin cells in lab conditions.

research Optimized Microwell Array Device for Preparation of Hair Follicle Germ-like Aggregates

January 2022 in “Institutional Repositories DataBase (IRDB)”

Pen-type microwells are best for forming hair follicle germ structures.

research Expansion Culture of Hair Follicle Stem Cells through Uniform Aggregation in Microwell Array Devices

1 citations , February 2023 in “ACS Biomaterials Science & Engineering”

The new microwell device helps grow more hair stem cells that can regenerate hair.

Molecular Functional Analyses Revealed Essential Roles of HSP90 and Lamin A/C in Growth, Migration, and Self-Aggregation of Dermal Papilla Cells

research Molecular functional analyses revealed essential roles of HSP90 and lamin A/C in growth, migration, and self-aggregation of dermal papilla cells

10 citations , May 2018 in “Cell death discovery”

HSP90 and lamin A/C are crucial for hair growth and could be targets for treating hair loss.

research Strategies to enhance epithelial–mesenchymal interactions for human hair follicle bioengineering

57 citations , February 2013 in “Journal of Dermatological Science”

Improving the environment and cell interactions is key for creating human hair in the lab.

research Dermal papilla cells and melanocytes response to physiological oxygen levels depends on their interactions

7 citations , June 2021 in “Cell Proliferation”

Low oxygen levels improve the function of hair and skin cells when they are in direct contact.

research Features of hemorheological disorders in patients with alopecia associated with coronavirus infection

June 2025 in “Голова и шея.”

COVID-19-related hair loss may be linked to blood flow disorders and inflammation.

Detecting the Mechanism Behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus Nippon) Dermal Papilla Cells to Three-Dimensional Pattern

research Detecting the Mechanism behind the Transition from Fixed Two-Dimensional Patterned Sika Deer (Cervus nippon) Dermal Papilla Cells to Three-Dimensional Pattern

2 citations , April 2021 in “International Journal of Molecular Sciences”

The study concluded that changing the culture conditions can cause sika deer skin cells to switch from a flat to a 3D pattern, which is important for creating hair follicles.

research Minoxidil-loaded hyaluronic acid dissolving microneedles to alleviate hair loss in an alopecia animal model

12 citations , February 2022 in “Acta Biomaterialia”

Minoxidil-loaded hyaluronic acid microneedles can effectively increase hair growth and could be a promising treatment for hair loss.

research A Facile Synthesis of Mollugin

13 citations , October 2007 in “Bulletin of the Korean Chemical Society”

Mollugin may help treat diseases and boost hair growth and anti-aging.

research Hypersensitivity Reactions to Anticoagulant Drugs

28 citations , September 2008 in “Current Pharmaceutical Design”

Allergic reactions to blood thinners are rare but can be serious, requiring careful management and alternative treatments.

research Wound Healing Mechanisms

October 1982 in “American Journal of Nursing”

Wound healing is a complex process involving different cells and stages, leading to scar tissue formation and strength increase over time.

research The mesenchymal component of hair follicle neogenesis: background, methods and molecular characterization

131 citations , July 2009 in “Experimental Dermatology”

The document concludes that specific cells are essential for hair growth and more research is needed to understand how to maintain their hair-inducing properties.

research Histopathologic features of alopecia areata incognito: a review of 46 cases

34 citations , February 2012 in “Journal of Cutaneous Pathology”

The research found specific signs to diagnose alopecia areata incognito and noted patients generally regrow hair after steroid treatment.

research Early leonine facies with alopecia in a young man

3 citations , April 2016 in “International Journal of Dermatology”

A young man was diagnosed with trichoepitheliomas, causing thick skin and hair loss.

Overactivated Sonic Hedgehog Signaling Aggravates Intrauterine Adhesion by Inhibiting Autophagy in Endometrial Stromal Cells

research Overactivated sonic hedgehog signaling aggravates intrauterine adhesion via inhibiting autophagy in endometrial stromal cells

52 citations , September 2020 in “Cell Death and Disease”

Overactive sonic hedgehog signaling worsens uterine scarring by reducing cell recycling.

Basement Membrane Components Define the Microenvironment of Aggregated Fibroblasts in the Skin and Support Their Aggregation In Vitro

research Basement membrane components define the microenvironment of aggregated fibroblasts in the skin and support their aggregation in vitro

September 2025 in “bioRxiv (Cold Spring Harbor Laboratory)”

Basement membrane supports fibroblast aggregation, aiding hair follicle development.