research A Modeling Conundrum: Murine Models for Cutaneous Wound Healing
Current murine models need improvement for better human wound healing research translation.
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960-990 / 1000+ resultsresearch Epidermis reconstructed from the outer root sheath of human hair follicle on de-epidermized dermis. Effect of retinoic acid
research 1250 Development of an ex vivo human skin explant model to examine candidate gene functions in the hair follicle and epidermis
The model can effectively test gene functions and drug responses in human skin.
research Engineering Human Skin with Spatially Defined Hair Peg-Like Structures Using Self-Organizing Composite Organoids and Micropatterned Dermal Scaffolds
research 3D Printing of Skin Equivalents with Hair Follicle Structures and Epidermal‐Papillary‐Dermal Layers Using Gelatin/Hyaluronic Acid Hydrogels
Scientists created a 3D printed skin that includes hair and layers similar to real skin using a special gel.
research 447 Skin-Associated Cartilage Consists of Lipid-Filled Cells That Modify Hair Growth via BMP and WNT Signaling
research Epidermal structure created by canine hair follicle keratinocytes enriched with bulge cells in a three‐dimensional skin equivalent model in vitro: implications for regenerative therapy of canine epidermis
Keratinocytes from dog hair follicles can create a functional skin layer in a lab model, useful for dog skin therapy.
research Reconstructed human skin shows epidermal invagination towards integrated neopapillae indicating early hair follicle formation in vitro
The experiment showed that human skin grown in the lab started to form early hair structures when special cell clusters were added.
research Skin equivalent containing collagen-human hair keratin matrice for formation of neodermis
HHK can help restore skin structure.
research Expression of Type II Collagen at the Middle Stages of Chick Embryonic and Human Fetal Skin Development
research Reconstruction of Tissue Engineered Skin Substitute Containing Appendages Using Dermal Papillae Cells And Keratinocytes
Using dermal papillae cells and keratinocytes in skin substitutes speeds up healing and helps form hair follicles and glands.
research Establishment of an in vitro hairless guinea pig dermal model
Researchers developed a cost-effective, ethical skin model using hairless guinea pig cells for toxicology studies.
research CUBIC Protocol Visualizes Protein Expression at Single Cell Resolution in Whole Mount Skin Preparations
The CUBIC protocol allows detailed 3D visualization of proteins in mouse skin biopsies.
research Abstracts
The model helps improve medical devices by showing how skin deforms under pressure.
research Growth of human hair follicle keratinocytes in vitro
The model successfully grew and differentiated hair follicle cells in the lab.
research Regional Variations in the Histology of Porcine Skin
Porcine skin varies by region, affecting its use as a human skin model.
research Reconstructed Tissue-engineered Skin with ES Cell-derived Epidermal Stem Cells and Collagen Sponge
Engineered skin using stem cells and collagen sponge effectively healed and regenerated complex skin features in mice.
research Generation of Skin Organoids: Potential Opportunities and Challenges
Skin organoids from stem cells could better mimic real skin but face challenges.
research A new in vitro culture system to produce a fully differentiated epidermis from human hair follicle outer root sheath cells
Researchers developed a method to grow skin-like tissue from hair cells.
research Development of a nude mouse model to study human sebaceous gland physiology and pathophysiology.
The model using human skin on mice helps study human sebaceous glands.
research Skin toxicity determined in vitro by three-dimensional, native-state histoculture.
This model can replace animal testing for quick, cost-effective skin toxicity tests.
research A perfusable vascularized full-thickness skin model for potential topical and systemic applications
The study created a skin model with realistic blood vessels that improves skin grafts and testing for drug delivery.
research Skin Anatomy.
research Finding models for skin diseases: successes and failures
The document concludes that while finding animal models for the skin disease Hidradenitis suppurativa is challenging, certain mouse mutations may provide useful insights for research and drug testing.
research Novel Tissue Mechanics-Guided Cellular Flows Enable the Evolution of Feather Follicles
Cellular flows and tissue mechanics guide feather follicle formation in birds.
research Skin wound healing in humans and mice: Challenges in translational research
The document concludes that mouse models are helpful but have limitations for skin wound healing research, and suggests using larger animals and genetically modified mice for better human application.
research Towards developing an organotypic model for the preclinical study and manipulation of human hair matrix-dermal papilla interactions
The study created a new model to better understand human hair growth and health.
research Enhanced Differentiation Potential of Pigmented Human Epidermal Equivalents
PmtHEE is a better model for studying pigmented skin because it includes melanocytes and shows improved cell differentiation.
research A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders
The new model helps understand and develop treatments for genetic skin disorders like AEC.
research 0873 Modeling junctional epidermolysis bullosa using tissue-engineered skin substitutes
Tissue-engineered skin substitutes can model junctional epidermolysis bullosa and may help develop gene therapy.