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Safety, Tolerability, and Pharmacokinetics of CG2001 in Chinese Adult Male Subjects With Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled, Single- and Multi-Dose, Phase 1 Clinical Study

research Safety, tolerability, and pharmacokinetics of CG2001 in Chinese adult male subjects with androgenetic alopecia: a randomized, double-blind, placebo-controlled, single- and multi-doses, phase 1 clinical study

January 2026

CG2001 is safe, well-tolerated, and a promising treatment for hair loss with fewer side effects.

research Adipose Mesenchymal Stem Cell‐Derived Exosomes Versus Platelet‐Rich Plasma Treatment for Photoaged Facial Skin: An Investigator‐Blinded, Split‐Face, Non‐Inferiority Trial

13 citations , May 2025 in “Journal of Cosmetic Dermatology”

Adipose mesenchymal stem cell-derived exosomes are as effective as platelet-rich plasma for improving photoaged skin and are a good option for those who prefer not to use needles.

research Evaluation of Serum Paraoxonase, Arylesterase, Prolidase Activities and Oxidative Stress in Patients with Alopecia Areata

16 citations , December 2018 in “Skin pharmacology and physiology”

People with Alopecia Areata have higher oxidative stress and different enzyme activities compared to healthy individuals.

A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

research A Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Effects of a Polyphenol-Rich Fruit Extract Combined with Biotin on Wrinkle Morphology, Skin Surface Roughness, and Hair Shedding

June 2026 in “Cosmetics”

The supplement may reduce hair shedding but needs more research for skin benefits.

research In-Depth Exploration of Chemical Constituents from Justicia procumbens L. Through UHPLC-Q-Exactive Orbitrap Mass Spectrometry

August 2025 in “Molecules”

132 compounds were found in Justicia procumbens L., including 77 new ones.

The Combination of Virgin Coconut Oil and Nigella Sativa Oil in Wound Healing: A Histochemical Study of Diabetic Wounds

research The combination of Virgin Coconut Oil (VCO) and Nigella sativa Oil (NSO) in wound healing: A histochemical study of diabetic wounds

July 2025 in “Journal of Research in Pharmacy”

Combining Virgin Coconut Oil and Nigella Sativa Oil speeds up healing in diabetic wounds.

research Cysteine Prevents the Reduction in Keratin Synthesis Induced by Iron Deficiency in Human Keratinocytes

40 citations , July 2015 in “Journal of Cellular Biochemistry”

Cysteine helps maintain keratin production in skin cells even when iron is low.

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

76 citations , February 2007 in “Cancer Research”

Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

research Transcriptome Profiling of Human Follicle Dermal Papilla Cells in response to Porphyra-334 Treatment by RNA-Seq

7 citations , January 2021 in “Evidence-based complementary and alternative medicine”

Porphyra-334 may help reduce wrinkles and promote hair growth.

research Formulation and Evaluation of Valproic Acid Microemulsions for Enhanced Transfollicular Delivery in Guinea Pig Skin

November 2024 in “Journal of Cosmetic Dermatology”

Valproic acid microemulsions improve skin delivery compared to regular solutions.

research Pharmacophore Modeling and Three Dimensional Database Searching for Drug Design Using Catalyst: Recent Advances

153 citations , November 2004 in “Current Medicinal Chemistry”

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

research Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial

2 citations , November 2025 in “Journal of the American Academy of Dermatology”

Deuruxolitinib effectively regrows hair in adults with alopecia areata and is well tolerated.

research 640 Exploring the synergic effects of a plant and a peptide on hair follicle pigmentation

July 2022 in “Journal of Investigative Dermatology”

The combination of a plant extract and a peptide can increase hair pigmentation and may reverse greying.

research Expression analysis of KAP9.2 and Hoxc13 genes during different cashmere growth stages by qRT-PCR method

9 citations , June 2014 in “Molecular biology reports”

KAP9.2 and Hoxc13 genes are important for cashmere growth and vary in activity during different stages.

research Latín cadurcum 'female genitals' and Hesychian Greek xá8veog `hog': is there any connection between the terms?

1 citations , January 2006 in “Maia-rivista Di Letterature Classiche”

Polygonum multiflorum is used for health benefits but may cause liver issues.

research Translation, cultural adaptation and validation of the Brazilian version of the Alopecia Areata Quality of Life Index (AA-QLI-BRA)

July 2025 in “Anais Brasileiros de Dermatologia”

The Brazilian version of the Alopecia Areata Quality of Life Index is reliable for assessing patients' quality of life.

research Caizhixuan hair tonic regulates both apoptosis and the PI3K/Akt pathway to treat androgenetic alopecia

February 2023 in “PLOS ONE”

Caizhixuan hair tonic helps treat hair loss by promoting hair growth and improving hair follicles.

research Mitochondrial Oxygen Consumption and Immunocytochemistry of Human Dental Pulp Stem Cell Following 808 nm PBM Therapy: A 3D Cell Culture Study

April 2025 in “Journal of Biophotonics”

PBM therapy improves mitochondrial function and promotes tissue regeneration in dental pulp stem cells.

Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program

research Integrated Safety Analysis of Ritlecitinib, an Oral JAK3/TEC Family Kinase Inhibitor, for the Treatment of Alopecia Areata from the ALLEGRO Clinical Trial Program

January 2024 in “American journal of clinical dermatology”

Ritlecitinib is safe and well-tolerated for treating alopecia areata in patients aged 12 and older.

research Evaluation of the efficacy and treatment-emergent adverse events of deuruxolitinib for moderate to severe alopecia areata: a dose-ranging meta-analysis of 1,372 randomized patients

2 citations , October 2025 in “Frontiers in Medicine”

Deuruxolitinib effectively improves hair regrowth in alopecia areata but requires monitoring for side effects.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research The selective androgen receptor modulator GTx‐024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double‐blind, placebo‐controlled phase II trial

306 citations , August 2011 in “Journal of cachexia, sarcopenia and muscle”

Enobosarm significantly increased muscle mass and improved physical function in elderly men and postmenopausal women without serious side effects.

research Effects of the Usage of l-Cysteine (l-Cys) on Human Health

75 citations , March 2018 in “Molecules/Molecules online/Molecules annual”

L-Cysteine may have health benefits, but its effectiveness is still debated due to limited clinical trial data.

research 1366 Interest of Panax Ginseng and Albizia Julibrissin extracts to prevent age-related hair density reduction

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

Ginseng and Albizia extracts may help prevent age-related hair thinning.

In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

research In Vivo Investigation in Pigs of Intestinal Absorption, Hepatobiliary Disposition, and Metabolism of the 5α-Reductase Inhibitor Finasteride and the Effects of Coadministered Ketoconazole

14 citations , February 2011 in “Drug Metabolism and Disposition”

Ketoconazole increases finasteride's effectiveness and lifespan in the body.

research Wiederbehaarung bei einem Patienten mit Alopecia universalis und Psoriasis vulgaris unter Deucravacitinib‐Therapie

February 2025 in “JDDG Journal der Deutschen Dermatologischen Gesellschaft”

Deucravacitinib helped a man regrow hair and improve psoriasis.

research Development and characterization of polydeoxyribonucleotide (PDRN) loaded chitosan polyplex: In vitro and in vivo evaluation of wound healing activity

September 2023 in “International journal of biological macromolecules”

The chitosan/PDRN polyplex improved wound healing in diabetic rats.

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