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Therapeutic Targeting of Ocular Diseases with Emphasis on PI3K/Akt and OPRL Pathways by Hedera Helix L. Saponins: A New Approach for the Treatment of Pseudomonas Aeruginosa-Induced Bacterial Keratitis

research Therapeutic targeting of ocular diseases with emphasis on PI3K/Akt, and OPRL pathways by Hedera helix L. saponins: a new approach for the treatment of Pseudomonas aeruginosa-induced bacterial keratitis

1 citations , May 2025 in “Natural Products and Bioprospecting”

PEVIII is a promising treatment for Pseudomonas aeruginosa keratitis.

research Pathogenic variants affecting peptidyl arginine deiminase 3 and its major substrates underlie central centrifugal cicatricial alopecia

November 2025 in “Journal of Investigative Dermatology”

Genetic variants in specific genes cause central centrifugal cicatricial alopecia.

research Development and Validation of an HPLC-PDA Method for Quantitation of Ten Marker Compounds from Eclipta prostrata (L.) and Evaluation of Their Protein Tyrosine Phosphatase 1B, α-Glucosidase, and Acetylcholinesterase Inhibitory Activities

4 citations , December 2020 in “Natural Product Sciences”

The method identified and measured ten compounds from Eclipta prostrata, showing significant enzyme inhibitory effects.

research pH-Responsive Nanogels from Bioinspired Comb-like Polymers with Hydrophobic Grafts for Effective Oral Delivery

1 citations , October 2025 in “Gels”

Nanogels with hydrophobic modifications improve oral drug delivery for intestinal disease treatment.

research An in-depth study of DOPE:DOPC liposomes to maximize targeted drug delivery to cancer-associated cells

January 2023

DOPE:DOPC liposomes can improve targeted cancer drug delivery, reducing side effects and increasing effectiveness.

research Palmitoylethanolamide Stimulation Induces Allopregnanolone Synthesis in C6 Cells and Primary Astrocytes: Involvement of Peroxisome-Proliferator Activated Receptor-α

52 citations , May 2011 in “Journal of Neuroendocrinology”

PEA boosts allopregnanolone production and reduces oxidative stress in brain cells.

research Bioorthogonal Catalytic Microneedles Based on a Cytotoxic PEI Matrix for Synergistic Melanoma Therapy

April 2026 in “bioRxiv (Cold Spring Harbor Laboratory)”

A new microneedle patch significantly improves melanoma treatment by using a special material to activate cancer-fighting drugs and disrupt cancer cells.

research Evaluation of hydro-alcoholic extract of Eclipta alba for its anticancer potential: An in vitro study

50 citations , May 2011 in “Journal of Ethnopharmacology”

Eclipta alba extract shows potential as an anticancer agent by inhibiting cancer cell growth and promoting cell death.

research Advancing mitochondrial therapeutics: Synthesis and pharmacological evaluation of pyrazole-based inhibitors targeting the mitochondrial pyruvate carrier

4 citations , December 2024 in “European Journal of Medicinal Chemistry”

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

research Hollow polydopamine nanoparticles loading with peptide RL-QN15: a new pro-regenerative therapeutic agent for skin wounds

47 citations , October 2021 in “Journal of Nanobiotechnology”

HPDAlR nanoparticles greatly improve skin wound healing without toxicity.

research Carvone Decreases Melanin Content by Inhibiting Melanoma Cell Proliferation via the Cyclic Adenosine Monophosphate (cAMP) Pathway

12 citations , November 2020 in “Molecules”

Carvone helps treat skin issues by reducing melanin and stopping harmful cell growth.

research Nε-(carboxymethyl) lysine (CML) inhibits hair follicle formation by suppressing hair bulb condensation

November 2016 in “The Molecular Biology Society of Japan”

Preservation of Sebaceous Glands and Peroxisome Proliferator-Activated Receptor Gamma Expression in Central Centrifugal Cicatricial Alopecia

research Preservation of sebaceous glands and peroxisome proliferator-activated receptor gamma expression in central centrifugal cicatricial alopecia

1 citations , July 2018 in “Journal of The American Academy of Dermatology”

Sebaceous glands are often preserved and PPARy expression is constant in some cases of Central Centrifugal Cicatricial Alopecia.

research The peach RGF/GLV signalling peptide pCTG134 is involved in a regulatory circuit that sustains auxin and ethylene actions

May 2017 in “bioRxiv (Cold Spring Harbor Laboratory)”

The peach gene pCTG134 helps control the interaction between auxin and ethylene hormones during fruit ripening.

research Cytotoxic and antioxidant effect of the ethanolic extract of Citrullus colocynthis L. plant fruit

3 citations , May 2021 in “Genetics and Biodiversity Journal”

Citrullus colocynthis fruit extract has strong antioxidant and cancer-fighting potential.

Effect of N-Acetylcysteine on Hair Follicle Changes in Mouse Model of Cyclophosphamide-Induced Alopecia: Histological and Biochemical Study

research Effect of N-acetylcysteine on hair follicle changes in mouse model of cyclophosphamide-induced alopecia: histological and biochemical study

April 2024 in “Histochemistry and cell biology”

N-acetylcysteine may prevent hair loss caused by chemotherapy.

research 290 Brepocitinib improves cicatricial alopecia and downregulates key T-helper biomarkers

July 2024 in “Journal of Investigative Dermatology”

Brepocitinib improves cicatricial alopecia and reduces key immune markers.

research The anti-inflammatory and analgesic activities of 2Br-Crebanine and Stephanine from Stephania yunnanenses H. S.Lo

17 citations , January 2023 in “Frontiers in Pharmacology”

2Br-Crebanine and Stephanine reduce inflammation and pain effectively.

research Allopregnanolone (AP) induces opioid inhibition of hypothalamo-pituitary-adrenal (HPA) axis responses to interleukin-1β (IL-1β) in pregnancy

1 citations , October 2005 in “Experimental and Clinical Endocrinology & Diabetes”

Allopregnanolone and opioids together reduce stress hormone responses during pregnancy.

research Proteasome Inhibitors: An Expanding Army Attacking a Unique Target

474 citations , January 2012 in “Chemistry & biology”

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

research A machine learning and network framework to discover new indications for small molecules

8 citations , August 2020 in “PLOS Computational Biology”

A machine learning model called CATNIP can predict new uses for existing drugs, like using antidepressants for Parkinson's disease and a thyroid cancer drug for diabetes.

research Inhibitory effects of the ATP-sensitive potassium channel openers cromakalim, pinacidil and minoxidil on the carbachol–response curve in porcine detrusor muscle

3 citations , March 2012 in “Arab Journal of Urology”

Certain drugs can reduce bladder muscle contractions, potentially helping treat bladder diseases.

research Discovery and Optimization of Novel Pyridines as Highly Potent and Selective Glycogen Synthase Kinase 3 Inhibitors

October 2019

New pyridine compounds effectively inhibit GSK3, a diabetes treatment target.

research The concealed side of caspases: beyond a killer of cells

13 citations , December 2024 in “Cellular and Molecular Life Sciences”

Caspases do more than kill cells; they also help in cell growth and disease, and targeting them could lead to new treatments.

research Down-regulation of Melanocortin Receptor Signaling Mediated by the Amino Terminus of Agouti Protein in XenopusMelanophores

43 citations , May 1999 in “Journal of Biological Chemistry”

Agouti protein affects melanocortin receptors through competitive antagonism and receptor down-regulation.

research
Novel Clove Essential Oil Nanoemulgel Tailored by Taguchi’s Model and Scaffold-Based Nanofibers: Phytopharmaceuticals with Promising Potential as Cyclooxygenase-2 Inhibitors in External Inflammation

45 citations , March 2020 in “International Journal of Nanomedicine”

Clove essential oil nanoemulgel effectively reduces skin inflammation and is a promising alternative to traditional anti-inflammatory drugs.

research A machine learning and network framework to discover new indications for small molecules

August 2019 in “bioRxiv (Cold Spring Harbor Laboratory)”

The model successfully predicted new uses for existing drugs, like using certain hormonal and heart medications for respiratory and Parkinson's diseases, and a cancer drug for diabetes.

research Progesterone, neurosteroids, and the hormonal basis of catamenial epilepsy

30 citations , February 2003 in “Annals of Neurology”

Progesterone and related compounds may help control seizures linked to the menstrual cycle but have limitations that need addressing.

research Cepharanthine, a regulator of keap1-Nrf2, inhibits gastric cancer growth through oxidative stress and energy metabolism pathway

33 citations , December 2023 in “Cell Death Discovery”

Cepharanthine may help treat gastric cancer by causing cancer cell death and affecting energy use.

research NEW NON SYNTHETIC MOLECULES ARE ABLE TO INHIBIT APOPTOSIS IN DERMAL PAPILLAR CELLS OF HAIR BULB

January 2011 in “Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)”

New molecules can prevent cell death in hair follicles.

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