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research Novel C-6 substituted and unsubstituted pregnane derivatives as 5α-reductase inhibitors and their effect on hamster flank organs diameter size

15 citations , May 2009 in “Steroids”

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.

research 51794 Compounded Solution to Personalize Alopecia Management

September 2024 in “Journal of the American Academy of Dermatology”

The compounded topical solution is safe, stable, and effective for personalized alopecia treatment.

New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects

research New 5?-reductase inhibitors: In vitro and in vivo effects

45 citations , February 2005 in “Steroids”

Four new compounds were more effective than finasteride in treating prostate issues and hair loss, with one being 100 times more active and safe for use.

research Phytochemicals With Anti 5-alpha-reductase Activity: A Prospective For Prostate Cancer Treatment

1 citations , March 2021 in “F1000Research”

Plant-based compounds might be effective, low-side-effect treatments for prostate cancer by blocking a specific enzyme.

research FINASTERIDE AND PSA

November 2005 in “The Journal of Urology”

research BindingDB Entry 50021519: Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment.

January 2025

research Novel 5α-Reductase Inhibitors: Synthesis, Structure−Activity Studies, and Pharmacokinetic Profile of Phenoxybenzoylphenyl Acetic Acids

18 citations , December 2005 in “Journal of Medicinal Chemistry”

A brominated phenoxy compound effectively inhibits a human enzyme and shows potential for clinical use.

Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens

research Synthesis and in Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-oxo-4-androstene-17.beta.-carboxamides as 5.alpha.-Reductase Inhibitors and Antiandrogens

12 citations , April 1995 in “Journal of Medicinal Chemistry”

The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

research Finasteride

June 2019 in “Reactions Weekly”

research Discovery of a novel hybrid from finasteride and epristeride as 5α-reductase inhibitor

18 citations , October 2010 in “Bioorganic & Medicinal Chemistry Letters”

New hybrid compound found to effectively prevent hair loss.

research New approach to 3-oxo-4-aza-5α-androst-1-ene-17β-(--butylcarboxamide)

14 citations , May 2005 in “Steroids”

A new method was developed to make finasteride for treating hair loss.

research Design, synthesis and biological evaluation of novel androst-3,5-diene-3-carboxylic acid derivatives as inhibitors of 5α-reductase type 1 and 2

8 citations , June 2017 in “Steroids”

New chemical compounds were made that effectively block an enzyme linked to prostate growth.

Expanding The Therapeutic Versatility Of Clascoterone

research Expanding the therapeutic versatility of clacosterone

October 2023 in “Journal of the American Academy of Dermatology”

Clascoterone cream could be used for other skin conditions affected by hormones.

Synthesis, Biological Evaluation, and Molecular Docking of 4-Amino-2H-benzo[h]chromen-2-one Analogs Containing the Piperazine Moiety

research Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety

7 citations , August 2019 in “Bioorganic & medicinal chemistry”

Analog 23 is a promising compound for prostate cancer treatment.

Imaging Prostate Cancer With Technetium-99m Tricarbonyl Finasteride Dithiocarbamate

research Imaging prostate cancer (PCa) with [^99m Tc(CO)₃ ]finasteride dithiocarbamate

4 citations , March 2018 in “Journal of labelled compounds & radiopharmaceuticals”

A new compound was effective for imaging prostate cancer in rats.

Synthesis and Biological Evaluation of Amino-Pyridines as Androgen Receptor Antagonists for Stimulating Hair Growth and Reducing Sebum Production

research Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production

17 citations , August 2007 in “Bioorganic & Medicinal Chemistry Letters”

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

research Estranys matins de febrer: Pauline Fondevila

January 2006 in “Benzina: Revista d'excepcions culturals”

Trienones are more effective at inhibiting the enzyme linked to hair loss than dienones.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Crystal structure of Steroid 5-alpha-reductase 2 in complex with Finasteride

April 2020

research Synthesis of 17β-N-arylcarbamoylandrost-4-en-3-one derivatives and their anti-proliferative effect on human androgen-sensitive LNCaP cell line

11 citations , June 2016 in “European Journal of Medicinal Chemistry”

Compounds 6f and 6g effectively stop prostate cancer cell growth without harming healthy cells.

research Caffeic acid N-[3,5-bis(trifluoromethyl)phenyl] amide as a non-steroidal inhibitor for steroid 5α-reductase type 1 using a human keratinocyte cell-based assay and molecular dynamics

December 2022 in “Scientific Reports”

Compound 4 is a promising treatment for hair loss with low toxicity.

research Cinnamomi Cortex (Cinnamomum verum) Suppresses Testosterone-induced Benign Prostatic Hyperplasia by Regulating 5α-reductase

43 citations , August 2016 in “Scientific Reports”

Cinnamomi cortex may help treat prostate enlargement by reducing related proteins.

research Testosterone replacement in the setting of Finasteride therapy: a therapeutic dilemma

1 citations , January 2010 in “Endocrine abstracts”

research Hormone Blocking Anticancer Drugs

March 2015

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.

research Alfuzosin/finasteride

May 2023 in “Reactions Weekly”

research Alfuzosin/finasteride

January 2013 in “Reactions Weekly”

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

research Development and evaluation of crystalline inclusion complex of finasteride using electrospraying as a novel approach

2 citations , July 2020 in “Journal of Drug Delivery Science and Technology”

Created finasteride complex to increase water solubility and drug release.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

research Identification of Potential Cytochrome p450c 17 Alpha Inhibitors for the Treatment of PCOS via Scaffold Hopping and Fragment-Based De-Novo Drug Design

February 2024

Potential new drugs for treating PCOS were identified.

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