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GlossaryChromosome 17

contains genes crucial for cell growth and DNA repair

Chromosome 17 is one of the 23 pairs of chromosomes in humans and contains approximately 83 million base pairs, which represent about 2.5% of the total DNA in cells. It is notable for housing several important genes, including those related to the production of proteins involved in cell growth, DNA repair, and the development of the nervous system. Mutations or alterations in genes on Chromosome 17 can lead to various medical conditions, such as certain types of cancer and neurological disorders.

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research Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21

January 1993

The trichohyalin gene is located at chromosomal region 1q21 with other skin-related protein genes.

research Human Trichohyalin Gene Is Clustered with the Genes for Other Epidermal Structural Proteins and Calcium-Binding Proteins at Chromosomal Locus 1q21

37 citations , January 1993 in “Journal of Investigative Dermatology”

research Common Variants in the Trichohyalin Gene Are Associated with Straight Hair in Europeans

234 citations , November 2009 in “American journal of human genetics”

Common variants in the Trichohyalin gene are linked to straight hair in Europeans.

research Potential Role of the Epidermal Differentiation Complex in the Pathogenesis of Psoriasis

12 citations , December 2022 in “Frontiers in Bioscience-Landmark”

The role of certain genes in skin cell development may be linked to psoriasis, but the connection is unclear.

research Isolation and Characterization of Human Repetin, a Member of the Fused Gene Family of the Epidermal Differentiation Complex

77 citations , April 2005 in “Journal of Investigative Dermatology”

Repetin is a protein involved in skin and hair development, binding calcium and compensating for other proteins when needed.

research Epidermal Differentiation Complex: A Review on Its Epigenetic Regulation and Potential Drug Targets.

39 citations , January 2016 in “PubMed”

Understanding how EDC genes are regulated can help develop better drugs for skin diseases.

Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert

research Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 2111In fond memory of Dr Peter Steinert.

62 citations , January 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

research Complex X chromosome rearrangement associated with multiorgan autoimmunity

8 citations , July 2015 in “Molecular cytogenetics”

A complex X chromosome rearrangement can increase the risk of multiple autoimmune diseases.

research Current Genetics in Hair Diseases

1 citations , February 2013 in “InTech eBooks”

Genetic mutations cause various hair diseases, and whole genome sequencing may reveal more about these conditions.

research Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata

143 citations , January 2007 in “The American Journal of Human Genetics”

Certain genes on chromosomes 6, 10, 16, and 18 may increase the risk of alopecia areata.

research Gene Expression of Mouse S100A3, a Cysteine-Rich Calcium-Binding Protein, in Developing Hair Follicle

40 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

S100A3 protein is crucial for hair shaft formation in mice.

research Molecular Genetic Characteristics of the Hoxc13 Gene and Association Analysis of Wool Traits

January 2024 in “International journal of molecular sciences”

Hoxc13 gene affects wool length in Gansu alpine fine-wool sheep.

research Mutations in the Keratin 85 (KRT85/hHb5) Gene Underlie Pure Hair and Nail Ectodermal Dysplasia

42 citations , October 2009 in “The journal of investigative dermatology/Journal of investigative dermatology”

Mutations in the KRT85 gene cause hair and nail problems.

research Significance of the S100A4 Protein in Psoriasis

45 citations , July 2009 in “Journal of Investigative Dermatology”

The S100A4 protein is more common in psoriatic skin and could be a target for treating psoriasis.

research Increased expression of psoriasin (S100A7) and interleukin 17 (IL-17) in lesional skin in lichen planopilaris

2 citations , January 2024 in “Advances in Dermatology and Allergology”

S100A7 and IL-17 may contribute to inflammation in lichen planopilaris.

2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases the Expression of Genes in the Human Epidermal Differentiation Complex and Accelerates Epidermal Barrier Formation

86 citations , August 2011 in “Toxicological sciences”

TCDD speeds up skin barrier formation by increasing certain gene expressions.

Loss-Of-Function Mutations of an Inhibitory Upstream ORF in the Human Hairless Transcript Cause Marie Unna Hereditary Hypotrichosis

research Loss-of-function mutations of an inhibitory upstream ORF in the human hairless transcript cause Marie Unna hereditary hypotrichosis

181 citations , January 2009 in “Nature Genetics”

Certain mutations in a hair growth-related gene cause a type of genetic hair loss.

research Oral Manifestations of Hematologic and Nutritional Diseases

50 citations , November 2010 in “Otolaryngologic Clinics of North America”

Recognizing oral symptoms can help diagnose and treat blood and nutritional diseases early.

research Microarray analysis of androgenetic and senescent alopecia: Comparison of gene expression shows two distinct profiles

27 citations , July 2013 in “Journal of Dermatological Science”

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

research Congenital hair loss disorders: Rare, but not too rare

41 citations , November 2011 in “The Journal of Dermatology”

Some hair loss disorders are caused by genetic mutations affecting hair growth.

research SOX11 and SOX4 drive the reactivation of an embryonic gene program during murine wound repair

87 citations , September 2019 in “Nature Communications”

SOX11 and SOX4 help skin cells act like embryonic cells to heal wounds in mice.

Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

research Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration

72 citations , June 2001 in “Journal of Investigative Dermatology”

S100A4 and S100A6 proteins may activate stem cells for hair follicle regeneration and could be potential targets for hair loss treatments.

Similar Response Patterns to Topical Minoxidil Foam 5% in Frontal and Vertex Scalp of Men with Androgenetic Alopecia: A Microarray Analysis

research Similar response patterns to topical minoxidil foam 5% in frontal and vertex scalp of men with androgenetic alopecia: a microarray analysis

19 citations , September 2014 in “British Journal of Dermatology”

Minoxidil foam 5% effectively treats hair loss in both frontal and vertex scalp regions.

Perspectives on Hair Evolution Based on Comparative Studies on Vertebrate Cornification

research Perspectives on Hair Evolution Based on Some Comparative Studies on Vertebrate Cornification

17 citations , June 2012 in “Journal of experimental zoology. Part B, Molecular and developmental evolution”

Hair in mammals likely evolved from glandular structures, not scales.

Fine Structure and Immunocytochemistry of Monotreme Hairs, with Emphasis on the Inner Root Sheath and Trichohyalin-Based Cornification During Hair Evolution

research Fine structure and immunocytochemistry of monotreme hairs, with emphasis on the inner root sheath and trichohyalin‐based cornification during hair evolution

15 citations , July 2004 in “Journal of morphology”

Monotreme hair structure and protein distribution are similar to other mammals, but their inner root sheath cornifies differently, suggesting a unique evolution from reptile skin.

research Filaggrin mutations as an archetype for understanding the pathophysiology of atopic dermatitis

3 citations , August 2014 in “Journal of The American Academy of Dermatology”

Filaggrin mutations are linked to atopic dermatitis and help explain how genetics and environment affect the disease.

research Formation of the cornified envelope

3 citations , September 2005 in “Experimental dermatology”

The cornified envelope is crucial for skin's barrier function and involves key proteins and genetic factors.

research Quoi de neuf en recherche dermatologique ?

2 citations , December 2011 in “Annales de Dermatologie et de Vénéréologie”

2011 dermatological research found new skin aging markers, hair loss causes, skin defense mechanisms, and potential for new treatments.

research A Functional Role of S100A4/Non-Muscle Myosin IIA Axis for Pro-Tumorigenic Vascular Functions in Glioblastoma

December 2021 in “Research Square (Research Square)”

S100A4 and NMIIA promote tumor growth in glioblastoma by enhancing blood vessel functions.

research Hair Disorders

November 2019 in “Harper's Textbook of Pediatric Dermatology”

Understanding normal hair growth and loss in children is key to diagnosing and treating hair disorders.