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GlossaryCross-Linking

chemical bonds form between polymer chains, enhancing material properties

Cross-linking refers to the process where chemical bonds are formed between different polymer chains, creating a network-like structure. This can increase the strength, stability, and rigidity of materials. In biological contexts, cross-linking can affect the properties of proteins and other macromolecules, influencing their function and interactions.

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research The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

2 citations , January 1993

Trichohyalin is a versatile protein involved in hair and skin structure.

research Research of protein grafting and cross-linking technology on pilling resistance of rabbit hair fabric

January 2013 in “Shanghai Textile Science & Technology”

Milk protein treatment reduces pilling in rabbit hair fabric.

research Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins

13 citations , January 2018 in “Advances in experimental medicine and biology”

research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair

11 citations , September 1996 in “Journal of applied polymer science”

Potassium cyanide treatment changes hair's disulfide bonds, making it more elastic.

research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair

2 citations , September 1996 in “Journal of Applied Polymer Science”

Potassium cyanide changes hair's disulfide bonds to monosulfide, affecting high-sulfur proteins more.

Minoxidil Exerts Different Inhibitory Effects on Gene Expression of Lysyl Hydroxylase 1, 2, and 3: Implications for Collagen Cross-Linking and Treatment of Fibrosis

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

38 citations , June 2005 in “Matrix Biology”

Minoxidil affects collagen-related genes, potentially helping treat fibrosis.

Visible Light-Mediated Environmentally Friendly Green Chemistry for Hair Cross-Linking

research Visible Light-Mediated Environmentally Friendly and Universally Applicable Green Chemistry for Hair Cross-Linking

3 citations , June 2023 in “ACS sustainable chemistry & engineering”

The study found a green method for strengthening hair works on all hair colors and is eco-friendly.

research ControlledRelease of Minoxidil through Hydrogel Cross-Linkingto Treat Androgenetic Alopecia

June 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

A new hydrogel method improves minoxidil delivery for better hair growth.

research Novel Compounds for Hair Repair: Chemical Characterization and In Vitro Analysis of Thiol Cross-Linking Agents

April 2025 in “Pharmaceuticals”

APA is a promising new compound for repairing damaged hair, outperforming Olaplex® in strength and elasticity.

research Synergistic effect of carbodiimide and dehydrothermal crosslinking on acellular dermal matrix

61 citations , January 2013 in “International Journal of Biological Macromolecules”

Combining DHT and EDC improves the strength and stability of PADM scaffolds for tissue engineering.

research Green chemistry method for hair strengthening and setting using visible light-mediated protein crosslinking

4 citations , June 2022 in “Journal of cleaner production”

New eco-friendly method strengthens and sets hair using light and causes less damage.

research An injectable photo-crosslinking silk hydrogel system with biphasic release of BTXA and 5-Fu promotes scarless wound healing

January 2026 in “RSC Advances”

The hydrogel helps heal wounds without scars by releasing two drugs gradually.

research Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing

August 2024 in “Nature Communications”

Softer hydrogels help wounds heal better with less scarring.

research Enzymatic Crosslinking of Amino Acids Improves the Repair Effect of Keratin on Hair Fibre

May 2023 in “Polymers”

Using enzymes to link proteins makes hair repair treatments more effective and long-lasting.

research Biochemistry of Transglutaminases and Cross-Linking in the Skin

57 citations , July 1983 in “Journal of Investigative Dermatology”

research Trans glutaminase-mediated cross-linking in mammalian epidermis

44 citations , January 1984 in “Molecular and Cellular Biochemistry”

research Non-Covalent Cross-Linking Hydrogel: A New Method for Visceral Hemostasis

7 citations , May 2024 in “Gels”

The new collagen and tannic acid hydrogel effectively stops bleeding and aids tissue repair better than current options.

research Synthesis and cross-linking in the structure and growth of hair keratins

6 citations , October 1988 in “Clinics in Dermatology”

The molecular details of hair growth are not well understood.

research Transglutaminase-mediated cross-linking in mammalian epidermis

3 citations , January 1984

research A Novel Crosslinking Approach for Biomanufacturing of a Collagen‐Based Skin Dermal Template

December 2024 in “Macromolecular Bioscience”

The new collagen template speeds up production and supports skin healing without harmful reactions.

research Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes

44 citations , March 2019 in “Experimental Dermatology”

A wide range of proteins are integrated into the skin's protective layer.

research Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia

June 2025 in “ACS Biomaterials Science & Engineering”

A new method using hydrogels and microneedle patches improves minoxidil delivery for better hair growth.

research Epidermal and hair follicle transglutaminases and crosslinking in skin

1 citations , January 1984

research Protective and Restorative Effects of a Bio-Based Crosslinking Complex on Chemically Damaged Hair

December 2025 in “Cosmetics”

The bio-based complex effectively repairs and protects chemically damaged hair.

research Epidermal and hair follicle trans glutaminases and crosslinking in skin

54 citations , January 1984 in “Molecular and Cellular Biochemistry”

research Eco-engineered recombinant collagen III-PEG hydrogels with curcumin synergy for accelerated skin regeneration: A green crosslinking strategy in wound therapeutics

September 2025 in “International Journal of Biological Macromolecules”

The new hydrogel with curcumin speeds up wound healing safely and effectively.

research The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

161 citations , June 1993 in “Journal of Biological Chemistry”

Trichohyalin helps in hair and skin cell structure and function by binding calcium and linking proteins.

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Related Terms

Research

research The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

research Research of protein grafting and cross-linking technology on pilling resistance of rabbit hair fabric

research Crosslinking Between Trichocyte Keratins and Keratin Associated Proteins

research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair

research Crosslinking structure of keratin. V. Number and type of crosslinks in microstructures of untreated and potassium cyanide treated human hair

research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis

research Visible Light-Mediated Environmentally Friendly and Universally Applicable Green Chemistry for Hair Cross-Linking

research ControlledRelease of Minoxidil through Hydrogel Cross-Linkingto Treat Androgenetic Alopecia

research Novel Compounds for Hair Repair: Chemical Characterization and In Vitro Analysis of Thiol Cross-Linking Agents

research Synergistic effect of carbodiimide and dehydrothermal crosslinking on acellular dermal matrix

research Green chemistry method for hair strengthening and setting using visible light-mediated protein crosslinking

research An injectable photo-crosslinking silk hydrogel system with biphasic release of BTXA and 5-Fu promotes scarless wound healing

research Hydrogel crosslinking modulates macrophages, fibroblasts, and their communication, during wound healing

research Enzymatic Crosslinking of Amino Acids Improves the Repair Effect of Keratin on Hair Fibre

research Biochemistry of Transglutaminases and Cross-Linking in the Skin

research Trans glutaminase-mediated cross-linking in mammalian epidermis

research Non-Covalent Cross-Linking Hydrogel: A New Method for Visceral Hemostasis

research Synthesis and cross-linking in the structure and growth of hair keratins

research Transglutaminase-mediated cross-linking in mammalian epidermis

research A Novel Crosslinking Approach for Biomanufacturing of a Collagen‐Based Skin Dermal Template

research Human stratum corneum proteomics reveals cross‐linking of a broad spectrum of proteins in cornified envelopes

research Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia

research Epidermal and hair follicle transglutaminases and crosslinking in skin

research Protective and Restorative Effects of a Bio-Based Crosslinking Complex on Chemically Damaged Hair

research Epidermal and hair follicle trans glutaminases and crosslinking in skin

research Eco-engineered recombinant collagen III-PEG hydrogels with curcumin synergy for accelerated skin regeneration: A green crosslinking strategy in wound therapeutics

research The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

research Cross-linked features of mouse pelage hair resistant to detergent extraction

research Cross‐linked features of mouse pelage hair resistant to detergent extraction

research Hair Follicle Transglutaminases and the Formation of ε-(γ-Glutamyl) Cross-links