The gene Endothelin 3 makes mice's fur darker by increasing pigment cells and pigment levels.
21 citations
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January 2008 in “Indian Journal of Dermatology Venereology and Leprology” 144 citations
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December 2017 in “Pigment cell & melanoma research” Melasma is now considered a skin aging disorder caused by sun exposure in people with a genetic tendency, which impacts treatment and prevention approaches.
Skin ages and changes due to sun, wind, and aging, causing dryness, thinning, and hair loss.
1 citations
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August 2018 in “Dermatologic Surgery” January 1999 in “Universitas Philosophica” Cornifin-alpha/SPRR1 is increased in certain skin conditions and by specific treatments.
2 citations
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March 2018 in “The Journal of Dermatology” The "color-transition sign" helps tell apart alopecia areata incognita from telogen effluvium by looking at hair color changes.
January 2004 in “Banca y finanzas: Revista profesional de gestión financiera” Androgens increase pigmentation in certain hamster skin areas, but estrogens can reverse this effect.
21 citations
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January 2023 in “Biomaterials Science” Microneedle patches with alpha-arbutin and resveratrol can effectively reduce skin pigmentation without irritation.
January 2010 in “Chinese Journal of Aesthetic Medicine” Melasma skin has more melanin and signs of aging, with strong CK10 expression linked to cell differentiation and aging.
2 citations
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May 2018 in “Dermatologic Surgery” 27 citations
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January 1995 Melanin in black hair protects it from sun damage better than light-brown hair.
6 citations
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September 2019 in “Journal of cosmetic dermatology” Lower melatonin levels are linked to more skin aging.
13 citations
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January 2001 in “Pediatric dermatology” A dark-haired Chinese girl had hair that looked banded under certain light but was normal under a microscope.
1 citations
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November 2024 in “Life” Desmodesmus pannonicus water extract may help reduce skin pigmentation, heal wounds, and promote hair growth.
9 citations
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July 2012 in “Dermatitis” Hair dye with para-phenylenediamine can cause skin depigmentation.
February 2026 in “Case Reports in Dermatology” Finasteride can cause melasma, especially in people with darker skin.
30 citations
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May 2019 in “Journal of the European Academy of Dermatology and Venereology”
19 citations
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July 2009 in “Clinical and Experimental Dermatology” The study found that long-term sun exposure does not significantly affect follicular plugs on the scalp, and the scalp's appearance is unique compared to other body parts.
21 citations
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November 2023 in “International Journal of Molecular Sciences” Melatonin helps reduce aging signs in human eyelid skin.
53 citations
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July 1981 in “Journal of Endocrinology” α-MSH and cyclic AMP boost melanin production, while cyclic GMP and melatonin reduce it.
8 citations
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May 2012 in “Clinical and Experimental Dermatology” An 82-year-old woman's hair turned white suddenly, likely due to a rare form of alopecia that targets pigmented hair.
13 citations
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January 2009 in “The Open Dermatology Journal” Oral pigmentation can be a sign of Addison's disease.
17 citations
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April 2004 in “Acta Clinica Belgica” UV light makes skin signs of lack of carotene and vitamin A more visible.
7 citations
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May 1988 in “International Journal of Dermatology” The patient's hair has unique structural differences with alternating bright and dark bands.
17 citations
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February 2015 in “Cell Death and Disease” Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.
31 citations
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November 2015 in “PloS one” Reducing Tyrosinase prevents mature color pigment cells from forming in mouse hair.
November 2022 in “Journal of Investigative Dermatology” Dynlt3 is important for melanosome transport and skin coloration.
13 citations
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March 2020 in “Frontiers in cell and developmental biology” A substance called TCQA could potentially darken hair by activating certain genes and increasing melanin.
March 2007 in “International Journal of Cosmetic Science” Hair with more melanin resists weather damage better.