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The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Chromosomal differences affect how muscle cells respond to testosterone.

PFOS exposure disrupts hormone levels and enzyme activities in juvenile frogs, affecting males and females differently.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Modulating Cytochrome P450 activity could help develop new skin disease treatments.

Finasteride metabolites found in pigs match human studies, making pigs a valid model for human drug research.

Heart-specific steroid metabolism is crucial in cardiac hypertrophy.

A gene in Sebekia benihana, CYP-sb21, is needed for a specific reaction on the drug Cyclosporine A, which could be important for hair growth without affecting the immune system.

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

Genetic variants in CYP genes may worsen PCOS symptoms.

Glioblastoma cells can make androgens, which might help the tumor grow.

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

A genetic marker linked to a type of hair loss was found in most patients studied.

Scientists found a new gene in a bacterium that can modify an immunosuppressant drug, potentially helping to treat hair loss.

Steroid-producing capabilities in certain cancers may contribute to treatment resistance.

Exemestane is effective and safe for treating certain breast cancers, with mild side effects, but needs more research on long-term effects.

The traditional herbal formulas Yongdamsagan-Tang and Paljung-san, along with the drug finasteride, can reduce inflammation and may work together without affecting each other's effectiveness against benign prostatic hyperplasia.

Creating stronger blockers for skin enzymes might lead to better treatment for conditions like acne and excessive hair growth.

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

Certain drugs that block specific enzymes can help treat prostate diseases.

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

Enzymes are classified into six types and are essential for many biological processes, with only a few targeted by drugs.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

N-acetylcysteine may prevent hair loss caused by chemotherapy.

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

Dihydrotestosterone increases the activity of an enzyme in pubic skin cells that converts testosterone to dihydrotestosterone.

Adding soybean oil to Nonomuraea dietziae increases production of a beneficial compound by improving metabolism and enzyme systems.

The enzyme sEH is important for hair growth and its inhibition could help treat hair loss.

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.