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Finasteride modifies 5-alpha-reductases through a two-step process, affecting inhibitor potency and possibly causing side effects.

Cepharanthine may help treat COVID-19 by targeting similar pathways as other inflammatory diseases.

Phosphodiesterase inhibitors like tadalafil can reduce cell growth in BPH caused by CD8+ T cells in low androgen conditions.

The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.

CTHRC1 is essential for healing and preventing heart rupture after a heart attack.

Cuscuta reflexa extract may help treat benign prostatic hyperplasia by reducing inflammation and oxidative stress.

Ch55 may help reduce skin scarring and fibrosis.

Tolvaptan can slow kidney disease progression, but doesn't affect mortality or kidney failure.

Targeted protein degraders show promise in treating cancer but need to target more diverse proteins.

Finding functions for unknown GPCRs is hard but key for making new drugs.

Finasteride boosts morphine's pain relief, stops tolerance, and reduces withdrawal in rats.

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Combining ciprofloxacin with other treatments may improve its effectiveness against resistant bacteria.

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

Finasteride boosts morphine's pain relief and prevents tolerance and withdrawal in rats.

YWS1903 is safe for pregnant rats at moderate doses but causes fetal issues at high doses.

Cepharanthine may help treat COVID-19 by targeting multiple pathways.

Cabergoline helped a boy with Cushing disease get better after surgery and radiotherapy didn't work.

Too much AKR1C3 enzyme causes resistance to finasteride by increasing testosterone.

CB-03-01 is a promising skin cream for treating hormone-related skin problems without causing harmful body-wide effects.

New treatments targeting androgen receptors show promise for drug-resistant prostate cancer.

A specific genetic trait in tumor cells is linked to longer survival without disease in certain lymphoma patients.

Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.

CTCF protein is essential for skin and hair follicle development in mice.

CTHRC1 helps sweat glands recover by rebuilding nearby blood vessels.

Nano-PROTACs could improve drug targeting and delivery by using nanotechnology.

TRPV3 and TRPV6 channels change structure to regulate calcium and heat responses.

The new delivery system could improve pain and inflammation relief in gout.

MOTILIPERM may help treat male infertility by reducing stress in cells.

Early use of infliximab in severe pediatric Crohn's disease can lead to significant improvement and remission.