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GlossaryCyclin D1

regulates cell cycle progression from G1 to S phase

Cyclin D1, also known as CCND1, is a protein that plays a crucial role in regulating the cell cycle, specifically the transition from the G1 phase to the S phase, where DNA replication occurs. It acts as a regulatory subunit for certain enzymes called cyclin-dependent kinases (CDKs), and its overexpression is often associated with various types of cancer, as it can lead to uncontrolled cell proliferation.

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research Epidermal Growth Factor Induces Proliferation of Hair Follicle-Derived Mesenchymal Stem Cells Through Epidermal Growth Factor Receptor-Mediated Activation of ERK and AKT Signaling Pathways Associated with Upregulation of Cyclin D1 and Downregulation of p16

83 citations , October 2016 in “Stem Cells and Development”

Epidermal growth factor helps hair stem cells grow by activating specific cell pathways.

research RhoA promotes epidermal stem cell proliferation via PKN1-cyclin D1 signaling

21 citations , February 2017 in “PLoS ONE”

RhoA helps skin stem cells grow, aiding wound healing.

research Does D matter? The role of vitamin D in hair disorders and hair follicle cycling

98 citations , February 2010 in “Dermatology Online Journal”

Vitamin D may help treat hair disorders.

research Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer

71 citations , October 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Vitamin D receptor helps prevent skin cancer and supports skin health.

research The Transient Role for Calcium and Vitamin D during the Developmental Hair Follicle Cycle

18 citations , March 2016 in “Journal of Investigative Dermatology”

Vitamin D and calcium are essential for normal hair growth.

research Assessment of the anti‐hair loss potential of Camellia japonica fruit shell extract in vitro

10 citations , November 2022 in “International Journal of Cosmetic Science”

Camellia japonica fruit shell extract may help reduce hair loss by promoting hair cell growth and reducing stress effects.

research Cinnamomum burmannii Leaves-Derived Carbon Dots Promote Angiogenesis and Stimulate Hair Follicle Regeneration by Reshaping the Microenvironment of Hair Follicles

February 2026 in “ACS Applied Materials & Interfaces”

Carbon dots from Cinnamomum burmannii leaves can promote hair growth and regeneration.

Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

research Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells

5 citations , January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

12-O-Tetradecanoylphorbol-13-Acetate Induces Apoptosis in Renal Epithelial Cells Through a Growth Signal Conflict Prevented by Activated Ras

research 12-O-Tetradecanoylphorbol-13-acetate Induces Apoptosis in Renal Epithelial Cells through a Growth Signal Conflict Which Is Prevented by Activated ras1

4 citations , January 2001 in “Archives of Biochemistry and Biophysics”

Activated ras can protect kidney cells from a certain substance that causes cell death.

research Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours

297 citations , January 2002 in “Development”

Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.

research Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression

176 citations , February 2006 in “Cancer Research”

Patched1 helps prevent tumors by controlling cell growth.

research Deregulated expression of E2F1 induces hyperplasia and cooperates with ras in skin tumor development

136 citations , March 1998 in “Oncogene”

Overexpression of E2F1 can lead to skin tumors and disrupt hair growth.

research 1α,25(OH)2-Dihydroxyvitamin D3/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway

45 citations , September 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Vitamin D3 and its receptor help protect skin from UVB-related cancer.

Combination of Herbal Extracts and Platelet-Rich Plasma Induced Dermal Papilla Cell Proliferation: Involvement of ERK and Akt Pathways

research Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways

39 citations , June 2013 in “Journal of Cosmetic Dermatology”

Herbal extracts and platelet-rich plasma together may help increase hair growth by making certain cells grow more, through specific cell growth pathways.

research Induction of Hair Growth by Insulin-Like Growth Factor-1 in 1,763 MHz Radiofrequency-Irradiated Hair Follicle Cells

39 citations , December 2011 in “PLoS ONE”

Radiofrequency exposure can stimulate hair growth by increasing IGF-1 in hair follicle cells.

research Pre‐clinical evidences for the efficacy of tryptanthrin as a potent suppressor of skin cancer

36 citations , October 2019 in “Cell Proliferation”

Tryptanthrin effectively suppresses non-melanoma skin cancer and is safe for normal skin.

research A role of placental growth factor in hair growth

31 citations , February 2014 in “Journal of dermatological science”

Placental growth factor may help treat hair loss.

research Neural progenitor cell-derived nanovesicles promote hair follicle growth via miR-100

29 citations , January 2021 in “Journal of nanobiotechnology”

Tiny particles from brain cells help hair grow by targeting a specific hair growth pathway.

research Effects of glucocorticoid on human dermal papilla cells in vitro

27 citations , December 2012 in “The Journal of Steroid Biochemistry and Molecular Biology”

Dexamethasone may cause hair loss by stopping cell growth.

research Allopregnanolone promotes proliferation and differential gene expression in human glioblastoma cells

25 citations , January 2017 in “Steroids”

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

research Herbal Extracts Induce Dermal Papilla Cell Proliferation of Human Hair Follicles

24 citations , January 2015 in “Annals of Dermatology”

Herbal extracts may help hair grow and could be an alternative to synthetic hair loss treatments.

research Activin B Stimulates Mouse Vibrissae Growth and Regulates Cell Proliferation and Cell Cycle Progression of Hair Matrix Cells through ERK Signaling

23 citations , February 2019 in “International Journal of Molecular Sciences”

Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.

research Costunolide promotes the proliferation of human hair follicle dermal papilla cells and induces hair growth in C57BL/6 mice

21 citations , May 2018 in “Journal of Cosmetic Dermatology”

Costunolide helps human hair cells grow and can stimulate hair growth in mice.

Effects of Dihydrotestosterone on Rat Dermal Papilla Cells In Vitro

research Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways

14 citations , June 2018 in “Frontiers in pharmacology”

Green tea compound EGCG helps mink hair follicles grow by affecting certain cell growth pathways.

Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells In Vitro by Forming a Complex With Tcf4 and β-Catenin

research Twist1 Contributes to the Maintenance of Some Biological Properties of Dermal Papilla Cells in vitro by Forming a Complex With Tcf4 and β-Catenin

13 citations , August 2020 in “Frontiers in Cell and Developmental Biology”

Twist1 helps maintain important features of cells crucial for hair growth by working with Tcf4 and β-catenin.

Regulatory Effect of Beta-Catenin on Proliferation of Hair Follicle Stem Cells Involves PI3K/Akt Pathway

research Regulatory effect of β-catenin on proliferation of hair follicle stem cells involves PI3K/Akt pathway

11 citations , March 2013 in “Journal of Applied Biomedicine”

β-catenin helps hair follicle stem cells grow by activating a specific cell pathway.

research Cell Density-Dependent Upregulation of PDCD4 in Keratinocytes and Its Implications for Epidermal Homeostasis and Repair

10 citations , December 2015 in “International Journal of Molecular Sciences”

PDCD4 is important for controlling skin cell growth and healing.