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GlossaryDepressive Symptoms

persistent feelings of sadness, hopelessness, and loss of interest

Depressive symptoms, also known as symptoms of depression, refer to a range of emotional, cognitive, and physical signs that indicate the presence of depression. These can include persistent feelings of sadness or hopelessness, loss of interest in activities once enjoyed, changes in appetite or weight, difficulty sleeping or oversleeping, fatigue, difficulty concentrating, and thoughts of death or suicide. Recognizing these symptoms is crucial for both laypersons and professionals to identify and address depression effectively.

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Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

research Neuroactive Steroid Levels are Modified in Cerebrospinal Fluid and Plasma of Post‐Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

73 citations , July 2013 in “The Journal of Sexual Medicine”

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Children And Adolescents With Alopecia Areata: Psychiatric Symptomatology And Life Events: A Longitudinal Case-Control Study: Before And During The COVID-19

research Children and Adolescents with Alopecia Areata: Psychiatric Symptomatology and Life Events: A longitudinal case-control study: Before and During the COVID-19

May 2026 in “Research Square”

Children with alopecia areata often face more stress and depression, especially related to separation, which can affect their condition.

Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

research Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma

61 citations , April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Response to Article 'Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia' (Journal of Dermatology, 29, 665-669, 2002)

research Response to Article “Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia” (J Dermatol, 29, 665-669, 2002)

November 2003 in “Journal of Dermatology”

Finasteride's link to depression is questionable due to study flaws and potential bias.

research Assessment of the Vitamin D Levels in the Patients Presenting with Different Medical Conditions and its Correlation with Symptomatology

3 citations , January 2009 in “Annals of King Edward Medical University”

Most urban, well-fed people in Pakistan have severe vitamin D deficiency and show symptoms.

research P.6.028 Transnosography of impulsiveness:A comparison among different psychiatric disorders

October 2004 in “European Neuropsychopharmacology”

Impulsiveness is common across various psychiatric disorders and linked to many psychological symptoms.

research Association of Suicidality and Depression With 5α-Reductase Inhibitors

90 citations , March 2017 in “JAMA Internal Medicine”

Men over 66 taking medication for prostate enlargement have a higher risk of depression and self-harm, especially in the first 18 months of treatment.

research The Dark Side of 5α-Reductase Inhibitors' Therapy: Sexual Dysfunction, High Gleason Grade Prostate Cancer and Depression

75 citations , January 2014 in “Korean Journal of Urology”

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

research Putative role for insulin resistance in depression risk in polycystic ovary syndrome

46 citations , June 2015 in “Fertility and Sterility”

Insulin resistance is significantly linked to a higher risk of depression in women with PCOS.

research Depression among Alopecia Areata Patients: Prevalence and associated factors in a Tunisian sample

October 2024 in “La Tunisie Médicale”

Over half of alopecia areata patients in Tunisia experience depression, highlighting the need for psychological support.

research Parenting Styles and Psychological Effects on Children with Alopecia Areata: Exploring Family Dynamics, Anxiety, and Depression

April 2024 in “Research Square”

Children with alopecia areata often experience more anxiety and depression, linked to neglectful family dynamics.

research Pathophysiological mechanisms implicated in postpartum depression

142 citations , January 2019 in “Frontiers in Neuroendocrinology”

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

Current Prospective in the Management of Depression Using Off-Label Drugs and Advanced Drugs

research CURRENT PROSPECTIVE IN THE MANAGEMENT OF DEPRESSION USING OFF LABELLED DRUGS AND ADVANCED DRUGS

June 2023 in “International journal of biology, pharmacy and allied sciences”

New medications are improving depression treatment, emphasizing accurate diagnosis and chronic care.

research The Relationship of Treatment Modality in Alopecia Areata with Life Quality, Anxiety, and Depression

January 2018 in “Turkiye Klinikleri Journal of Medical Sciences”

Alopecia areata treatment should consider life quality and mental health, not just clinical results.

research Association Between 5-Alpha Reductase Inhibitor Use and The Risk of Depression: A Meta-Analysis.

3 citations , August 2020 in “Urology Journal”

Using 5-alpha reductase inhibitors may increase the risk of mild depression.

research Anxiety, Depression, and Quality of Life in Women with Polycystic Ovarian Syndrome

60 citations , May 2018 in “Indian Journal of Psychological Medicine”

Women with PCOS often experience anxiety, depression, and a lower quality of life.

research Trichotillomania in a Male Patient With Depression: A Case Report

November 2024 in “Cureus”

Combining therapy, behavior techniques, and medication can help manage trichotillomania and depression.

Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition

research Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition

37 citations , September 2018 in “Psychoneuroendocrinology”

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

research Persistent Sexual and Nonsexual Adverse Effects of Finasteride in Younger Men

24 citations , December 2013 in “Sexual medicine reviews”

Finasteride can cause sexual problems and depression in young men.

research Polycystic Ovarian Syndrome Elevates the Distress of Sexual Pain in Iranian Women with Infertility

May 2024 in “Research Square (Research Square)”

PCOS increases sexual pain distress in infertile women.

research Post-Finasteride Syndrome: An Underestimated Phenomenon

May 2017 in “Urology and andrology”

Finasteride and dutasteride, used for prostate issues and hair loss, can cause side effects like sexual dysfunction and mental issues, which may continue even after stopping the medication, a condition called post-finasteride syndrome, for which there's currently no cure.

research Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

50 citations , September 2016 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

research The Post-finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption

8 citations , July 2018 in “Current Sexual Health Reports”

Finasteride can cause lasting sexual dysfunction, depression, and other side effects, needing more research for treatment.

research Temperament and character differences of patients with polycystic ovary syndrome

7 citations , February 2019 in “Journal of gynecology obstetrics and human reproduction”

People with polycystic ovary syndrome (PCOS) are more likely to have higher levels of depression and anxiety, but their personality traits are similar to those without PCOS.

research Finasteride and Suicide: A Postmarketing Case Series

6 citations , January 2020 in “Dermatology”

Finasteride may increase suicide risk; more research needed.

research Finasteride administration potentiates the disruption of prepulse inhibition induced by forced swim stress

6 citations , April 2015 in “Behavioural Brain Research”

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

The Impact of the 5α-Reductase Inhibitors on Male Sexual Function and Psychological Well-Being

research The Impact of the 5α-Reductase Inhibitors (5α-RIs) on Male Sexual Function and Psychological Well-Being

1 citations , August 2015 in “Current Sexual Health Reports”

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

The Interaction Between Finasteride and Corticosterone Levels: Implications for Depression and Anxiety-Like Behavior and Hippocampal Synaptic Plasticity in Male Rats

research The interaction between finasteride and corticosterone levels: implications for depression-, and anxiety-like behavior and hippocampal synaptic plasticity in male rats

May 2025 in “Psychopharmacology”

Chronic finasteride use in male rats doesn't strongly cause depression or anxiety due to adaptive stress hormone changes.

Multidimensional Assessment of Adverse Events of Finasteride: A Real-World Pharmacovigilance Analysis Based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024

research Multidimensional assessment of adverse events of finasteride：a real-world pharmacovigilance analysis based on FDA Adverse Event Reporting System (FAERS) from 2004 to April 2024

March 2025 in “PLoS ONE”

Finasteride can cause long-term side effects like sexual dysfunction and depression.

Depression, Higher Level of Tension Induction, and Impaired Coping Strategies in Response to Stress in Women with PCOS Correlate with Clinical and Laboratory Indices of Hyperandrogenism and Not with Central Obesity and Insulin Resistance

research Depression, higher level of tension induction, and impaired coping strategies in response to stress in women with PCOS correlate with clinical and laboratory indices of hyperandrogenism and not with central obesity and insulin resistance

August 2024 in “Archives of Women s Mental Health”

Women with PCOS have more depression and stress due to high androgen levels, not obesity or insulin resistance.