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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Steroidal 5α-reductase and 17α-hydroxylase/17,20-lyase (CYP17) inhibitors useful in the treatment of prostatic diseases

51 citations , May 2013 in “The Journal of Steroid Biochemistry and Molecular Biology”

Certain drugs that block specific enzymes can help treat prostate diseases.

research Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review

49 citations , November 2019 in “Egyptian Journal of Medical Human Genetics”

Certain gene variants may contribute to high androgen levels in women with polycystic ovary syndrome.

research The Associations of Androgen-Related Genes CYP21A2 and CYP19A1 with Severe Acne Vulgaris in Patients from Southwest China

10 citations , March 2021 in “Clinical Cosmetic and Investigational Dermatology”

Certain gene variants are linked to severe acne, especially in males.

research THE GENETICS OF CYP GENE VARIANTS IN ASSOCIATION WITH POLYCYSTIC OVARY SYNDROME: A NARRATIVE REVIEW

December 2024 in “Era s journal of medical research”

Genetic variants in CYP genes may worsen PCOS symptoms.

research Genetic screening of non-classic CAH females with hyperandrogenemia identifies a novel CYP11B1 gene mutation

April 2016 in “Hormones”

A new mutation in the CYP11B1 gene was found in a woman with mild hyperandrogenemia, a rare cause of non-classic congenital adrenal hyperplasia.

research Association of Cyp11a Gene with Polycystic Ovarian Syndrome Patients in Lahore, Pakistan

January 2025 in “Pakistan Journal of Health Sciences”

The Cyp11a1 gene variation has a weak link to PCOS, but higher di-hydro-testosterone levels are found in PCOS patients.

research The significance of CYP11A1 expression in skin physiology and pathology

91 citations , March 2021 in “Molecular and Cellular Endocrinology”

CYP11A1 is crucial for skin health and disease by producing important steroids.

research Investigation of variants of the aromatase gene (CYP19A1) in female pattern hair loss

15 citations , June 2011 in “British Journal of Dermatology”

No link found between aromatase gene and female hair loss.

research Improved 2α-Hydroxylation Efficiency of Steroids by CYP154C2 Using Structure-Guided Rational Design

12 citations , February 2023 in “Applied and Environmental Microbiology”

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

Nongenomic Effects of 1α,25-Dihydroxyvitamin D3 on Cartilage Formation Deduced from Comparisons Between Cyp27b1 and Vdr Knockout Mice

research Nongenomic effects of 1α,25-dihydroxyvitamin D 3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice

11 citations , January 2017 in “Biochemical and biophysical research communications”

1α,25-dihydroxyvitamin D3 directly affects cartilage growth and development.

research Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population

7 citations , January 2015 in “Dermatology”

Two gene variations, rs6493497 and rs7176005, may be linked to female hair loss in Chinese people.

research Functional characterization and unraveling the structural determinants of novel steroid hydroxylase CYP154C7 from Streptomyces sp. PAMC26508

4 citations , October 2024 in “Heliyon”

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

Genotyping Of The Rs1800440 Polymorphism In CYP1B1 Gene And The Rs9258883 Polymorphism In HLA-B Gene In A Spanish Cohort Of 223 Patients With Frontal Fibrosing Alopecia

research Genotyping of the rs1800440 Polymorphism in CYP1B1 Gene and the rs9258883 Polymorphism in HLA-B Gene in a Spanish Cohort of 223 Patients with Frontal Fibrosing Alopecia

1 citations , September 2023 in “Acta dermato-venereologica”

Certain genetic variants are linked to frontal fibrosing alopecia in Spanish patients.

research Effect of a Benign Prostatic Hyperplasia (BPH) Xenobiotic - Croton membranaceus Müll.Arg. Root Extract on CYP1A2, CYP3A4, CYP2D6, and GSTM1 Drug Metabolizing Enzymes in Rat Model

1 citations , August 2020

Croton membranaceus root extract can change how drugs are processed in the body.

research MitoQ upregulates CYP19A1 to protect dermal papilla cells from DHT-induced mitochondrial dysfunction and apoptosis in androgenetic alopecia

January 2026 in “Biochemical Pharmacology”

MitoQ helps protect hair cells from damage in hair loss by boosting a protective enzyme.

research Coconut oil works as a gonadal feedback testosterone booster and increases pituitary aromatase (cyp19a1b) expression levels in fugu (Takifugu rubripes)

October 2025 in “Aquaculture”

Coconut oil boosts testosterone but doesn't fully trigger reproductive maturity in pufferfish.

research Exploring the role of CYP19A1 single nucleotide polymorphisms in the pathogenesis of female pattern hair loss

May 2025 in “Egyptian Journal of Dermatology and Venerology”

Certain gene changes and hormone levels are linked to female hair loss.

research MitoQ enhances CYP19A1 expression to stimulate WNT/β-catenin signaling pathway for promoting hair growth in androgenetic alopecia

November 2024 in “European Journal of Pharmacology”

MitoQ may help treat hair loss by boosting hair growth pathways.

research The role of CYP19A1 and ESR2 gene polymorphisms in female androgenetic alopecia in the Polish population

October 2021 in “Postepy Dermatologii I Alergologii”

No significant link was found between the studied genes and female hair loss in the Polish population.

research Pharmacophore Modeling and Three Dimensional Database Searching for Drug Design Using Catalyst: Recent Advances

153 citations , November 2004 in “Current Medicinal Chemistry”

The document concludes that Catalyst software is effective for drug design, identifying potent compounds for various medical conditions.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

research Gene variants associated with acne vulgaris presentation and severity: a systematic review and meta-analysis

47 citations , April 2021 in “BMC Medical Genomics”

Certain gene variants can influence acne risk and severity.

research In Search of New Therapeutics—Molecular Aspects of the PCOS Pathophysiology: Genetics, Hormones, Metabolism and Beyond

44 citations , September 2020 in “International Journal of Molecular Sciences”

New treatments are needed for PCOS that target its genetic, hormonal, and metabolic causes.

17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Reveal Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome

research 17-Hydroxyprogesterone Responses to Gonadotropin-Releasing Hormone Disclose Distinct Phenotypes of Functional Ovarian Hyperandrogenism and Polycystic Ovary Syndrome

42 citations , September 2007 in “The Journal of Clinical Endocrinology and Metabolism”

The research found that polycystic ovary syndrome (PCOS) has two distinct types, with one having more severe hormone and insulin issues.