research Epidermal–dermal coupled spheroids are important for tissue pattern regeneration in reconstituted skin explant cultures
Skin spheroids with both outer and inner layers are key for regrowing skin patterns and hair.
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research Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells
Escin may help treat hair loss by boosting a specific cell growth pathway.
research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
research 1330 Flexible fate determination ensures robust differentiation in the skin hair follicle
Hair follicle stem cells can change their role to ensure proper hair development.
research Transient stimulation of TRPV4‐expressing keratinocytes promotes hair follicle regeneration in mice
Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.
research Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor–Null Mice
Lack of vitamin D receptor increases skin tumor risk by boosting hedgehog signaling.
research Hair Regenerative Mechanisms of Red Ginseng Oil and Its Major Components in the Testosterone-Induced Delay of Anagen Entry in C57BL/6 Mice
Red ginseng oil and its components help promote hair regrowth and could treat hair loss.
research New substrates for stem cell control
New materials help control stem cell growth and specialization for medical applications.
research A study on the conditioning effects of natural shampoos using the scanning electron microscope*
Natural shampoos made in the lab conditioned hair better than commercial ones with chemicals.
research Effects of flavonoid derivatives on human microvascular endothelial cells
Some flavonoids may help with hair growth by affecting blood vessel function in hair follicles.
research Progranulin, a secreted tumorigenesis and dementia-related factor, regulates mouse hair growth
Progranulin overexpression leads to shorter, thinner hair and increased cell death in mouse hair follicles.
research Combination of an engineered Lactococcus lactis expressing CXCL12 with light‐emitting diode yellow light as a treatment for scalded skin in mice
The combined treatment with engineered bacteria and yellow LED light improved wound healing in mice.
research Pathogenesis of Chemical Leukoderma and Chemical‐Induced Vitiligo
Chemical leukoderma is temporary, while chemical-induced vitiligo can be persistent and harder to treat.
research A Review on Nanoparticle Based Herbal Remedies for the Management of Alopecia
Nanoparticle-based herbal remedies could be promising for treating hair loss with fewer side effects and lower cost, but more research is needed.
research 1317 Nicotinic acid suppresses sebaceous lipid synthesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2)
Nicotinic acid reduces excessive oil production in skin cells by activating a specific receptor, which could help treat acne.
research 711 Small molecule wnt pathway inhibitor (SM04755) as a potential topical psoriasis treatment
SM04755 may be an effective topical treatment for psoriasis.
research 710 Use of mass spectrometry imaging and a full thickness 3D skin equivalent for evaluation of percutaneous absorption
The document concludes that various topical treatments show promise for skin conditions like atopic dermatitis, psoriasis, and hair loss.
research Stem Cells in the Skin
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
research Viewpoint 3
Oxidative stress plays a significant role in vitiligo, and both skin and non-skin cells may be involved.
research In This Issue
Alexander the Great's engineers built a causeway using a natural sand bridge, some tiger moths avoid bats by mimicking toxic relatives' sounds, early metabolism and RNA enzymes support the ancient RNA world theory, and vitamin D is crucial for hair growth and its absence can cause baldness.
research Stem cells and the skin
Stem cells can rejuvenate skin, restore hair, and aid in wound healing.
research Dermal T cell immunity and key regulatory signaling pathways: Implications in immune-mediated alopecia and hair regeneration
Understanding T cells and signaling pathways can lead to better treatments for hair loss.
research Mesenchyme governs hair follicle induction
The mesenchyme can start hair growth, but the exact signal that causes this is still unknown.
research Epidermal homeostasis: a balancing act of stem cells in the skin
Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
research Scratching the surface of skin development
The document concludes that skin stem cells are important for hair growth and wound healing, and could be used in regenerative medicine.
research Melatonin membrane receptors in peripheral tissues: Distribution and functions
Melatonin affects many body functions beyond sleep by interacting with specific receptors in various tissues.
research The Role of Stromal Stem Cells in Tissue Regeneration and Wound Repair
Stromal stem cells may help heal wounds by becoming structural cells or affecting the immune system, but more research is needed to understand how.
research Environmental Factors and Puberty Timing: Expert Panel Research Needs
Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.
research Noggin is required for induction of the hair follicle growth phase in postnatal skin
Noggin is necessary to start the hair growth phase in skin after birth.
research Hair follicle differentiation and regulation.
Hair follicle growth and development are controlled by specific genes and molecular signals.