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GlossaryDermal Papilla Fibroblasts

specialized cells at hair follicle base aiding hair growth

Dermal Papilla Fibroblasts are specialized cells located at the base of hair follicles. They play a crucial role in hair growth and regeneration by interacting with other cells to regulate the hair cycle and provide essential signals for hair follicle development.

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research 613 Assessment of the induction and morphogenic potential of human hair matrix cells and dermal papilla fibroblasts ex vivo

1 citations , September 2019 in “Journal of Investigative Dermatology”

Human hair matrix cells and dermal papilla fibroblasts can form early hair follicle structures but don't produce hair shafts yet.

Generation of Human Hair Follicle Organoids In Vitro and Ex Vivo by Co-Culture of Primary Human Hair Matrix Keratinocytes and Dermal Papilla Fibroblasts

research 773 Generation of human hair follicle organoids in vitro and ex vivo by co-culture of primary human hair matrix keratinocytes and dermal papilla fibroblasts

June 2020 in “Journal of Investigative Dermatology”

Scientists successfully grew mini hair follicles using human skin cells, which could help treat baldness.

Hair Strengthening Evaluation of Anisotropic Osmolyte Solutions (Inositol + Arginine): Cross-Talk Between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a Micro Hair Follicle 3D Model

research Hair Strengthening Evaluation of Anisotropic Osmolite Solutions (Inositol + Arginine): Cross-Talk between Dermal Papilla Fibroblast and Keratinocytes of the Outer Root Sheath Using a µHair Follicle 3D Model

September 2018 in “Cosmetics”

Inositol and arginine solutions improve hair follicle health and turnover.

research Keratinocytes maintain compartmentalization between dermal papilla and fibroblasts in 3D heterotypic tri‐cultures

16 citations , August 2019 in “Cell Proliferation”

Keratinocytes help keep hair follicle cells and skin cells separate in 3D cultures, which is important for hair growth research.

research Human Scalp Dermal Papilla and Fibrous Sheath Cells have a different expression profile of Matrix Metalloproteinases in vitro when compared to Scalp Dermal Fibroblasts

9 citations , August 2005 in “Archives of Dermatological Research”

Scalp dermal papilla and fibrous sheath cells have different MMP expression than scalp dermal fibroblasts.

research Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells

66 citations , February 2007 in “The journal of investigative dermatology/Journal of investigative dermatology”

Adenosine may promote hair growth by increasing FGF-7 levels in dermal papilla cells.

research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

37 citations , June 2019 in “Stem cells”

Special particles from skin cells can promote hair growth by activating a specific growth signal.

research Chemically induced transformation of human dermal fibroblasts to hair‐inducing dermal papilla‐like cells

8 citations , July 2019 in “Cell Proliferation”

Researchers found a way to turn skin cells into cells that can grow new hair.

research Effect of Fibroblast Growth Factor 10 and an Interacting Non-Coding RNA on Secondary Hair Follicle Dermal Papilla Cells in Cashmere Goats’ Follicle Development Assessed by Whole-Transcriptome Sequencing Technology

2 citations , July 2023 in “Animals”

FGF10 and non-coding RNAs are important for cashmere goat hair follicle development.

research Dermal Hedgehog Signaling in Papillary Fibroblasts: An Emerging Key Player in Skin Regeneration

2 citations , January 2022 in “Journal of Investigative Dermatology”

Hedgehog signaling in skin cells is crucial for hair growth and skin healing, but needs to be balanced to avoid harmful effects like scarring and cancer.

research Primary cell culture and morphological characterization of canine dermal papilla cells and dermal fibroblasts

32 citations , February 2002 in “Veterinary Dermatology”

Canine dermal papilla cells and fibroblasts have distinct growth patterns and protein expressions.

research Expression Profiles of Tyrosine Kinases in Cultured Follicular Papilla Cells Versus Dermal Fibroblasts

11 citations , July 2004 in “Journal of Investigative Dermatology”

Certain tyrosine kinases may regulate hair growth and could help develop hair loss treatments.

Induction of Dermal Fibroblasts into Dermal Papilla Cell-Like Cells in Hydrogel Microcapsules for Enhanced Hair Follicle Regeneration

research Induction of dermal fibroblasts into dermal papilla cell-like cells in hydrogel microcapsules for enhanced hair follicle regeneration

4 citations , August 2020 in “Applied Materials Today”

Hydrogel microcapsules help create cells that boost hair growth.

research Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo

4 citations , December 2022 in “Cells”

Engineered nanovesicles from fibroblasts may help treat hair loss by promoting hair growth.

research Effect of Marine-Derived Saccharides on Human Skin Fibroblasts and Dermal Papilla Cells

2 citations , May 2023 in “Marine Drugs”

Marine-derived saccharides may help reduce aging effects on skin and hair by promoting cell growth and collagen production.

research Hair-follicle dermal papilla and sheath fibroblasts provide a supportive microenvironment for human skin regeneration

3 citations , May 2017 in “British journal of dermatology/British journal of dermatology, Supplement”

Certain cells around hair follicles help improve skin regeneration for potential use in skin grafts.

research Human hair follicle dermal papilla cell, dermal sheath cell and interstitial dermal fibroblast characteristics.

36 citations , September 1996 in “PubMed”

DP and DS cells are different from DF cells in structure and function.

Direct Reprogramming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules

research Direct Reprograming of Mouse Fibroblasts into Dermal Papilla Cells via Small Molecules

3 citations , April 2022 in “International Journal of Molecular Sciences”

Scientists turned mouse skin cells into hair-inducing cells using chemicals, which could help treat hair loss.

research Direct reprogramming of human fibroblasts into hair-inducing dermal papilla cell-like cells by a single small molecule

January 2025 in “Biochemical Pharmacology”

Peficitinib can turn human fibroblasts into cells that help grow hair.

Fibroblast Growth Factor 5-Short (FGF5s) Inhibits the Activity of FGF5 in Primary and Secondary Hair Follicle Dermal Papilla Cells of Cashmere Goats

research Fibroblast growth factor 5-short (FGF5s) inhibits the activity of FGF5 in primary and secondary hair follicle dermal papilla cells of cashmere goats

42 citations , September 2015 in “Gene”

FGF5s can block the effects of FGF5, which may help control hair growth in cashmere goats.

Adenosine Stimulates Growth of Dermal Papilla and Lengthens the Anagen Phase by Increasing the Cysteine Level via Fibroblast Growth Factors 2 and 7 in an Organ Culture of Mouse Vibrissae Hair Follicles

research Adenosine stimulates growth of dermal papilla and lengthens the anagen phase by increasing the cysteine level via fibroblast growth factors 2 and 7 in an organ culture of mouse vibrissae hair follicles

28 citations , October 2011 in “International Journal of Molecular Medicine”

Adenosine helps hair grow longer and stronger by boosting certain growth factors and signaling pathways.

research Strengthening the cellular function of dermal fibroblasts and dermal papilla cells using nanovesicles extracted from stem cells using blue light-based photobiomodulation technology

3 citations , January 2025 in “Biomaterials Science”

Blue light-enhanced nanovesicles from stem cells improve skin and hair cell function, offering a safer treatment for skin and hair disorders.

research Murine skin-derived multipotent papillary dermal fibroblast progenitors show germline potential in vitro

4 citations , February 2023 in “Stem Cell Research & Therapy”

Mouse skin cells can become sperm-like cells in the lab.

research Soluble factors from human hair papilla cells and dermal fibroblasts dramatically increase the clonal growth of outer root sheath cells

62 citations , June 1993 in “Archives of Dermatological Research”

research Direct Conversion of Human Fibroblasts into Hair-Inducing Dermal Papilla Cell-Like Cells by a Single Small Molecule

January 2024 in “SSRN Electronic Journal”

Proteomic Analysis of Cultured Dermal Papilla, Dermal Sheath, and Dermal Fibroblast Cells from Female Scalp Highlights Alterations in the Cell Populations with Increasing Age

research 1429 Proteomic analysis of cultured dermal papilla, dermal sheath and dermal fibroblast cells from female scalp highlights alterations in the cell populations with increasing age

April 2023 in “Journal of Investigative Dermatology”

Protein analysis shows aging changes in scalp cell types from women.

research Corrections to “Adenosine Stimulates Fibroblast Growth Factor-7 Gene Expression Via Adenosine A2b Receptor Signaling in Dermal Papilla Cells”

June 2007 in “Journal of Investigative Dermatology”

research Differentiation capacity of stromal fibroblast-like cells from human bone marrow, adipose tissue, hair follicle dermal papilla and derma

7 citations , February 2009 in “Cell and tissue biology”

research Bone morphogenetic proteins 4 and 2/7 induce osteogenic differentiation of mouse skin derived fibroblast and dermal papilla cells

28 citations , November 2013 in “Cell and Tissue Research”

research 564 Subpopulations of dermal fibroblasts produce distinct extracellular matrices

August 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Different types of skin cells create unique support structures that can affect skin cell growth and could help in skin repair.