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GlossaryCollagen Type VII

protein crucial for anchoring skin layers together

Collagen Type VII is a specific type of collagen protein that plays a crucial role in anchoring the outer layer of the skin (epidermis) to the underlying layer (dermis). It forms structures known as anchoring fibrils, which are essential for maintaining skin integrity and preventing blistering. Defects in Collagen Type VII can lead to a genetic condition called dystrophic epidermolysis bullosa, characterized by fragile skin that easily blisters and tears.

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Alterations of Collagen Type 1, Skin Fibroblasts, and Macrophages in the Scalp Following the Treatment of 1550-nm Erbium Glass Fractional Laser for Androgenetic Alopecia

research Alterations of collagen type 1, skin fibroblasts, and macrophages in the scalp following the treatment of 1550‐nm erbium glass fractional laser for androgenetic alopecia

June 2021 in “Journal of Cosmetic Dermatology”

Laser treatment shows promise for hair growth, but needs further research.

research Expression of collagen type I, skin fibroblasts and macrophages after 1550 nm erbium glass fractional laser in androgenic alopecia

January 2020

The 1550 nm fractional Er:Glass laser improved hair regrowth in patients with androgenic alopecia, but didn't significantly change collagen type I, skin fibroblasts, or macrophages. More research is needed for optimal results.

research 583 Induction of type 17 collagen decreases ultraviolet b-induced cellular senescence in human htert/ker-ct keratinocytes

July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

Increasing type 17 collagen reduces aging signs in skin cells caused by UV light.

research Promoting effect of type 17 collagen production by chlorogenic acid using PLGA nanoparticles in the human epidermal keratinocyte cell

8 citations , February 2020 in “Journal of Drug Delivery Science and Technology”

Encapsulating chlorogenic acid in nanoparticles boosts type 17 collagen production, potentially aiding skin care.

research Borate-modified recombinant type XVII collagen microneedles loaded with IGF-1 for the treatment of androgenetic alopecia

May 2025 in “International Journal of Biological Macromolecules”

A new microneedle treatment shows promise for better hair regrowth in androgenetic alopecia.

research 115 Distributions of type XII and XIV collagens in adult skin and the anagen hair follicle

July 1995 in “Journal of Dermatological Science”

Effects of Collagen Type XVII Alpha 1 on Epidermal Stem Cells in Aging Skin and the MicroRNA Intervention Mechanism

research [Effects of collagen type ⅩⅦ α1 on epidermal stem cells in aging skin and the microRNA intervention mechanism].

September 2022 in “PubMed”

Collagen type XVII α1 decreases with age, leading to skin aging, but targeting microRNA-203b-3p may help maintain its levels and improve skin health.

research Atelocollagen Increases Collagen Synthesis by Promoting Glycine Transporter 1 in Aged Mouse Skin

1 citations , December 2025 in “International Journal of Molecular Sciences”

Atelocollagen boosts collagen production and improves skin elasticity in aged skin.

research 1396 Interferon-24 regulates the expression of MMP1 and dermal collagen of the skin

April 2023 in “Journal of Investigative Dermatology”

IL-24 contributes to skin aging by increasing collagen-degrading enzymes and decreasing collagen production when exposed to air pollution.

research 1375 Effects of a new recombinant human collagen on skin aging

April 2023 in “Journal of Investigative Dermatology”

The new recombinant human collagen can help slow skin aging and repair skin, while also controlling inflammation.

research Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways

July 2025 in “Cosmetics”

Recombinant type XVII collagen may help regrow hair by activating specific cell pathways.

research Expression of the Orphan Protein Plet-1 during Trichilemmal Differentiation of Anagen Hair Follicles

30 citations , February 2010 in “The journal of investigative dermatology/Journal of investigative dermatology”

Plet-1 protein helps hair follicle cells move and stick to tissues.

research Matrix Metalloproteinase-19 Expression in Normal and Diseased Skin: Dysregulation by Epidermal Proliferation

56 citations , November 2003 in “Journal of Investigative Dermatology”

MMP-19 may worsen skin diseases by affecting skin growth and inflammation.

research Electron microscope observations on the glassy layer of the hair follicle*1

24 citations , December 1957 in “Experimental Cell Research”

The glassy layer of hair follicles has different fibril sizes and arrangements in guinea pigs and young mice.

research Corneal epithelial‐like transdifferentiation of hair follicle stem cells is mediated by pax6 and β‐catenin/Lef‐1

20 citations , April 2009 in “Cell Biology International”

Hair follicle stem cells can become corneal-like cells with the help of pax6.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research Connective tissue sheath of hair follicle is a major source of dermal type I procollagen in human scalp

4 citations , September 2012 in “Journal of dermatological science”

The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.

research Polysulfonic acid mucopolysaccharide exerts anti scarring effect in rats through modulation of TGF β 1/Smad signaling pathway

1 citations , February 2023 in “Tropical Journal of Pharmaceutical Research”

Polysulfonic acid mucopolysaccharide can reduce skin scarring.

Essential Fatty Acid Deficiency in a Patient with Vascular Ehlers-Danlos Syndrome

research Essential Fatty Acid Deficiency (EFAD) in a Patient with Vascular Ehlers Danlos Syndrome (EDS-4) (P12-053-19)

1 citations , June 2019 in “Current developments in nutrition”

A patient with Ehlers-Danlos Syndrome improved after treatment for fat malabsorption and essential fatty acid deficiency.

research 1327 Effect of ginsenoside Rd on dermal epidermal junction in fibroblast

April 2018 in “Journal of Investigative Dermatology”

Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.

research Initial damage produced by a single 15-Gy x-ray irradiation to the rat calvaria skin

9 citations , June 2020 in “European Radiology Experimental”

15-Gy x-ray irradiation temporarily alters rat calvaria skin without causing significant inflammation or fibrosis.

research [Experimental study on vascular endothelial growth factor 165 gene-modified rat hair follicle stem cells mediated by lentiviral vector].

February 2014 in “PubMed”

Modified rat hair follicle stem cells can help create artificial hair follicles, blood vessels, and skin.

research Interleukin‐10 Derived Apoptotic Vesicles Enhance Scarless Skin Healing by Modulating Fibroblast Metabolism and Fibrosis Pathways

October 2025 in “Cell Proliferation”

IL10_ApoEVs improve skin healing and reduce scarring.

research 1348 Changes in the aging dermal hair follicle environment in female scalp

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Aging causes changes in scalp cells that can negatively affect hair health.

research Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition

3 citations , October 2021 in “PLoS ONE”

Piperonylic acid speeds up wound healing by reducing inflammation and boosting collagen.

research 130 Expression of nidogen1 in basal cell carcinoma

April 2018 in “Journal of Investigative Dermatology”

Higher levels of nidogen1 and type IV collagen are found in basal cell carcinoma compared to normal skin.

research 1456 Tensor effect of anigozanthos flavidus flower extract: Modulation of tenascin-X to regenerate the skin

April 2018 in “Journal of Investigative Dermatology”

Anigozanthos Flavidus flower extract helps regenerate skin and reduce wrinkles.

Comparison of Mitochondrial Transplantation Using a Stamp-Type Multineedle Injector and Platelet-Rich Plasma Therapy for Hair Aging in Naturally Aging Mice

research Comparison of mitochondrial transplantation by using a stamp-type multineedle injector and platelet-rich plasma therapy for hair aging in naturally aging mice

9 citations , July 2020 in “Biomedicine & Pharmacotherapy”

Mitochondrial therapy and platelet-rich plasma therapy both stimulated hair regrowth in aging mice, with mitochondrial therapy showing similar effectiveness to plasma therapy.

research Dynamics of procollagen type 1 N-terminal propeptide in postmenopausal osteoporosis during bisphosphonate therapy and transcranial electrical stimulation

May 2024 in “International journal of medicine and psychology.”

Transcranial electrical stimulation with bisphosphonates helps maintain bone collagen better than bisphosphonates alone.

research Understanding the Nano‐topography Changes and Cellular Influences Resulting from the Surface Adsorption of Human Hair Keratins

41 citations , May 2012 in “Advanced Healthcare Materials”

Human hair keratins improve cell adhesion and growth on culture surfaces.