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GlossaryCollagen Type VII

protein crucial for anchoring skin layers together

Collagen Type VII is a specific type of collagen protein that plays a crucial role in anchoring the outer layer of the skin (epidermis) to the underlying layer (dermis). It forms structures known as anchoring fibrils, which are essential for maintaining skin integrity and preventing blistering. Defects in Collagen Type VII can lead to a genetic condition called dystrophic epidermolysis bullosa, characterized by fragile skin that easily blisters and tears.

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research Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin. The Absence of Type VII Collagen is Associated with Gelatinase-A (MMP2) Activity

42 citations , February 2000 in “Journal of Investigative Dermatology”

Type VII collagen absence helps skin development by allowing tissue remodeling.

research 1327 Effect of ginsenoside Rd on dermal epidermal junction in fibroblast

April 2018 in “Journal of Investigative Dermatology”

Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.

research Characterization of the epidermal-dermal junction in hiPSC-derived skin organoids

14 citations , May 2022 in “Stem cell reports”

The study created hair-bearing skin models that lack a key protein for skin layer attachment, limiting their use for certain skin disease research.

research Basement membrane changes in lichen planopilaris

7 citations , June 2009 in “Journal of the European Academy of Dermatology and Venereology”

Basement membrane changes in lichen planopilaris cause scarring and permanent hair loss.

research 312 CRISPR/Cas9-based targeted genome editing for correction of recessive dystrophic epidermolysis bullosa using iPS cells

1 citations , September 2019 in “Journal of Investigative Dermatology”

The research showed that CRISPR/Cas9 can fix mutations causing a skin disease in stem cells, which then improved skin grafts in mice, but more work on safety and efficiency is needed.

research Immunofluorescence analysis of the basement membrane zone components in human anagen hair follicles

29 citations , July 2003 in “Experimental Dermatology”

The upper hair follicle is stable, while the lower part allows movement during hair growth.

research 688 Precise and efficient editing of the COL7A1 gene in RDEB derived iPSCs with CRISPR/Cas9 and prime editing

July 2024 in “Journal of Investigative Dermatology”

CRISPR/Cas9 and prime editing can potentially fix skin disorder genes safely and effectively.

research CRISPR/Cas9-mediated Generation ofCOL7A1-deficient Keratinocyte Model of Recessive Dystrophic Epidermolysis Bullosa

June 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Scientists created cell lines to study a genetic skin disorder using CRISPR technology.

Availability of mRNA from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa

research 302 Availability of mRNA Obtained from Peripheral Blood Mononuclear Cells for Mutational Analysis in Dystrophic Epidermolysis Bullosa

November 2022 in “Journal of Investigative Dermatology”

Scientists developed a new way to study mutations in a skin condition using blood cells, which may help diagnose and treat the disease.

Efficient Genome Editing Using CRISPR/Cas9 Ribonucleoprotein Approach in iPS Cells for Recessive Dystrophic Epidermolysis Bullosa

research 924 Efficient genome editing using CRISPR/Cas9 ribonucleoprotein approach in iPS cells for recessive dystrophic epidermolysis bullosa

April 2019 in “Journal of Investigative Dermatology”

Researchers fixed gene mutations causing a skin disease in stem cells, which then improved skin grafts in mice.

research The distributions of type IV collagen .ALPHA. chains in basement membranes of human epidermis and skin appendages

36 citations , January 2007 in “Archives of Histology and Cytology”

Type IV collagen chains vary in different parts of human skin, with specific patterns linked to melanocytes.

Transforming Growth Factor-β, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

research Transforming Growth Factor-??, Smad, and Collagen Expression Patterns in Fetal and Adult Keratinocytes

16 citations , February 2007 in “Plastic and Reconstructive Surgery”

Keratinocytes show more TGF-β system activity and collagen production as they age, which might affect wound scarring.

research Read-Through for Nonsense Mutations in Type XVII Collagen‒Deficient Junctional Epidermolysis Bullosa

5 citations , April 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

A new therapy for a skin blistering condition has not been developed yet.

research Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

Genes linked to fibrosis are more active in people with central centrifugal cicatricial alopecia.

research The Function and Structure of the Skin

4 citations , November 2014

The skin protects the body, regulates temperature, senses touch, and makes vitamin D.

Beta-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding

research β-Catenin–Dependent Wnt Signaling: A Pathway in Acute Cutaneous Wounding [RETRACTED]

13 citations , February 2018 in “Plastic and Reconstructive Surgery”

The study found that a specific signaling pathway helps skin wounds heal faster but may lead to larger scars.

research Skin Biology: Understanding Biological Targets for Improving Appearance

1 citations , January 2009 in “Elsevier eBooks”

The document concludes that a deeper understanding of skin aging and photodamage is needed to create better skin treatments.

research Editors' Picks

October 2013 in “Journal of Investigative Dermatology”

Collagen VII helps skin heal and stay strong, sirolimus may lower skin cancer risk in kidney transplant patients, high-molecular-mass hyaluronan helps naked mole rats resist cancer, dermal γδ T cells aid in hair growth in rodents, and overexpression of IL-33 in mouse skin causes itchiness, offering a model for studying allergic inflammation treatments.

research Pathophysiology of the burn scar

3 citations , January 2012 in “Elsevier eBooks”

Burn scars form abnormally due to changes in wound healing, and more research is needed to improve treatments.

research Using proteomics to compare the molecular structures of sulfide and permeate-depilated sheepskins

January 2024 in “Collagen and leather”

The conclusion is that using bovine milk permeate to remove wool from sheepskins is eco-friendly and results in smoother, higher quality leather compared to traditional sulfide methods.

Functionalized Biomatrix for Wound Healing and Cutaneous Regeneration: Future Impactful Medical Products in Clinical Translation and Precision Medicine

research Functionalised-biomatrix for wound healing and cutaneous regeneration: future impactful medical products in clinical translation and precision medicine

2 citations , May 2023 in “Frontiers in Bioengineering and Biotechnology”

The document concludes that more research is needed on making and understanding biomaterial scaffolds for wound healing.

research VIII International Conference "Interdisciplinary aspects of diseases of the skin and mucous membranes" 11-12th March 2022

January 2022 in “Dermatology Review”

Higher IL-31 levels are linked to worse itching in chronic kidney disease patients.

Five Diverse Skin Type Considerations and Applications for Nonsurgical Combinations

research 5 Diverse Skin Type Considerations and Applications for Nonsurgical Combinations

January 2018

Tailored nonsurgical cosmetic procedures are crucial for safely treating diverse skin types, especially skin of color.

Multi-View Light Sheet Fluorescence Microscopy for Imaging Cellular Self-Assembly in Spheroids of Human Hair Follicle Dermal Papilla Cells and Keratinocytes

research 812 Multi-view light sheet florescence microscopy (LSFM) for imaging cellular self-assembly in spheroids of human hair follicle dermal papilla cells and keratinocytes

June 2020 in “Journal of Investigative Dermatology”

The technique effectively shows how human skin and hair cells form into ball-like structures.