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GlossaryDepression

persistent sadness and loss of interest affecting daily life

Depression, also known as Major Depressive Disorder (MDD), is a mental health condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in activities. It can also involve physical symptoms such as changes in sleep, appetite, and energy levels, and can significantly impair daily functioning.

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Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α‐Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

research Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects

134 citations , August 2012 in “The Journal of Clinical Psychiatry”

Former finasteride users with persistent sexual side effects have higher rates of depression and suicidal thoughts.

research Finasteride induced depression: a prospective study

99 citations , October 2006 in “BMC clinical pharmacology”

Finasteride may cause slight depression and anxiety.

research Association of Suicidality and Depression With 5α-Reductase Inhibitors

90 citations , March 2017 in “JAMA Internal Medicine”

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

Depression Related to Finasteride Administration for Androgenetic Alopecia

research Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia

88 citations , October 2002 in “Journal of Dermatology”

Finasteride for hair loss may cause depression, affecting sleep and relationships.

research Depression, anxiety and perceived stress in women with and without PCOS: a community-based study

85 citations , August 2018 in “Psychological Medicine”

Women with PCOS are more likely to suffer from depression, anxiety, and stress.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

research Neuroactive Steroid Levels are Modified in Cerebrospinal Fluid and Plasma of Post‐Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

73 citations , July 2013 in “The Journal of Sexual Medicine”

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

research A mixed methods survey of social anxiety, anxiety, depression and wig use in alopecia

69 citations , April 2017 in “BMJ open”

Many people with alopecia experience high levels of social anxiety, anxiety, and depression, and while wigs can boost confidence, they may also cause anxiety.

research Hair loss perception and symptoms of depression in female outpatients attending a general dermatology clinic

49 citations , June 2012 in “Anais Brasileiros de Dermatologia”

Hair loss in women is linked to higher depression symptoms.

research Putative role for insulin resistance in depression risk in polycystic ovary syndrome

46 citations , June 2015 in “Fertility and Sterility”

Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.

research Evaluation of affective temperament and anxiety–depression levels of patients with polycystic ovary syndrome

35 citations , July 2015 in “Journal of Affective Disorders”

Women with PCOS tend to have higher anxiety and depression levels compared to healthy women.

research Finasteride-induced depression: new insights into possible pathomechanisms

22 citations , December 2010 in “Journal of Cosmetic Dermatology”

Finasteride may increase depression by reducing brain cell growth.

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, Lower Self-Esteem, and Lower Quality of Life

research Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

16 citations , January 2019 in “Neuropsychobiology”

People with Lichen Planopilaris tend to be more depressed, have lower self-esteem, and a worse quality of life.

research Prevalence of depression and anxiety in women with polycystic ovary syndrome (PCOS) and associated factors in a quaternary hospital in Thailand: a cross-sectional study

13 citations , November 2024 in “BMC Psychiatry”

Women with PCOS often have depression and anxiety, so they should be checked for these issues.

research Association between severity of depression and clinico-biochemical markers of polycystic ovary syndrome

11 citations , November 2017 in “Electronic physician”

Depression severity is not linked to PCOS markers like BMI, insulin resistance, or testosterone levels.

research Persistent sexual dysfunction and depression in finasteride users for male pattern hair loss: a serious concern or red herring?

10 citations , December 2014 in “PubMed”

Finasteride, a hair loss drug, may cause sexual dysfunction and depression, but these effects are usually temporary and the drug is generally safe. More research is needed.

research Risk of Depression Associated With Finasteride Treatment

7 citations , April 2021 in “Journal of Clinical Psychopharmacology”

Finasteride may increase the risk of depression, anxiety, and suicidal thoughts.

research Depression and anxiety in women with polycystic ovarian syndrome: a literature survey

7 citations , August 2021 in “International journal of adolescent medicine and health”

Women with polycystic ovarian syndrome often experience depression and anxiety.

research Comparing quality of life, anxiety, depression, sleep disturbance, and associated factors in vitiligo and alopecia areata patients

6 citations , January 2024 in “Journal of Cosmetic Dermatology”

Alopecia areata patients have worse quality of life, anxiety, and depression than vitiligo patients.

research Serum brain‐derived neurotrophic factor and vitamin D: Two concordant players controlling depression among alopecia areata and vitiligo patients: A case–control study

6 citations , March 2023 in “Journal of Cosmetic Dermatology”

Low levels of BDNF and vitamin D are linked to higher depression in alopecia areata and vitiligo patients.

research Anxiety and Depression in Patients with Alopecia Areata in Eskisehir, Turkey

5 citations , September 2023 in “Clinical Cosmetic and Investigational Dermatology”

Patients with Alopecia Areata often have higher anxiety and depression.

research Quality of Life and the Presence of Depression Among Adults with Hair Loss in the South of Saudi Arabia

5 citations , August 2022 in “Psychology Research and Behavior Management”

Hair loss in South Saudi Arabia adults often harms quality of life and leads to depression.

Insulin Resistance, Hyperandrogenism, and Their Associated Symptoms as Precipitating Factors for Depression in Women With Polycystic Ovarian Syndrome

research Insulin Resistance, Hyperandrogenism, and Its Associated Symptoms Are the Precipitating Factors for Depression in Women With Polycystic Ovarian Syndrome

5 citations , September 2021 in “Cureus”

Depression in women with Polycystic Ovarian Syndrome (PCOS) is linked to insulin resistance and hyperandrogenism, and managing these can help reduce depression. Lifestyle changes and Cognitive Behavioral Therapy can be effective treatments.

research The Muscle Immobility of Depression—The Weightlessness Within

5 citations , January 2012 in “Psychology”

Depression may be linked to changes in body electrolytes and muscle inactivity, similar to effects of weightlessness.

research Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

4 citations , October 2023 in “Journal of clinical medicine”

Women with PCOS are much more likely to experience depression.

research Anxiety, depression, and quality of life in children and adults with alopecia areata: A systematic review and meta-analysis

4 citations , November 2022 in “Frontiers in Medicine”

People with alopecia areata are more likely to have anxiety and depression and a lower quality of life.