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GlossaryCellular Retinoic Acid-Binding Protein 2

protein that regulates retinoic acid's effects in cells

Cellular Retinoic Acid-Binding Protein 2 (CRABP2) is a protein that binds to retinoic acid, a derivative of vitamin A, and helps regulate its availability and activity within cells. This protein plays a crucial role in cell growth, differentiation, and apoptosis, making it important in processes like skin health and hair growth.

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research Immunolocalization of Enzymes, Binding Proteins, and Receptors Sufficient for Retinoic Acid Synthesis and Signaling During the Hair Cycle

48 citations , March 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Retinoic acid production and signaling in hair follicles are regulated by location and timing, affecting hair growth and cycling.

Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

research Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1

3 citations , July 2020 in “Frontiers in Cell and Developmental Biology”

Vitexin Compound 1 may help reduce skin aging caused by UVA light.

research Expression of retinoid nuclear receptor superfamily members in human hair follicles and its implication in hair growth.

34 citations , September 1997 in “Acta Dermato Venereologica”

RXR agonists may promote hair growth in humans.

research Effect of retinoids on follicular cells

15 citations , July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology”

Retinoids can change the hair growth cycle by extending the growth phase and shortening the rest phase.

research Regulation of human dermal papilla cell production of insulin-like growth factor binding protein-3 by retinoic acid, glucocorticoids, and insulin-like growth factor-1

37 citations , June 1996 in “Journal of cellular physiology”

Retinoic acid, glucocorticoids, and IGF1 increase IGFBP-3 production in human dermal papilla cells, affecting hair growth.

research Expression patterns of TRα and CRABPII genes in Chinese cashmere goat skin during prenatal development

August 2015 in “Han'gug dongmul jawon gwahag hoeji/Han-guk dongmul jawon gwahak hoeji/Journal of animal science and technology”

TRα and CRABPII genes change their activity levels during goat fetal skin development.

Increased Retinol-Binding Protein 4 and Anti-RBP4 Antibody in Alopecia Areata

research Increased retinol‐binding protein (RBP) 4 and anti‐RBP4 antibody in alopecia areata

6 citations , June 2011 in “British Journal of Dermatology”

People with alopecia areata have higher levels of RBP4 protein and antibodies against it.

research Endogenous retinoids in the hair follicle and sebaceous gland

50 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

research Dynamic regulation of retinoic acid-binding proteins in developing, adult and neoplastic skin reveals roles for β-catenin and Notch signalling

84 citations , September 2008 in “Developmental biology”

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

research Estrogen regulates the expression of retinoic acid synthesis enzymes and binding proteins in mouse skin

3 citations , August 2021 in “Nutrition research”

Estrogen affects how vitamin A is processed in mouse skin, which may impact acne treatment, hair growth, and skin defense.

research Endogenous Retinoids in the Pathogenesis of Alopecia Areata

54 citations , September 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

Vitamin A affects hair loss and immune response in alopecia areata.

research Hairless Modulates Ligand-Dependent Activation of the Vitamin D Receptor-Retinoid X Receptor Heterodimer

28 citations , January 2012 in “Biological & pharmaceutical bulletin”

Hairless protein can both repress and activate vitamin D receptor functions, affecting gene regulation.

research Oral retinoids-present status

108 citations , November 1980 in “British Journal of Dermatology”

Oral retinoids are effective for various skin conditions but have side effects and should not be used during pregnancy.

research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage

101 citations , December 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Scientists turned mouse stem cells into skin cells that can grow into skin layers and structures.

research Hairless: A nuclear receptor corepressor essential for skin function

January 2006 in “Advances in developmental biology”

The Hairless gene is crucial for healthy skin and hair growth.

research Promoting axonal regeneration through exosomes: An update of recent findings on exosomal PTEN and mTOR modifiers

14 citations , October 2018 in “Brain Research Bulletin”

Exosomes help nerve fibers grow by affecting specific cell signaling pathways.

research Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia

20 citations , July 2017 in “Scientific Reports”

A single amino acid change in the vitamin D receptor can disrupt its function and lead to hair loss.

research Anti-Acne Agents Attenuate FGFR2 Signal Transduction in Acne

65 citations , February 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

research S100A6 Protein—Expression and Function in Norm and Pathology

21 citations , January 2023 in “International Journal of Molecular Sciences”

S100A6 protein is linked to disease progression, especially in cancers.

research Combination of Transcriptomics and Proteomics Reveals Differentially Expressed Genes and Proteins in the Skin of EDAR Gene-Targeted and Wildtype Cashmere Goats

1 citations , April 2023 in “Animals”

Deleting the EDAR gene in Cashmere goats affects genes and proteins related to hair growth.

research Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages

6 citations , December 2022 in “Cell reports”

Eating a high-fat fish oil diet caused mice to lose hair due to a specific immune cell activity in the skin linked to a protein called E-FABP.

research Cutaneous Retinoic Acid Levels Determine Hair Follicle Development and Downgrowth

31 citations , September 2012 in “Journal of biological chemistry/The Journal of biological chemistry”

The right amount of retinoic acid is essential for normal hair growth and development.

research Dietary Vitamin A Dose Dependently Regulates BMP4 and WNT7A in Hair Follicles

April 2017 in “The FASEB Journal”

Eating more vitamin A changes hair growth-related proteins in mice, affecting hair cycle stages.

research Retinoic-Acid-Related Orphan Receptor Alpha Is Involved in the Regulation of the Cytoskeleton of Hair Follicle Stem Cells

June 2025 in “Biomolecules”

RORA affects hair follicle stem cells' structure and movement, potentially helping treat hair loss.

research The Retinoic-Acid-Related Orphan Receptor Alpha May Be Highly Involved in the Regulation of Seasonal Hair Molting

February 2025 in “International Journal of Molecular Sciences”

RORA plays a key role in controlling seasonal hair molting by affecting hair follicle cell activity.

research 1435 Dynamic morphogen-p63 chromatin interactions that guide epigenetic changes and p63 activity in surface ectoderm commitment

April 2018 in “Journal of Investigative Dermatology”

The study found that p63 needs signals from morphogens to help skin cells differentiate properly.

Differential Activity of 2-Methylene-19-Nor Vitamin D Analogs on Growth Factor Gene Expression in Rhino Mouse Skin and Comparison to All-Trans Retinoic Acid

research Differential activity of 2-methylene-19-nor vitamin D analogs on growth factor gene expression in rhino mouse skin and comparison to all-trans retinoic acid

2 citations , November 2017 in “PloS one”

Some vitamin D analogs can thicken skin and reduce pore size like a common acne treatment, with one analog also affecting skin growth factors.

research The Molecular Biology of the Vitamin D Receptor

22 citations , January 2010 in “Humana Press eBooks”

The vitamin D receptor can affect gene activity even without its usual hormone in hair and skin.

Dermal EZH2 Simultaneously Orchestrates Wnt/β-Catenin Signaling Dependent Dermal Differentiation and Retinoic Acid Signaling Dependent Epidermal Proliferation During Murine Skin Development

research Dermal EZH2 simultaneously orchestrates Wnt/β-catenin signaling dependent dermal differentiation and retinoic acid signaling dependent epidermal proliferation during murine skin development

November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

Ezh2 controls skin development by balancing signals for dermal and epidermal growth.

Retinoid-Mediated Stimulation of Steroid Sulfatase Activity in Myeloid Leukemic Cell Lines Requires RARα and RXR and Involves the Phosphoinositide 3-Kinase and ERK-MAP Kinase Pathways

research Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways

24 citations , September 2005 in “Journal of Cellular Biochemistry”

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.