4 citations
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March 2020 in “JAAD Case Reports” Vitamin B12 deficiency can cause darkening of all nails.
September 1998 in “Journal of The European Academy of Dermatology and Venereology” Old people's nails often have problems due to body changes, more diseases, and self-care difficulties, affecting their movement and hand use.
8 citations
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May 2021 in “Journal of the European Academy of Dermatology and Venereology” A COVID-19 patient had unusual nail discoloration and nail separation possibly due to the virus's effects on small blood vessels.
September 2023 in “Cureus” Nails can reveal important health information about skin and body conditions.
January 2021 in “Skin Appendage Disorders”
Patients with graft-versus-host disease often have nail changes related to the nail matrix, with severity not linked to skin condition.
June 2025 in “British Journal of Dermatology” Consider amyloidosis in patients with specific nail changes and check for systemic issues.
January 2020 in “Medpulse International Journal of Medicine” Nail and hair changes are common in severe chronic kidney disease and should be treated to improve patients' quality of life.
10 citations
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August 2016 in “Anais brasileiros de dermatologia/Anais Brasileiros de Dermatologia” Vitiligo patients often have nail problems, so checking their nails is important.
February 2010 in “Journal of The American Academy of Dermatology” A woman's nail separation was likely caused by poor blood flow, and a treatment for similar conditions might help.
June 2025 in “British Journal of Dermatology” Nail abnormalities in children can indicate deeper health issues.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
1 citations
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January 2018 in “Journal of clinical & experimental dermatology research” Some nail changes in chilblains can look like lichen planus and may be severe and long-lasting.
3 citations
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August 2022 in “Cutis” Certain nail conditions can suggest thyroid problems, with different symptoms for underactive (slow, thin nails) and overactive (spoon-shaped, brittle nails) thyroid.
6 citations
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January 2017 in “International Journal of Dermoscopy” Dermoscopy is useful for early diagnosis and monitoring of nail diseases.
1 citations
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November 2025 in “Journal of Korean Medical Association” Recognizing nail changes helps diagnose and treat non-infectious skin diseases.
1 citations
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January 2013 in “Springer eBooks” The document concludes that skin and nail changes can indicate various underlying health conditions.
58 citations
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November 2004 in “The journal of investigative dermatology/Journal of investigative dermatology” The Foxn1 gene is essential for normal nail and hair development.
November 2022 in “Indian Journal of Dermatology/Indian journal of dermatology” Valproic acid can cause dark lines on nails.
January 2018 in “Elsevier eBooks” Different nail disorders are treated by targeting their specific causes and using appropriate medications or protective measures.
January 2026 in “Dermatology Practical & Conceptual” Nail changes are common in alopecia areata and can indicate its severity.
6 citations
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April 2024 in “Health Science Reports” Younger patients with severe alopecia areata often have nail problems.
11 citations
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November 2005 in “The Journal of Dermatology” A man's crushed thumb caused unusual horizontal nail ridges on all fingers of one hand.
13 citations
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April 2009 in “Journal der Deutschen Dermatologischen Gesellschaft” Nail disorders not caused by infection are common and can look similar, with psoriasis being the most frequent and having specific nail symptoms.
September 2021 in “CRC Press eBooks” Pregnancy can cause normal skin changes, including darkening of certain areas, nail changes, vascular changes, and breast changes like stretch marks.
18 citations
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March 1974 in “Acta dermato-venereologica” Chronic kidney disease can cause skin and nail problems.
June 1997 in “Australasian Journal of Dermatology” Researchers found new hair and nail genes, how hair reacts to UV, differences in white and pigmented hair growth, nerve changes in alopecia, treatments for baldness and alopecia, a toenail condition linked to a genetic disorder, and that nail fungus is more common in people with psoriasis.
45 citations
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January 2018 in “International Journal of Dermatology” Nail problems are common in people with alopecia areata, often leading to cosmetic and functional issues, but more research is needed for treatment guidelines.
September 2024 in “Cureus” A 10-year-old boy's nail condition is mainly cosmetic and improves over time with treatment.