research Editorial highlights
Recent advances show zebrafish can model anemia, Alx4 affects craniofacial and hair development, and mTORC1 is crucial for retinal development.
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research Selective Delivery of Tofacitinib Citrate to Hair Follicles Using Lipid-Coated Calcium Carbonate Nanocarrier Controls Chemotherapy-Induced Alopecia Areata
A new treatment using nanoparticles can effectively prevent and reduce hair loss caused by chemotherapy.
research Protein kinase C is a key target for attenuation of Leigh syndrome by rapamycin
Rapamycin may help treat Leigh syndrome by targeting protein kinase C.
research CD271 orchestrates skin structure, differentiation, and inflammation via PI3K/Akt and PKCα/ERK pathways
CD271 is crucial for maintaining healthy skin and preventing inflammation.
research New Design and preclinical evaluation of Non-Invasive Multi-Spot Positioning Transcutaneous On-Venous Laser System for Metabolic and Chronic Care Management
This study introduces a novel non-invasive laser system designed for personalized chronic care management, focusing on transcutaneous on-venous laser irradiation of blood (TOLIB) and laser-simulated moxibustion (LSM). The system features a low-power laser module (635 nm, 5-10 mW) to ensure safety and adaptability for extended use, addressing limitations of conventional devices. It offers precise dose control and personalization through a programmable interface, supporting applications like venous blood-cleansing and acupoint stimulation. The system's scalable design is suitable for diverse healthcare settings, including home care, and aims to enhance chronic disease management and metabolic health through synergistic therapeutic effects.
research Case Report: A Chinese Family of Woodhouse-Sakati Syndrome With Diabetes Mellitus, With a Novel Biallelic Deletion Mutation of the DCAF17 Gene
A new mutation in the DCAF17 gene was found in a Chinese family, causing Woodhouse-Sakati syndrome and diabetes.
research Cloning of a Functional Vitamin D Receptor from the Lamprey (Petromyzon marinus), an Ancient Vertebrate Lacking a Calcified Skeleton and Teeth
Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.
research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes
A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.
research 328 The transcription factor CEBPB is a novel hub gene and multi-functional disease driver in Psoriatic skin inflammation
ILC1-like cells can cause alopecia areata by themselves.
research Construction of Tissue-Engineered Nerve Conduits Seeded with Neurons Derived from Hair-Follicle Neural Crest Stem Cells
Neurons from hair follicles can help repair damaged nerves.
research Finasteride-associated central retinal vein occlusion
research Cystitis Due to Cytoxan: Case Report
A woman developed severe bladder inflammation after cancer treatment with Cytoxan.
research Claudin Expression Modulations Reflect an Injury Response in the Murine Epidermis
Claudin expression changes help the skin respond to injury.
research P62 Pre-clinical pharmacological and skin penetration profile of LDE255, a novel and specific Smoothened antagonist
LDE225 is a promising skin-applied treatment for basal cell carcinoma with good skin penetration and effectiveness.
research Cell Membrane-Camouflaged Nanoparticles Mediated Nucleic Acids Delivery
Cell membrane-coated nanoparticles could improve gene therapy by enhancing delivery and targeting of nucleic acids.
research Трансплантация генетически модифицированных мононуклеарных клеток пуповиной крови человека и прямая генная терапия при регенерации кожных ран у крыс
Genetically modified cells improved skin wound healing in rats.
research 42863 The association of milia-like calcinosis cutis, alopecia totalis and hyperthyroidism linked with the novel mutation for RBM28
Children with alopecia areata, especially with Down syndrome or thyroid issues, should be screened for thyroid disease.
research CtBP1 Overexpression in Keratinocytes Perturbs Skin Homeostasis
Overexpressing CtBP1 in skin cells causes skin and hair problems.
research Computational metal-flavonoids complexes presentation of greenly synthesized silver nanoparticles combined flavonoids from Lens culinaris L. as anticancer agents using BcL-2 and IspC proteins
The study investigated the use of Lens culinaris L. total extract (LCTE) for synthesizing silver nanoparticles (LC-AgNPs) and evaluated their anticancer and antimicrobial properties. The LC-AgNPs, characterized as spherical with an average size of 19.22 nm, demonstrated potent cytotoxic activity against MCF-7, HCT-116, and HepG2 cancer cell lines, with IC50 values of 0.37, 0.35, and 0.1 µg/mL, respectively. They induced apoptosis and affected cell cycle phases differently across the cell lines. Additionally, LC-AgNPs showed strong antimicrobial activity against Klebsiella pneumoniae and Acinetobacter baumannii. Molecular docking identified Kaempferol-3-O-robinoside-7-O-rhamnoside and Quercetin-3-D-xyloside as key constituents inhibiting Bcl-2 and IspC cancer targets when combined with the nanoparticles.
research 1376 A multi-scale spatial atlas of human skin links cancer cell states to site of origin
The research shows that skin cancer likely originates from hair follicles and that certain cell populations expand to promote skin cancer growth.
research Single‐cell RNA sequencing highlights the role of proinflammatory fibroblasts, vascular endothelial cells, and immune cells in the keloid immune microenvironment
Proinflammatory fibroblasts and vascular endothelial cells are key in keloid development.
research 560 Isolation of an “early” transit amplifying keratinocyte population in interfollicular human epidermis: a role for CD271 receptor
Scientists found a new type of skin cell that could help with skin repair and these cells work better with a certain protein.
research Noggin overexpression inhibits eyelid opening by altering epidermal apoptosis and differentiation
Noggin overexpression delays eyelid opening by affecting cell death and skin cell development.
research Platelet Concentrates Preconditioning of Mesenchymal Stem Cells and Combined Therapies: Integrating Regenerative Strategies for Enhanced Clinical Applications
Combining platelet concentrates with stem cells improves regenerative therapies.
research Pharmacophore Modeling and Three Dimensional Database Searching for Drug Design Using Catalyst: Recent Advances
The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.
research Abstracts
Get head MRI for babies with achondroplasia early, use free immunoglobulin light chains to detect certain neurodevelopmental disorders, and video calls work for speech therapy in patients with facial anomalies.
research Targeting integrin pathways: mechanisms and advances in therapy
New therapies are being developed that target integrin pathways to treat various diseases.
research Cells to Surgery Quiz: December 2017
Mohs micrographic surgery is effective for treating basal cell carcinoma on the eyelid, while radiotherapy has higher recurrence rates, and topical vitamin D3 may reduce and delay BCC formation in mice.
research Transcriptome analysis reveals the genetic basis underlying the formation and seasonal changes of nuptial pads in Rana chensinensis
Nuptial pads in Chinese brown frogs change seasonally due to specific gene activity.
research Chemical profiling and quantitation of bioactive compounds in Platycladi Cacumen by UPLC-Q-TOF-MS/MS and UPLC-DAD
Researchers identified new compounds in Platycladi Cacumen and found variations in its flavonoid content, which could aid in its quality control.