Wound healing involves three phases and various cells and factors, with scars typically forming in adults. Chronic wounds can occur due to various issues, and abnormal scarring can lead to hypertrophic or keloid scars. Emerging research areas include the role of proteins, microRNAs, macrophage manipulation, and stem cell treatment.
17 citations
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February 2025 in “Smart Medicine” The microneedle patch speeds up wound healing and prevents infection.
28 citations
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July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” Dermal papilla cells are crucial for hair growth and can induce new hair follicles.
February 2024 in “Research Square (Research Square)” Tiny particles from skin cells can help grow new hair by activating a specific growth signal during skin healing.
26 citations
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January 1994 in “Clinics in Dermatology” Artificial skin is improving wound healing and shows potential for treating different types of wounds.
6 citations
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February 2023 in “Biomaterials Research” Special gels help heal diabetic foot sores and reduce the risk of amputation or death.
February 2024 in “Bioengineering” The hydrogel made of chitosan, HPMC, and insulin speeds up wound healing and could be a new dressing, especially for diabetics.
April 2017 in “Journal of Investigative Dermatology” Scientists created a tiny, 3D model of a hair follicle that grows and acts like a real one.
12 citations
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May 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” Laminin 332 is essential for normal skin cell behavior and structure.
February 2019 in “Chin J Injury Repair and Wound Healing(Electronic Edition)” Porcine acellular dermal matrix helps hair growth by boosting specific proteins and signals.
2 citations
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February 2024 in “International Journal of Molecular Sciences” Negative Pressure Wound Therapy speeds up wound healing by reducing inflammation and promoting skin cell growth.
2 citations
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August 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” The Aligned membranes improved wound healing and hair growth with a better immune response in mice.
January 1997 in “Han-guk hyeonmigyeong hakoeji/Applied microscopy” The hair follicle's connection to connective tissue is weaker than the skin's.
October 2025 in “Clinical Cosmetic and Investigational Dermatology” Targeting specific cell interactions may help treat skin fibrosis.
508 citations
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February 2007 in “Cell” Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.
7 citations
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February 1982 in “Australian Journal of Biological Sciences” Epithelial cells from young rat hair follicles grow and form aggregates in culture, but don't produce hair keratin proteins.
September 2022 in “Institutional Repositories DataBase (IRDB)” Epidermal stem cells help renew skin and heal wounds, influenced by specific proteins and markers.
3 citations
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September 2024 3DEEP reveals early hair follicle stem cell formation and niche establishment before hair bulb development.
10 citations
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September 2018 in “Regenerative Medicine” New hair can grow from large wounds in mice, but less so as they age, involving reprogramming of skin cells and specific molecular pathways.
5 citations
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August 2011 in “Biotechnology and Bioprocess Engineering”
6 citations
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June 2022 in “Frontiers in Bioengineering and Biotechnology” The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.
59 citations
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August 2024 in “Cell stem cell” 23 citations
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June 2015 in “Experimental Dermatology” Pericytes can both help and hinder wound healing, needing more research for effective use in treatments.
April 2017 in “Plastic and reconstructive surgery. Global open” Fetal scalp cells have more regenerative genes than adult cells, and decellularized muscle matrix is better for muscle repair than commercial alternatives.
30 citations
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February 2022 in “Pharmaceutics” 3D bioprinting improves wound healing by precisely creating scaffolds with living cells and biomaterials, but faces challenges like resolution and speed.
84 citations
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January 2018 in “Biomaterials Science” Sericin hydrogels heal skin wounds well, regrowing hair and glands with less scarring.
22 citations
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April 2017 in “Cell Stem Cell” Skin wounds can create fat cells that help regenerate hair follicles, with BMP signaling playing a crucial role in this process.
3 citations
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December 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Disrupting YAP signaling in skin cells leads to scar-free healing directed by specific cell signals.
17 citations
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April 2022 in “Bioactive Materials” Continuous microfluidic processes can help scale up microtissue production for industrial and clinical use.