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This study explores a novel silicate-based therapy for inflammatory dilated cardiomyopathy (iDCM), a severe condition resulting from myocarditis. Researchers developed composite microneedles and ion solutions using calcium silicate bioceramics to deliver SiO3 2− ions directly to myocardial tissue or through systemic circulation. These ions modulate the cell microenvironment by regulating CD4 + T/T helper 17 (T H 17) cells and their interactions with neutrophils and fibroblasts via the FOXO signaling pathway. The therapy inhibits the hyperdifferentiation of CD4 + T cells to T H 17 cells and the transformation of neutrophils and fibroblasts, disrupting the cycle of inflammation and fibrotic lesions in iDCM. This biomaterial-based strategy shows promise for treating iDCM.

Low-Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System With a Focus on Pericardial Effusions

research Low‐Dose Oral Minoxidil and Associated Adverse Events: Analyses of the FDA Adverse Event Reporting System (FAERS) With a Focus on Pericardial Effusions

September 2024 in “Journal of Cosmetic Dermatology”

Low-dose oral minoxidil can cause serious side effects like heart issues, so use the lowest effective dose.

research Evaluation of methotrexate-loaded surfactants, ceramides and cholesterol-based lamellar phases as a topical treatment for psoriasis

2 citations , February 2022 in “Journal of Pharmacy and Pharmacology”

Methotrexate-loaded formulations showed promise for psoriasis treatment but need careful evaluation.

research A review of the sources and pharmacological research of morroniside

13 citations , September 2024 in “Frontiers in Pharmacology”

Morroniside has many health benefits, including protection against diabetes complications, bone and brain diseases, heart and skin issues, and it supports hair growth and reduces inflammation.

research Infliximab as First‐Line Therapy in Severe Pediatric Crohn Disease

19 citations , September 2006 in “Journal of Pediatric Gastroenterology and Nutrition”

Early use of infliximab in severe pediatric Crohn's disease can lead to significant improvement and remission.

research Recalcitrant alopecia areata responsive to leflunomide and anthralin—Potentially undiscovered JAK/STAT inhibitors?

11 citations , October 2018 in “Pediatric dermatology”

Leflunomide and anthralin may effectively treat severe alopecia areata.

research Multifunctional Hydrogel with Dual Functions of ROS Scavenging and Responsive Antibiotic Release for Synergistic Oral Mucositis Treatment

February 2026 in “ACS Omega”

The hydrogel effectively treats oral mucositis by reducing oxidative damage and bacterial infection.

research Comparison of Efficacy of Topical Betamethasone Dipropionate and Topical Minoxidil in Patients With Alopecia Areata

March 2024 in “Curēus”

Betamethasone dipropionate lotion is more effective than minoxidil solution for treating Alopecia Areata.

research A systematic review of pulse steroid therapy for alopecia areata

50 citations , January 2016 in “Journal of the American Academy of Dermatology”

Pulse steroid therapy for alopecia areata shows a 43% complete response rate but has a high relapse rate, especially in children.

research An assessment of (1) cyproterone acetate and (2) ethinyl oestradiol and lynoestrenol (Minilyn) in the treatment of idiopathic hirsutism

8 citations , November 1978 in “British journal of dermatology/British journal of dermatology, Supplement”

Cyproterone acetate can effectively treat idiopathic hirsutism, but ethinyl oestradiol and lynoestrenol may not always reduce hair growth.

research TREATMENT FOR ULERYTHEMA OPHRYOGENES WITH HYDROCORTISONE OINTMENT

4 citations , April 1955 in “Archives of Dermatology”

Hydrocortisone ointment effectively improved eyebrow skin and hair in a 10-year-old.

research Determination of Exemestane in Human Plasma by LC-MS-MS

January 2007 in “Zhōnghuá yàoxué zázhì”

The method effectively showed that the two exemestane preparations are bioequivalent.

research Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers

32 citations , April 2016 in “Aaps Pharmscitech”

Nanostructured lipid carriers improve minoxidil delivery for hair loss treatment.

Major Improvement of Very Severe Alopecia Areata in Patients Treated With the Combination of Baricitinib and Low Doses of Corticosteroids: An Eight-Case Series

research Major improvement of very severe alopecia areata in patients treated with the combination of baricitinib and low doses of corticosteroids: an eight-case series

July 2023 in “Clinical and Experimental Dermatology”

Combining baricitinib with low-dose corticosteroids significantly improved severe hair loss in eight patients.

research Reticular Erythematous Mucinosis Syndrome

6 citations , June 1986 in “The Journal of Dermatology”

Reticular erythematous mucinosis syndrome can occur with minimal mucin deposition.

research A Permanent Hair Loss in a Patient with Hypersensitivity to Intralesional Triamcinolone Injection

2 citations , January 2019 in “Annals of dermatology/Annals of Dermatology”

A patient experienced permanent hair loss due to an allergic reaction to a corticosteroid injection.

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Efficacy of Rituximab in Successful Management of Refractory Juvenile Systemic Lupus Erythematosus Complicated with Macrophage Activation Syndrome: A Case Report with Literature Overview

May 2026 in “Indian Journal of Dermatology”

Rituximab effectively managed a difficult case of juvenile lupus with complications, reducing the need for steroids.

research ADVANCES IN PSORIASIS THERAPY

20 citations , January 2000 in “Dermatologic Clinics”

New psoriasis treatments are effective but come with side effects and risks.

research [Clinical findings with a low-dosed antiandrogene (cyproteronacetate) and aethinyloestradiol women with virilising symptoms (author's transl)].

3 citations , April 1977 in “PubMed”

The treatment improved acne, seborrhoea, and hirsutism, with some side effects like spotting and nervousness.

research Spironolacton in dermatologischen Behandlungen

17 citations , October 2013 in “Der Hautarzt”

Effect of Different Methods for Making Allergenic Extracts from House Dust Containing Mites on Their Potency Using Diephuis and Voorhorst Methods

research Pengaruh Perbedaan Metode Pembuatan Ekstrak Alergenik Dari Debu Rumah Yang Mengandung Tungau Terhadap Potensinya Yang Dibuat Dengan Metode Diephuis Dan Metode Voorhorst

March 1999

Further trials are needed to explore the efficacy of triamcinolone acetonide in dermatology.

research Safety and tolerability of low-dose oral minoxidil in adolescents: A retrospective review

2 citations , July 2022 in “Journal of the American Academy of Dermatology”

The safety and tolerability of low-dose oral minoxidil for treating hair loss in adolescents is not clearly determined.

research Systemic Treatments for Lichen Planopilaris and Frontal Fibrosing Alopecia: A Retrospective Study of 315 Patients

1 citations , April 2025 in “Acta Dermato Venereologica”

Methotrexate is best for lichen planopilaris, and retinoids are best for frontal fibrosing alopecia, but side effects are common.

research Fe de errores

January 2003 in “Piel”

The document corrects a mistake by stating that pimecrolimus, not tacrolimus, is the drug that concentrates in the skin.

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