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Study on Toxicity of Hydrocortisone 17-Butyrate 21-Propionate: Subacute Toxicity in Dogs by Percutaneous Administration

research STUDIED ON TOXICITY OF HYDROCORTISONE 17-BUTYRATE 21-PROPIONATE : 6. Subacute Toxicity in Dogs by Percutaneous Adminisration

January 1981 in “The Journal of Toxicological Sciences”

Hydrocortisone 17-butyrate 21-propionate ointment caused reversible side effects like skin issues, weight gain, and organ changes in dogs.

research Human Hair Follicle Benzo[a]pyrene and Benzo[a]pyrene 7,8-diol Metabolism: Effect of Exposure to a Coal Tar-Containing Shampoo

66 citations , January 1987 in “Journal of Investigative Dermatology”

Coal tar shampoo increases enzyme activity in hair follicles, enhancing carcinogen binding to DNA.

Nanocarriers for Optimizing the Balance Between Interfollicular Permeation and Follicular Uptake of Topically Applied Clobetasol to Minimize Adverse Effects

research Nanocarriers for optimizing the balance between interfollicular permeation and follicular uptake of topically applied clobetasol to minimize adverse effects

69 citations , December 2015 in “Journal of Controlled Release”

Nanocapsules can improve clobetasol delivery to hair follicles, reducing side effects.

research Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model

1 citations , August 2020

Croton membranaceus root extract can change how drugs are processed in the body.

Structural Characterization of Cyclosporin A, C, and Microbial Bio-Transformed Cyclosporin A Analog AM6 Using HPLC–ESI–Ion Trap-Mass Spectrometry

research Structural characterization of cyclosporin A, C and microbial bio-transformed cyclosporin A analog AM6 using HPLC–ESI–ion trap-mass spectrometry

7 citations , February 2014 in “Talanta”

Researchers developed a method to identify and analyze cyclosporin compounds and their structures effectively.

research Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase

43 citations , August 2016 in “Scientific Reports”

Cinnamomi cortex may help treat prostate enlargement by reducing related proteins.

Benzo[c]quinolizin-3-ones Theoretical Investigation: SAR Analysis and Application to Untested Compounds

research Benzo[c]quinolizin-3-ones Theoretical Investigation: SAR Analysis and Application to Nontested Compounds

6 citations , August 2004 in “Journal of Chemical Information and Computer Sciences”

The research found a link between certain molecular features and the biological activity of BC3, which can help identify or create new active compounds.

Preliminary Pharmacokinetics and Metabolism of Novel Non-Steroidal Antiandrogens in the Rat: Relation of Their Systemic Activity to the Formation of a Common Metabolite

research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite

16 citations , October 1994 in “The Journal of Steroid Biochemistry and Molecular Biology”

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-methylpregna-4,6-diene-3,20-dione

2 citations , October 2001 in “Analytical Sciences”

A new compound that could treat various androgen-related conditions was created and analyzed.

research Bound on the Risk for M-SVMs

January 2002 in “HAL (Le Centre pour la Communication Scientifique Directe)”

The enzyme system in hair follicles is similar to the liver's and is inhibited by certain substances.

research Effects of halogenated analogues of cortisol and progesterone upon hair growth in castrated mice.

1 citations , January 1978 in “PubMed”

Certain chemical changes to cortisol and progesterone can increase or decrease their ability to inhibit hair growth.

research Florid Cushing's Syndrome and Hirsutism Induced by Desoximetasone

25 citations , January 1978 in “JAMA”

Topical corticosteroids can cause serious side effects like Cushing's syndrome and hirsutism.

research Determination of Oxymatrine in Human Plasma by HPLC-MS

January 2006

A method was created to measure oxymatrine in human blood.

research Hair Cortisol Measurements in the Evaluation of Cushing's Syndrome

May 2016 in “Endocrine Abstracts”

Proximal hair cortisol is a reliable tool for diagnosing Cushing's Syndrome.

Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism

research Liquid Chromatography-Mass Spectrometry-Based In Vitro Metabolic Profiling Reveals Altered Enzyme Expressions in Eicosanoid Metabolism

April 2016 in “Annals of laboratory medicine”

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

research Verstärkter Haarwuchs unter Langzeittokolyse mit Fenoterol** unter Berücksichtigung von Testosteron, Androstandiol, Cortisol und ACTH*

9 citations , November 1980 in “Geburtshilfe und Frauenheilkunde”

Fenoterol treatment causes increased hair growth due to higher metabolism in hair follicles, not hormones.

Pharmacokinetics and Bioconversion of Dehydroepiandrosterone After Dexamethasone Application in Women with Polycystic Ovary Syndrome

research Pharmacokinetics and Bioconversion of Dehydroepiandrosterone after Application of Dexamethasone in Women with Polycystic Ovary Syndrome

January 2004 in “Online Publication Service of Würzburg University (Würzburg University)”

Women with PCOS have higher 5alpha-reductase activity, affecting steroid levels.

research Crystal Structure and Synthesis of 17α-Acetoxy-4-bromopregn-4-ene-3,20-dione

August 2002 in “Analytical Sciences”

The document concludes that a compound with potential for treating prostate cancer and hair loss was successfully made and its detailed structure was confirmed.

research Calcipotriol/dithranol

March 2019 in “Reactions Weekly”

research Preformulation studies of finasteride to design matrix systems for topical delivery

14 citations , August 2018 in “Journal of Pharmaceutical and Biomedical Analysis”

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

research Role of GABA-active neurosteroids in the efficacy of metyrapone against cocaine addiction

15 citations , June 2014 in “Behavioural Brain Research”

Neurosteroids may help metyrapone reduce cocaine addiction.

research Biotransformation of tirilazad in human: 4. effect of finasteride on tirilazad clearance and reduced metabolite formation.

3 citations , November 1998 in “PubMed”

research Neurosteroids Involved in Regulating Inhibition in the Inferior Colliculus

19 citations , September 2006 in “Journal of Neurophysiology”

Neurosteroids help balance brain signals when certain inhibitions are reduced.

research Synthesis and Evaluation of 2‘-Substituted 4-(4‘-Carboxy- or 4‘-carboxymethylbenzylidene)-N-acylpiperidines: Highly Potent and in Vivo Active Steroid 5α-Reductase Type 2 Inhibitors

22 citations , June 2002 in “Journal of Medicinal Chemistry”

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

research Neurosteroidogenesis Is Required for the Physiological Response to Stress: Role of Neurosteroid-Sensitive GABA_AReceptors

248 citations , December 2011 in “Journal of Neuroscience”

Neurosteroids are crucial for stress response, and targeting specific receptors may help treat certain disorders.