5 citations
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June 2008 in “Acta Cirurgica Brasileira” Finasteride causes sperm production decrease in Mesocricetus auratus.
2 citations
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December 2017 in “Theriogenology” Testosterone increases acidification in the vas deferens by up-regulating V-ATPase.
January 2018 in “Elsevier eBooks” 5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.
Finasteride impairs sperm quality and fertility in rats, even after stopping treatment.
104 citations
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October 1999 in “The Journal of Urology” Finasteride doesn't harm male fertility or sperm quality, but may slightly reduce ejaculate volume.
September 2008 in “Fertility and Sterility” Men and women in infertile couples feel using donor sperm may cause more stress and marital issues than using donor eggs.
10 citations
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September 2015 in “Folia Histochemica Et Cytobiologica” Finasteride treatment in male rats can reduce fertility and affect sperm development in their offspring.
4 citations
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September 1977 in “Lipids” Gerbils on a fat-deficient diet had altered fatty acid levels, hair loss, reduced sperm, and lower body weight.
August 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.
April 2026 in “The Journal of Urology” Finasteride and dutasteride reduce semen quality, with dutasteride having a stronger negative effect.
3 citations
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January 1993 in “Toxicological Sciences” 2-Ethylhexanoic acid harms fertility and delays development in rats.
48 citations
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February 2006 in “Molecular and Cellular Endocrinology” 5α-reductase inhibitors may reduce male fertility and could be used for male contraception.
December 2025 in “Microscopy and Microanalysis” Lycopene protects against testicular damage caused by finasteride.
53 citations
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January 2006 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” Reduced AR gene methylation may cause early pubic hair growth in girls.
27 citations
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April 1992 in “Biochemical Journal” Minoxidil reduces lysine hydroxylase in skin cells.
34 citations
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January 2004 in “Revista do Hospital das Clínicas” Finasteride may worsen infertility in men with existing issues, but stopping it can improve sperm health.
23 citations
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January 2007 in “Archives of Andrology” Finasteride may negatively affect male fertility.
2 citations
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March 2021 in “Reproduction” Finasteride may affect male fertility by interfering with specific sperm signaling.
October 1988 in “Pediatric research” Certain maturity signs appear before and after the first release of sperm in boys.
1 citations
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September 2023 in “Journal of Education Health and Sport” Anabolic-androgenic steroids are dangerous and educating people about their risks is essential.
January 2018 in “日本薬理学会年会要旨集 =” Stopping finasteride improves sperm quality but not semen volume in young men.
August 2024 in “The Journal of Urology” The 2024 guideline updates recommendations for genetic testing, imaging, and sperm retrieval in male infertility.
May 2023 in “Frontiers in Veterinary Science” Advancements in reproductive technologies for carnivores help conserve species and offer insights into human reproductive issues.
April 2024 in “JCEM case reports” A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.
11 citations
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March 2010 in “International Journal of Andrology” Finasteride 1-mg doesn't harm sperm or pregnancy chances.
2 citations
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September 2009 in “Hormone Molecular Biology and Clinical Investigation” Low dose finasteride decreases certain steroids, possibly increasing depression risk.
31 citations
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September 2008 in “International Journal of Andrology” 5-alpha-reductase inhibitors may cause a low incidence of erectile dysfunction that decreases over time.
3 citations
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February 2018 in “Human Reproduction” A man with testotoxicosis was fertile despite low FSH levels, suggesting high testosterone may allow sperm production without FSH.
116 citations
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December 2013 in “The Journal of Pediatrics” Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.
10 citations
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February 2020 in “Endocrine” Finasteride safely treats hair loss without harming hormones or reproduction, but may slightly reduce sexual function.