research Reconsidering the Polycystic Ovary Syndrome (PCOS)
PCOS should be reclassified into two types based on hormone levels and symptoms.
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420-450 / 1000+ resultsresearch Hague (Hag): A New Mouse Hair Mutation With an Unstable Semidominant Allele
A new mouse hair mutation, called hague, is semidominant and unstable, but the exact cause is unknown.
research The Role of Thymosin Beta 4 on Odontogenic Differentiation in Human Dental Pulp Cells
Thymosin Beta 4 helps human dental pulp cells develop into tooth-forming cells, suggesting it could aid dental regeneration.
research The Catalog of Human Hair Keratins
Human hair keratins were cataloged, showing their roles in hair differentiation stages.
research STUB1 mutations in autosomal recessive ataxias – evidence for mutation-specific clinical heterogeneity
Different STUB1 gene mutations cause varied symptoms in autosomal recessive ataxias.
research Curcumin and cancer biology: Focusing regulatory effects in different signalling pathways
Curcumin may be an effective and safer anticancer agent by regulating key cell pathways.
research Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?
Some nutraceuticals may help in COVID-19 prevention and treatment, but more research is needed.
research [Genetic and biochemical aspects of keratin synthesis by hair follicles].
Coordinated gene activities are crucial for normal hair growth.
research Accumulations of Ca/P in the core of hairs from Taklamakan desert mummies
Mummy hair from the Taklamakan desert has calcium and phosphorus inside.
research Expression of novel keratin associated protein 5 genes in the cuticle layer of human hair follicles
The study found nine new hair protein genes in human hair follicles.
research Anti-inflammatory effects on murine macrophages of ethanol extracts of Lygodium japonicum spores via inhibition of NF-κB and p38
Lygodium japonicum spores can reduce inflammation by blocking certain cell signals.
research Genetic and biochemical aspects of the synthesis of keratin by hair follicles
Gene expression regulates keratin production for normal hair growth.
research Trichothiodystrophy: Current Concepts
TTD patients don't have a higher skin cancer risk because their main issue is with transcription, not DNA repair.
research Research Techniques Made Simple: Optical Clearing and Three-Dimensional Volumetric Imaging of Skin Biopsies
3D imaging of skin biopsies offers better accuracy but is time-consuming and can't clear melanin.
research Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking
Taohong Siwu Decoction may help treat hair loss by targeting multiple genes and pathways.
research Ex vivo SIM-AFM measurements reveal the spatial correlation of stiffness and molecular distributions in 3D living tissue
Collagen makes skin stiff, and preservation methods greatly increase tissue stiffness.
research Exploring the Complexities of TGF-beta Signaling in Keloids: Beyond the Classical Smad Pathway
The review delves into the complexities of TGF-β signaling in keloids, emphasizing the significance of both Smad-dependent and Smad-independent pathways. While the classical Smad pathway has been extensively studied, recent findings underscore the critical roles of alternative pathways like MAPK, PI3K/Akt, and others in keloid pathogenesis. These non-Smad pathways contribute to fibroblast proliferation, migration, and chronic inflammation, suggesting potential targets for more effective therapies. The document highlights the intricate crosstalk between these pathways and TGF-β signaling, which creates a self-sustaining fibrotic environment, making keloids resistant to treatment. It suggests that targeting these pathways could disrupt the fibrotic cascade and improve therapeutic outcomes, with precision therapies potentially reprogramming the fibrotic microenvironment to address high recurrence rates of traditional treatments.
research Dimensions of drug information
A new method organizes drug information to improve data use and create a comprehensive drug database.
research OXI1 kinase is necessary for oxidative burst-mediated signalling in Arabidopsis
OXI1 kinase is essential for plant defense and root hair growth in Arabidopsis.
research The JAK/STAT signaling pathway: from bench to clinic
The JAK/STAT pathway is important in cell processes and disease, and JAK inhibitors are promising for treating related conditions.
research Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn
Delta opioid receptors help regulate touch sensation by reducing neurotransmitter release in the spinal cord.
research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis
Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.
research Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression
Different signals work together to change gene activity and guide hair follicle stem cells to become specific cell types.
research The Role of Nutrition in Immune-Mediated, Inflammatory Skin Disease: A Narrative Review
Diet can influence inflammatory skin diseases.
research Keratin Expression Provides Novel Insight into the Morphogenesis and Function of the Companion Layer in Hair Follicles
Keratin patterns in hair follicles help understand hair growth and potential hair and nail disorders.
research Dissecting Hierarchies between Light, Sugar and Auxin Action Underpinning Root and Root Hair Growth
Light, sugar, and auxin together influence root and root hair growth in plants.
research Disentangling the Coronavirus Disease 2019 Health Disparities in African Americans: Biological, Environmental, and Social Factors
African Americans faced worse COVID-19 outcomes due to a mix of social, environmental, and biological factors.
research Harlequin ichthyosis (ichq): a juvenile lethal mouse mutation with ichthyosiform dermatitis.
The harlequin ichthyosis mouse mutation causes thick skin and early death, resembling a human skin disorder.
research Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages
Tmem50b and 2610305D13Rik genes play key roles in early mouse embryo development.
research Cooperation of TGF ‐β and FGF signalling pathways in skin development
TGF-β and FGF pathways are crucial for skin development and regeneration.