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Discovery of (2S)-N-(6-Cyano-5-(Trifluoromethyl)Pyridin-3-Yl)-3-(6-(4-Cyanophenyl)-3,6-Diazabicyclo[3.1.1]Heptan-3-Yl)-2-Hydroxy-2-Methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

research Discovery of (2S)-N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment

December 2023 in “Journal of Medicinal Chemistry”

A new topical treatment for hair loss shows strong hair growth effects with low toxicity.

Effect of Different Methods for Making Allergenic Extracts from House Dust Containing Mites on Their Potency Using Diephuis and Voorhorst Methods

research Pengaruh Perbedaan Metode Pembuatan Ekstrak Alergenik Dari Debu Rumah Yang Mengandung Tungau Terhadap Potensinya Yang Dibuat Dengan Metode Diephuis Dan Metode Voorhorst

March 1999

Further trials are needed to explore the efficacy of triamcinolone acetonide in dermatology.

research Reduced metabolites mediate neuroprotective effects of progesterone in the adult rat hippocampus. The synthetic progestin medroxyprogesterone acetate (Provera) is not neuroprotective

123 citations , June 2006 in “Journal of Neurobiology”

Progesterone protects brain cells, but Provera does not.

High-Performance Liquid Chromatography–Diode Array and Electrospray-Mass Spectrometry Analysis of Non-Allowed Substances in Cosmetic Products for Preventing Hair Loss and Other Hormone-Dependent Skin Diseases

research High-performance liquid chromatography–diode array and electrospray-mass spectrometry analysis of non-allowed substances in cosmetic products for preventing hair loss and other hormone-dependent skin diseases

45 citations , June 2008 in “Journal of pharmaceutical and biomedical analysis”

The method effectively identifies banned substances in hair loss and skin disease cosmetics.

research Topical niacinamide 4% and desonide 0.05% for treatment of axillary hyperpigmentation: a randomized, double-blind, placebo-controlled study

40 citations , January 2013 in “Clinical Cosmetic and Investigational Dermatology”

Desonide is more effective than niacinamide for reducing underarm darkening.

Formulation and Evaluation of Triamcinolone Acetonide Serum with Derma Stamp Assisted Delivery for the Management of Alopecia Areata

research FORMULATION AND EVALUATION OF TRIAMCINOLONE ACETONIDE SERUM WITH DERMA STAMP ASSISTED DELIVERY FOR THE MANAGEMENT OF ALOPECIA AREATA

May 2026 in “Zenodo (CERN European Organization for Nuclear Research)”

The serum with microneedling effectively treats alopecia areata by enhancing drug delivery and is safe and patient-friendly.

research LC‐MS/MS‐based method for long‐term steroid profiling in human scalp hair

134 citations , March 2015 in “Clinical Endocrinology”

A new method accurately measures long-term steroid levels in human hair.

research Five‐year experience in the treatment of alopecia areata with DPC

37 citations , September 2009 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Diphencyprone (DPC) is an effective and safe long-term treatment for alopecia areata, especially with maintenance therapy.

research Dexpanthenol may be a novel treatment for male androgenetic alopecia: Analysis of nine cases

7 citations , April 2020 in “Dermatologic Therapy”

Dexpanthenol improves hair growth in male baldness.

research Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

Highly Efficient Nucleophilic Addition of Alkyl Grignard Reagents to 17-Ketosteroids in the Presence of Cerium(III) Chloride: Synthesis of 17α-Propyl-17β-Hydroxy-4-Androsten-3-One, an Androgen Receptor Antagonist

research Highly efficient nucleophilic addition of alkyl Grignard reagents to 17-ketosteroids in the presence of cerium(III) chloride: Synthesis of 17α-propyl-17β-hydroxy-4-androsten-3-one, an androgen receptor antagonist

14 citations , February 1994 in “Tetrahedron Letters”

Adding cerium(III) chloride to Grignard reagents improves the making of compounds that could treat prostate issues and hair loss.

research Computational Evaluation of Dibenzo Compounds as Potential Dual Inhibitors of Androgen Receptor and 5α-Reductase

January 2022 in “Asian journal of Current Research in Clinical Cancer”

Some dibenzo compounds might help treat cancer with fewer side effects.

research Effect of Carbamates on mRNA Encoding Lipid Enzymes in Hamster Flank Organs

1 citations , February 2014 in “Archiv Der Pharmazie”

Carbamates may help treat androgen-dependent conditions by changing how certain lipid enzymes are produced.

research Cortexolone 17a-propionate: Preclinical profile of a new topical, skin selective, steroidal antiandrogen

April 2012 in “Journal of the American Academy of Dermatology”

Clofazimine may be effective for treating ashy dermatosis.

research Effective Extraction of Keratin from Human Hair under Mild Conditions Using DES Based on Choline Chloride and Ethanolamine

December 2023 in “ACS Sustainable Chemistry & Engineering”

Keratin can be successfully taken from human hair using a mix of choline chloride and ethanolamine.

research [Antiandrogen therapy of acne, falling hair and hirsutism (author's transl)].

June 1980 in “PubMed”

Cyproterone acetate is an effective treatment for women with acne, hair loss, and excessive hair growth.

research 1103 Derinat extends hair cycle at anagen phase by decreasing the level of TRPCs-mediated intracellular ROS accumulation in skin

April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

Derinat helps extend hair growth by reducing harmful molecules in skin cells.

research The use of liposomes in the topical application of steroids

33 citations , May 1984 in “Journal of Pharmacy and Pharmacology”

Liposomes are not better than acetone for applying DHT on skin.

research Steroid 5α-reductases and 3α-hydroxysteroid dehydrogenases: key enzymes in androgen metabolism

115 citations , March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

research Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13 -Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

16 citations , June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology”

The enzyme DHHC13 is essential for healthy hair and skin, and its deficiency leads to hair loss and skin problems.

research Formulation and Development of Adapalene Topical Nanohydrogel Using Different Surfactants and Cosurfactants for Antiacne Activity: In Vitro and Ex Vivo Evaluation

19 citations , January 2022 in “Journal of Nanomaterials”

NH-Tween-80 is a promising stable gel for treating acne.

research Reversible Alopecia with Localized Scalp Necrosis After Accidental Embolization of the Parietal Artery with Hyaluronic Acid

26 citations , March 2017 in “Aesthetic plastic surgery”

Accidental injection of hyaluronic acid caused temporary hair loss and skin damage, but treatment restored hair and healed the skin.

research TRIAMCINOLONE ACETONIDE INTRAMUSCULARLY: EFFECTIVE LONG‐ACTING STEROID THERAPY IN DERMATOLOGIC DISORDERS

10 citations , April 1964 in “Journal of the American Geriatrics Society”

Triamcinolone acetonide injections effectively treat skin disorders like eczema and psoriasis.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Re-Densification Effect of Pressure-Injected Peptide-Hyaluronic Acid Combination on Male Androgenic Alopecia

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