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GlossaryDDB1 and CUL4 associated factor 17

protein involved in tagging unwanted proteins for degradation

DDB1 and CUL4 associated factor 17, also known as DCAF17, is a protein that plays a role in the regulation of cellular processes by participating in the ubiquitin-proteasome system, which tags unwanted proteins for degradation. Mutations in the DCAF17 gene have been linked to certain forms of alopecia, a condition characterized by hair loss, highlighting its importance in hair follicle biology and maintenance.

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The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome

research The Use of High-Density SNP Array to Map Homozygosity in Consanguineous Families to Efficiently Identify Candidate Genes: Application to Woodhouse-Sakati Syndrome

7 citations , January 2015 in “Case reports in genetics”

Using SNP array testing helped quickly find the gene causing Woodhouse-Sakati syndrome in two related individuals.

research To grow or not to grow: Hair morphogenesis and human genetic hair disorders

43 citations , December 2013 in “Seminars in Cell & Developmental Biology”

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.

Hair Growth-Promoting Effect of the Coffee Bean Residue Extract on Hair Follicle Dermal Papilla Cells via the Activation of Autophagy

research Hair Growth-Promoting effect of the coffee bean residue extract on hair follicle dermal papilla cells via the activation of autophagy

May 2024 in “Journal of functional foods”

Coffee bean residue extract helps hair growth by activating cell processes.

research Genomic prediction and genome-wide association studies of morphological traits and distraction index in Korean Sapsaree dogs

2 citations , November 2024 in “PLoS ONE”

Genomic prediction can improve breeding strategies for Korean Sapsaree dogs.

research Woodhouse-Sakati syndrome: genotype–phenotype review and case of intra-familial heterogeneity

July 2024 in “Journal of Rare Diseases”

Woodhouse-Sakati syndrome shows varied symptoms and genetic differences within families.

research Woodhouse-Sakati Syndrome Due to the Rare DCAF17 c.321+1G>A Mutation: The Second Case Report Worldwide

May 2026 in “Cureus”

A rare genetic mutation causes Woodhouse-Sakati syndrome symptoms.

research Writer’s Cramp Presentation of Woodhouse–Sakati Syndrome – “Out of the Woods”

1 citations , August 2021 in “Canadian journal of neurological sciences”

Woodhouse-Sakati syndrome can cause writer's cramp and other varied symptoms, highlighting the importance of genetic testing for diagnosis.

Case Report: A Chinese Family of Woodhouse-Sakati Syndrome With Diabetes Mellitus, With a Novel Biallelic Deletion Mutation of the DCAF17 Gene

research Case Report: A Chinese Family of Woodhouse-Sakati Syndrome With Diabetes Mellitus, With a Novel Biallelic Deletion Mutation of the DCAF17 Gene

3 citations , December 2021 in “Frontiers in endocrinology”

A new mutation in the DCAF17 gene was found in a Chinese family, causing Woodhouse-Sakati syndrome and diabetes.

Combinatorial Expression of Cell Cycle Regulators Is More Suitable for Immortalization Than Oncogenic Methods in Dermal Papilla Cells

research Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells

5 citations , January 2021 in “iScience”

Using a combination of specific cell cycle regulators is better for safely keeping hair root cells alive indefinitely compared to cancer-related methods.

research FOXP3 ⁺ regulatory T cells and age‐related diseases

26 citations , February 2021 in “FEBS Journal”

Targeting regulatory T cells may help treat age-related diseases.

research Case Report: A Deletion Variant in the DCAF17 Gene Underlying Woodhouse-Sakati Syndrome in a Chinese Consanguineous Family

1 citations , September 2021 in “Frontiers in genetics”

A genetic mutation in the DCAF17 gene caused Woodhouse-Sakati syndrome in a Chinese patient from a related family.

research Novel splicing‐site mutation in DCAF17 gene causing Woodhouse‐Sakati syndrome in a large consanguineous family

4 citations , December 2021 in “Journal of clinical laboratory analysis”

A new mutation in the DCAF17 gene was found to cause Woodhouse-Sakati syndrome in a large family.

research PROTACs: A novel strategy for cancer drug discovery and development

44 citations , May 2023 in “MedComm”

PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.

research Advancing Design Strategy of PROTACs for Cancer Therapy

4 citations , June 2025 in “MedComm”

PROTACs show promise for cancer treatment, but designing them effectively is challenging.

research Protein degradation: expanding the toolbox to restrain cancer drug resistance

7 citations , January 2023 in “Journal of Hematology & Oncology”

Using protein degradation to fight cancer drug resistance shows promise but needs more precise targeting and fewer side effects.

Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

research Folliculin, the Product of the Birt-Hogg-Dube Tumor Suppressor Gene, Interacts with the Adherens Junction Protein p0071 to Regulate Cell-Cell Adhesion

72 citations , November 2012 in “PloS one”

The protein folliculin, involved in a rare disease, works with another protein to control how cells stick together and their organization, and changes in this interaction can lead to disease symptoms.

research 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Affects Keratin 1 and Keratin 17 Gene Expression and Differentially Induces Keratinization in Hairless Mouse Skin

45 citations , March 1997 in “Journal of Investigative Dermatology”

research 415 IL-17C: Checkpoint in innate skin immunology

April 2018 in “Journal of Investigative Dermatology”

IL-17C is important in inflammatory skin diseases and could be a target for treatment.

research Keratin 17 modulates hair follicle cycling in a TNFα-dependent fashion

169 citations , May 2006 in “Genes & Development”

Keratin 17 is crucial for normal hair growth by regulating hair cycle transitions with TNFα.

research The transcriptional repressor CDP (Cutl1) is essential for epithelial cell differentiation of the lung and the hair follicle

165 citations , September 2001 in “Genes & development”

CDP is crucial for lung and hair follicle cell development.

research ADAM17 variant causes hair loss via ubiquitin ligase TRIM47 mediated degradation

May 2024 in “JCI insight”

A variant in the ADAM17 gene causes hair loss by increasing protein degradation through TRIM47.

research Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling

475 citations , October 2006 in “Proceedings of the National Academy of Sciences”

Folliculin helps regulate energy and nutrient sensing, impacting Birt–Hogg–Dubé syndrome.

research Keratin 17 Expression in the Hard Epithelial Context of the Hair and Nail, and its Relevance for the Pachyonychia Congenita Phenotype

88 citations , June 2000 in “Journal of Investigative Dermatology”

Keratin 17 is important for hair and nail structure and affects pachyonychia congenita symptoms.

CYLD Cutaneous Syndrome Tumors Demonstrate Increased NF-kB Signaling and Diminished Collagen Organization

research O19 CYLD cutaneous syndrome tumours demonstrate increased NF-κB signalling and diminished collagen organisation.

July 2023 in “British journal of dermatology/British journal of dermatology, Supplement”

Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.

research Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice

2 citations , June 2023 in “Journal of cell science”

Mutations in iRhom2 affect hair and skin in mice and are linked to esophageal cancer, with ADAM17 playing a crucial role.

Ubiquitomics of CYLD-Deficient Skin Tumors Reveals Dysregulation of Hair Follicle Keratinocyte Processes

research O02 Ubiquitomics of CYLD-deficient skin tumours reveals dysregulation of hair follicle keratinocyte processes

May 2024 in “British journal of dermatology/British journal of dermatology, Supplement”

CYLD deficiency in skin tumors disrupts hair follicle cell processes and protein secretion.

Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

research Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21

98 citations , June 2001 in “Journal of biological chemistry/The Journal of biological chemistry”

A cluster of sulfur-rich hair protein genes was found on chromosome 17.