Ameliorative Potential of Lycopene Against Finasteride-Induced Seminiferous Tubules Damage in Adult Rats: A Histological, Immunohistochemical, and Biochemical Study

December 2025 in “ Microscopy and Microanalysis ”

Amany Mohamed Shalaby, Hamad Alsaykhan, Sulaiman Mohammed Alnasser, Mohammed Alorini, Fatima A. Jaber, Mohamed Ali Alabiad, Mahmoud Ramadan Elkholy, M. Shehab

finasteride lycopene dihydrotestosterone testosterone androgenic alopecia superoxide dismutase malondialdehyde caspase 3 BCL2 Propecia

TLDR Lycopene protects against testicular damage caused by finasteride.

The study investigates the protective effects of lycopene against testicular damage induced by finasteride in adult rats. Finasteride, commonly used for treating prostatic hyperplasia and androgenic alopecia, negatively impacts spermatogenesis, leading to infertility. The study involved four groups of rats: control, lycopene, finasteride, and lycopene–finasteride, with treatments administered for 8 weeks. Finasteride significantly reduced dihydrotestosterone and testosterone levels, decreased superoxide dismutase, increased malondialdehyde, and altered mRNA expression of caspase 3 and BCL2, leading to reduced sperm parameters and histopathological changes in seminiferous tubules. However, rats treated with both lycopene and finasteride showed minimal changes, suggesting that lycopene offers significant protection against finasteride-induced testicular damage.

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Research cited in this study

17 / 17 results

Protective Role of Hesperidin in Finasteride-Induced Testicular Toxicity in Adult Male Wistar Rats: Insights Into Oxidative Stress, Apoptosis, and Ultrastructure of Seminiferous Tubules

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Hesperidin helps protect against testicular damage caused by finasteride.

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In Vivo and In Silico Evaluation of the Ameliorative Effect of Hesperidin on Finasteride-Induced Testicular Oxidative Stress in Wistar Rats

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